Lung Tissue Research Consortium (LTRC)
The LTRC is a resource program of the NHLBI that provides human lung tissues to qualified investigators for use in their research. The program enrolls donor subjects who are anticipating lung surgery, collects blood and extensive phenotypic data from the prospective donors, and then processes their surgical waste tissues for research use. Most donor subjects have interstitial fibrotic lung disease or COPD. A standardized protocol is followed to assure high quality and uniformity of the data and biospecimens, and tissue samples are processed to allow pathological study, immunohistochemistry, gene expression analyses, biomarker measurements, genetic analyses, and electron microscopy. Phenotypic data include clinical and pathological diagnoses, chest CT images, pulmonary function tests, exposure and symptom questionnaires, and exercise tests. The LTRC provides tissues and data to approved investigators free of charge, but the LTRC does not provide funding to support research.
The NHLBI Project Officer for the LTRC is
Tom Croxton, Ph.D., M.D.
LTRC Public Site
Clinical Centers
- The Mayo Clinic
- University of Colorado
- University of Michigan
- University of Pittsburgh
- Clinical Trials & Surveys Corp.
January 2004 to January 2009
NHLBI-HR-04-08: Clinical Centers
NHLBI-HR-04-11: Data Coordinating Center
NHLBI-HR-04-09: Tissue Core Laboratory
NHLBI-HR-04-10: Radiology Core Laboratory
|