National Institute on Aging
National Institutes of Health 		NIA Home
Research Programs
Intramural
Laboratory of Immunology
Publications

  1. Baatar D, Olkhanud P, Newton D, Sumitomo K, Biragyn A. CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors. J. Immunol. 179(3):1996-2004, 2007.

  2. Baatar D, Olkhanud P, Sumitomo K, Taub D, Gress R, Biragyn A. Human peripheral blood T regulatory cells (Tregs), functionally primed CCR4+ Tregs and unprimed CCR4- Tregs, regulate effector T cells using FasL. J. Immunol. 178(8):4891-4900, 2007.

  3. Berner, V., Liu, H., Zhou, Q., Alderson, K.L., Sun, K., Weiss, J.M., Back, T.C., Longo, D.L., Blazar, B.R., Wiltrout, R.H., Welniak, L.A., Redelman, D., Murphy, W.J.: IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. Nat. Med. 13(3):354-360, 2007.

  4. Biragyn A, Schiavo R, Olkhanud P, Sumitomo K, King A, McCain M, Indig FE, Almanzar G, Baatar D. Tumor-associated embryonic antigen-expressing vaccines that target CCR6 elicit potent CD8+ T cell-mediated protective and therapeutic antitumor immunity. J. Immunol. 179(2):1381-1388, 2007.

  5. Brodsky, M., Yosef, S., Galit, R., Albeck, M., Longo, D.L., Albeck, A., Sredni, B.: The synthetic tellurium compound, AS101, is a novel inhibitor of IL-1beta converting enzyme. J. Interferon Cytokine Res. 27(6):453-462, 2007.

  6. Chen, G., Ghosh, P., Osawa, H., Sasaki, C.Y., Rezanka, L., Yang, J., O'Farrell, T.J., Longo, D.L.: Resistance to TGF-beta 1 correlates with aberrant expression of TGF-beta receptor II in human B-cell lymphoma cell lines. Blood. 109(12):5301-5307, 2007.

  7. Cui, W., Taub, D.D., Gardner, K.: qPrimerDepot: a primer database for quantitative real time PCR. Nucleic Acids Res. 35(Database issue):D805-D809, 2007.

  8. Dissanayake, S.K., Wade, M., Johnson, C.E., O'Connell, M.P., Leotlela, P.D., French, A.D., Shah, K.V., Hewitt, K.J., Rosenthal, D.T., Indig, F.E., Jiang, Y., Nickoloff, B.J., Taub, D.D., Trent, J.M., Moon, R.T., Bittner, M., Weeraratna, A.T.: The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J. Biol. Chem. 282(23):17259-17271, 2007.

  9. Ferrucci, L., Guralnik, J.M., Bandinelli, S., Semba, R.D., Lauretani, F., Corsi, A., Ruggiero, C., Ershler, W.B., Longo, D.L.: Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers. Br. J. Haematol. 136(6):849-855, 2007.

  10. Galban, C.J., Ling, S.M., Galban, C.J., Taub, D.D., Gurkan, I., Fishbein, K.W., Spencer, R.G.: Effects of knee injection on skeletal muscle metabolism and contractile force in rats. Osteoarthritis Cartilage. 15(5):550-558, 2007.

  11. Giri, B., Dixit, V.D., Ghosh, M.C., Collins, G.D., Khan, I.U., Madara, K., Weeraratna, A.T., Taub, D.D.: CXCL12-induced partitioning of flotillin-1 with lipid rafts plays a role in CXCR4 function. Eur. J. Immunol. 37(8):2104-2116, 2007.

  12. Godlove, J., Chiu, W.K., Weng, N.P.: Gene expression and generation of CD28-CD8 T cells mediated by interleukin 15. Exp. Gerontol. 42(5): 412-415, 2007.

  13. Hayun, M., Okun, E., Hayun, R., Gafter, U., Albeck, M., Longo, D.L., Sredni, B.: Synergistic effect of AS101 and Bryostatin-1 on myeloid leukemia cell differentiation in vitro and in an animal model. Leukemia. 21(7):1504-1513, 2007.

  14. Leotlela, P.D., Wade, M.S., Duray, P.H., Rhode, M.J., Brown, H.F., Rosenthal, D.T., Dissanayake, S.K., Earley, R., Indig, F.E., Nickoloff, B.J., Taub, D.D., Kallioniemi, O.P., Meltzer, P., Morin, P.J., Weeraratna, A.T.: Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility. Oncogene. 26(26):3846-3856, 2007.

  15. Lustig, A., Weeraratna, A.T., Wood, W.W. 3rd, Teichberg, D., Bertak, D., Carter, A., Poosala, S., Firman, J., Becker, K.G., Zonderman, A.B., Longo, D.L., Taub, D.D.: Transcriptome analysis of age-, gender- and diet-associated changes in murine thymus. Cell Immunol. 245(1):42-61, 2007.

  16. McKinstry, K.K., Golech, S., Lee, W.H., Huston, G., Weng, N.P., Swain, S.L.: (Rapid default transition of CD4 T cell effectors to functional memory cells. J. Exp. Med. [Epub ahead of print]. 2007.

  17. Sredni, B., Geffen-Aricha, R., Duan, W., Albeck, M., Shalit, F., Lander, H.M., Kinor, N., Sagi, O., Albeck, A., Yosef, S., Brodsky, M., Sredni-Kenigsbuch, D., Sonino, T., Longo, D.L., Mattson, M.P., Yadid, G.: Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson's disease models. FASEB J. 21(8):1870-1883, 2007.

  18. Stote, K.S., Baer, D.J., Spears, K., Paul, D.R., Harris, G.K., Rumpler, W.V., Strycula, P., Najjar, S.S., Ferrucci, L., Ingram, D.K., Longo, D.L., Mattson, M.P.: A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am. J. Clin. Nutr. 85(4):981-988, 2007.

  19. Weeraratna, A.T., Kalehua, A., Deleon, I., Bertak, D., Maher, G., Wade, M.S., Lustig, A., Becker, K.G., Wood, W. 3rd, Walker, D.G., Beach, T.G., Taub, D.D.: Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues. Exp. Cell Res. 313(3):450-461, 2007.

  20. Weeraratna, A.T., Taub, D.D.: Microarray data analysis: an overview of design, methodology, and analysis. Methods Mol. Biol. 377:1-16, 2007.

  21. Zou, S., Sinclair, J., Wilson, M.A., Carey, J.R., Liedo, P., Oropeza, A., Kalra, A., de Cabo, R., Ingram, D.K., Longo, D.L., Wolkow, C.A.: Comparative approaches to facilitate the discovery of prolongevity interventions: Effects of tocopherols on lifespan of three invertebrate species. Mech. Ageing Dev. 128(2):222-226, 2007.

  22. Cha SC, Kwak LW, Ruffini PA, Qin H, Neelapu S, Biragyn A. Cloning of B cell lymphoma-associated antigens using modified phage-displayed expression cDNA library and immunized patient sera. J. Immunol. Methods. 312(1-2):79-93, 2006.

  23. Chiu, W.K., Fann, M., Weng, N.P.: Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines. J. Immunol. 177(11):7802-7810, 2006.

  24. Dawson, H.D., Collins, G., Pyle, R., Key, M., Weeraratna, A., Deep-Dixit, V., Nadal, C.N., Taub, D.D.: Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes. BMC Immunol. 7:27, 2006.

  25. Dixit, V.D., Weeraratna, A.T., Yang, H., Bertak, D., Cooper-Jenkins, A., Riggins, G.J., Eberhart, C.G., Taub, D.D.: Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility. J. Biol. Chem. 281(24):16681-16690, 2006.

  26. Ershler, W.B., Longo, D.L.: A report card for geriatric oncology: borderline pass, improvement needed. J. Gerontol. A Biol. Sci. Med. Sci. 61(7):688, 2006.

  27. Fann, M., Godlove, J.M., Catalfamo, M., Wood, W.H. 3rd, Chrest, F.J., Chun, N., Granger, L., Wersto, R., Madara, K., Becker, K., Henkart, P.A., Weng, N.P.: Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8(+) T-cell response. Blood. 108(10):3363-3370, 2006.

  28. Feng, Y., Yuan, J.H., Maloid, S.C., Fisher, R., Copeland, T.D., Longo, D.L., Conrads, T.P., Veenstra, T.D., Ferris, A., Hughes, S., Dimitrov, D.S., Ferris, D.K.: Pole-like kinase 1-mediated phosphorylation of the GTP-binding protein Ran is important for bipolar spindle formation. Biochem. Biophys. Res. Commun. 349(1):144-152, 2006.

  29. Ferrucci, L., Maggio, M., Bandinelli, S., Basaria, S., Lauretani, F., Ble, A., Valenti, G., Ershler, W.B., Guralnik, J.M., Longo, D.L.: Low testosterone levels and the risk of anemia in older men and women. Arch. Intern. Med. 166(13):1380-1388, 2006.

  30. Lee, G.D., Longo, D.L., Wang, Y., Rifkind, J.M., Abdul-Raman, L., Mamczarz, J.A., Duffy, K.B., Spangler, E.L., Taub, D.D., Mattson, M.P., Ingram, D.K.: Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clin. Cancer Res. 12(1):198-205, 2006.

  31. Longo, D.L.: Idiotype vaccination in follicular lymphoma: knocking on the doorway to cure. J. Natl. Cancer. Inst. 98(18):1263-1265, 2006.

  32. Maggio, M., Guralnik, J.M., Longo, D.L., Ferrucci, L.: Interleukin-6 in aging and chronic disease: a magnificent pathway. J. Gerontol. A Biol. Sci. Med. Sci. 61(6):575-584, 2006.

  33. McHutchison, J.G., Manns, M.P., Longo, D.L.: Definition and management of anemia in patients infected with hepatitis C virus. 26(4):389-398, 2006.

  34. Palaniappan, R., Singh, S., Singh, U.P., Singh, R., Ades, E.W., Briles, D.E., Hollingshead, S.K., Royal, W. 3rd, Sampson, J.S., Stiles, J.K., Taub, D.D., Lillard, J.W. Jr.: CCL5 modulates pneumococcal immunity and carriage. J. Immunol. 176(4):2346-2356, 2006.

  35. Schiavo, R., Baatar, D., Olkhanud, P., Indig, F.E., Restifo, N., Taub, D., Biragyn, A.: Chemokine receptor targeting efficiently directs antigens to MHC class I pathways and elicits antigen-specific CD8+ T cell responses. Blood. 107(12):4597-4605. 2006.

  36. Swain, S.L., Agrewala, J.N., Brown, D.M., Jelley-Gibbs, D.M., Golech, S., Huston, G., Jones, S.C., Kamperschroer, C., Lee, W.H., McKinstry, K.K., Roman, E., Strutt, T., Weng, N.P.: CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza. Immunol. Rev. 211:8-22, 2006.

  37. Weng, N.P.: Aging of the immune system: how much can the adaptive immune system adapt? Immunity. 24(5):495-499, 2006.

  38. Biragyn, A.: Defensins - Non-antibiotic use for vaccine development. Curr. Protein Pept. Sci. 6(1):53-60, 2005.

  39. Ble, A., Windham, B.G., Bandinelli, S., Taub, D.D., Volpato, S., Bartali, B., Tracy, R.P., Guralnik, J.M., Ferrucci, L.: Relation of plasma leptin to C-reactive protein in older adults (from the Invecchiare nel Chianti Study). Am. J. Cardiol. 96(7):991-995, 2005.

  40. Chabner, BA, Longo, DL. (Eds.), Cancer Chemotherapy and Biotherapy: Principles and Practice, 4th edition. Philadelphia: Lippincott Williams and Wilkins, 2005, pp. 1000.

  41. Dixit, V.D., Taub, D.D.: Ghrelin and immunity: A young player in an old field. Exp. Gerontol. 40(11):900-910, 2005.

  42. Ershler, W.B., Sheng, S., McKelvey, J., Artz, A.S., Denduluri, N., Tecson, J., Taub, D.D., Brant, L.J., Ferrucci, L., Longo, D.L.: Serum erythropoietin and aging: a longitudinal analysis. J Am Geriatr Soc. 53(8):1360-1365, 2005.

  43. Fann, M., Chiu, W.K., Wood, W.H. 3rd, Levine, B.L., Becker, K.G., Weng, N.P.: Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging. Immunol. Rev. 205:190-206, 2005.

  44. Ferrucci, L., Corsi, A., Lauretani, F., Bandinelli, S., Bartali, B., Taub, D.D., Guralnik, J.M., Longo, D.L.: The origins of age-related pro-inflammatory state. Blood. 105(6):2294-2299, 2005.

  45. Ferrucci, L., Guralnik, J.M., Woodman, R.C., Bandinelli, S., Lauretani, F., Corsi, A.M., Chaves, P.H., Ershler, W.B., Longo, D.L.: Proinflammatory state and circulating erythropoietin in persons with and without anemia. Am. J. Med. 118(11):1288, 2005.

  46. Freebern, W.J., Haggerty, C.M., Montano, I., McNutt, M.C., Collins, I., Graham, A., Chandramouli, G.V., Stewart, D.H., Biebuyck, H.A., Taub, D.D., Gardner, K.: Pharmacologic profiling of transcriptional targets deciphers promoter logic. Pharmacogenomics J. 5(5):305-323, 2005.

  47. Gulmann, C., Espina, V., Petricoin, E. 3rd, Longo, D.L., Santi, M., Knutsen, T., Raffeld, M., Jaffe, E.S., Liotta, L.A., Feldman, A.L.: Proteomic analysis of apoptotic pathways reveals prognostic factors in follicular lymphoma. Clin. Cancer Res. 11(16):5847-5855, 2005.

  48. Kusaba, H., Ghosh, P., Derin, R., Buchholz, M., Sasaki, C., Madara, K., Longo, D.L.: Interleukin-12-induced IFN-g production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR). J. Biol. Chem. 280(2):1037-1043, 2005.

  49. Li, Y., Zhi, W., Wareski, P., Weng, N.P.: IL-15 activates telomerase and minimizes telomere loss and may preserve the replicative life span of memory CD8+ T cells in vitro. J. Immunol. 174(7):4019-4024, 2005.

  50. Longo, D.L.: Adjuvant therapy for localized breast cancer: radiation therapy improves disease control in women over age 50 years, but not in women over age 70 years. Postgrad. Med. 117(6):8, 2005.

  51. Longo, D.L.: Chimera: from bane to blessing. Blood. 106:1890-1891, 2005.

  52. Longo, D.L.: Closing in on a killer: anemia in elderly people. J. Gerontol. A Biol. Sci. Med. Sci. 60(6):727-728, 2005.

  53. Longo, D.L.: Radiation therapy in Hodgkin disease: why risk a Pyrrhic victory? J. Natl. Cancer Inst. 97(19):1394-1395, 2005.

  54. Longo, D.L.: Radiation therapy may improve survival of premenopausal women with breast cancer involving axillary lymph nodes. Postgrad. Med. 117(4):6, 2005.

  55. Nguyen, D.H., Giri, B., Collins, G., Taub, D.D.: Dynamic reorganization of chemokine receptors, cholesterol, lipid rafts, and adhesion molecules to sites of CD4 engagement. Exp Cell Res. 304(2):559-569, 2005.

  56. Rezanka, L.J., Kenny, J.J., Longo, D.L.: 2 BCR or NOT 2 BCR - receptor dilution: a unique mechanism for preventing the development of holes in the protective B cell repertoire. Immunobiology. 210(10):769-774, 2005.

  57. Rezanka, L.J., Kenny, J.J., Longo, D.L.: Dual isotype expressing B cells [k(+)/l(+)] arise during the ontogeny of B cells in the bone marrow of normal nontransgenic mice. Cell Immunol. 238(1):38-48, 2005.

  58. Sakatani, T., Kaneda, A., Iacobuzio-Donahue, C.A., Carter, M.G., Witzel, S.D., Okano, H., Ko, M.S., Ohlsson, R., Longo, D.L., Feinberg, A.P.: Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science. 307(5717):1976-1978, 2005.

  59. Sasaki, C.Y., Barberi, T.J., Ghosh, P., Longo, D.L.: Phosphorylation of RelA/p65 on serine 536 defines an Ik Ba -independent NF-k B pathway. J. Biol. Chem. 280(41):34538-34547, 2005.

  60. Taub, D.D., Longo, D.L.: Insights into thymic aging and regeneration. Immunol. Rev. 205:72-93, 2005.

  61. Dawson, H., Collins, G., Pyle, R., Deep-Dixit, V., Taub, D.D. The immunoregulatory effects of homocysteine and its intermediates on T-lymphocyte function. Mech. Ageing Dev. 125(2):107-110, 2004.

  62. de Mello Coelho, V., Nguyen, D., Giri, B., Bunbury, A., Schaffer, E., Taub, D.D. Quantitative differences in lipid raft components between murine CD4+ and CD8+ T cells. BMC Immunol. 5(1):2, 2004.

  63. Dixit, V.D., Schaffer, E.M., Pyle, R.S., Collins, G.D., Sakthivel, S.K., Palaniappan, R., Lillard, J.W. Jr., Taub, D.D.: Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J. Clin. Invest. 114(1):57-66, 2004.

  64. Ferrucci, L., Corsi, A., Lauretani, F., Bandinelli, S., Bartali, B., Taub, D.D., Guralnik, J.M., Longo, D.L.: The origins of age-related pro-inflammatory state. Blood. [Epub ahead of print], 2004.

  65. Hess, K., Yang, Y., Golech, S., Sharov, A., Becker, K.G., Weng, N.P.: Kinetic assessment of general gene expression changes during human naive CD4+ T cell activation. Int. Immunol. 16(12):1711-1721, 2004.

  66. Hu, L., Dixit, V.D., de Mello-Coelho, V., Taub, D.D.: Age-associated alterations in CXCL1 chemokine expression by murine B cells. BMC Immunol. 25(1): 15, 2004.

  67. Kalehua, A.N., Nagel, J.E., Whelchel, L.M., Gides, J.J., Pyle, R.S., Smith, R.J., Kusiak, J.W., Taub, D.D.: Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration. Exp. Cell Res. 297(1): 197-211, 2004.

  68. Lin, H.J., Wang, X., Shaffer, K.M., Sasaki, C.Y., Ma, W.: Characterization of H2O2-induced acute apoptosis in cultured neural stem/progenitor cells. FEBS Lett. 570(1-3): 102-106, 2004.

  69. Mattson, M.P., Taub, D.D.: Ancient viral protein enrages astrocytes in multiple sclerosis. Nat. Neurosci. 7(10): 1021-1023, 2004.

  70. Nagel, J.E., Smith, R.J., Shaw, L., Bertak, D., Dixit, V.D., Schaffer, E.M., Taub, D.D.: Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10. BMC Immunol. 5(1): 17, 2004.

  71. Nguyen, D.H., Espinoza, J.C., Taub, D.D.: Cellular cholesterol enrichment impairs T cell activation and chemotaxis. Mech. Ageing Dev. 125(9): 641-650, 2004.

  72. Nguyen, D.H., Taub, D.D.: Targeting lipids to prevent HIV infection. Mol. Interv. 4(6): 318-320, 2004.

  73. O'Farrell, T.J., Ghosh, P., Dobashi, N., Sasaki, C.Y., Longo, D.L.: Comparison of the effect of mutant and wild-type p53 on global gene expression. Cancer Res. 64(22): 8199-8207, 2004.

  74. Olsson, N., Taub, D.D., Nilsson, G.: Regulation of mast cell migration by T and T cytokines: identification of tumour necrosis factor-a and interleukin-4 as mast cell chemotaxins. Scand. J. Immunol. 59(3): 267-272, 2004.

  75. Rangel, L.B., Agarwal, R., Sherman-Baust, C.A., de Mello-Coelho, V., Pizer, E.S., Ji, H., Taub, D.D., Morin, P.J.: Anomalous expression of the HLA-DR a and b chains in ovarian and other cancer. Cancer Biol. Ther. 3(10), 2004.

  76. Ruffini, P.A., Biragyn, A., Coscia, M., Harvey, L.K., Cha, S.C., Bogen, B., Kwak, L.W.: Genetic fusions with viral chemokines target delivery of nonimmunogenic antigen to trigger antitumor immunity independent of chemotaxis. J. Leukoc. Biol. 76(1): 77-85, 2004.

  77. Singh, U.P., Singh, S., Ravichandran, P., Taub, D.D., Lillard, J.W. Jr.: Viral macrophage-inflammatory protein-II: a viral chemokine that differentially affects adaptive mucosal immunity compared with its mammalian counterparts. J. Immunol. 173(9): 5509-5516, 2004.

  78. Sredni, B., Weil, M., Khomenok, G., Lebenthal, I., Teitz, S., Mardor, Y., Ram, Z., Orenstein, A., Kershenovich, A., Michowiz, S., Cohen, Y.I., Rappaport, Z.H., Freidkin, I., Albeck, M., Longo, D.L., Kalechman, Y. Ammonium trichloro(dioxoethylene-o,o')tellurate (AS101) sensitizes tumors to chemotherapy by inhibiting the tumor interleukin 10 autocrine loop. Cancer Res. 64(5): 1843-1852, 2004.

  79. Takahashi, K., Reynolds, M., Ogawa, N., Longo, D.L., Burdick, J.: Augmentation of T-cell apoptosis by immunosuppressive agents. Clin. Transplant. 18 Suppl 12: 72-75, 2004.

  80. Taub, D.D., Mikovits, J.A., Nilsson, G., Schaffer, E.M., Key, M.L., Petrow-Sadowski, C., Ruscetti, F.W.: Alterations in mast cell function and survival following in vitro infection with human immunodeficiency viruses-1 through CXCR4. Cell Immunol. 230(2): 65-80. 2004.

  81. Weeraratna, A.T., Nagel, J.E., de Mello-Coelho, V., Taub, D.D. Gene expression profiling: from microarrays to medicine. J. Clin. Immunol. 24(3): 213-224, 2004.

  82. Westin, E.H., Longo, D.L.: Lymphoma and myeloma in older patients. Semin. Oncol. 31(2): 198-205, 2004.

  83. Yuan, J.H., Feng, Y., Fisher, R.H., Maloid, S., Longo, D.L., Ferris, D.K.: Polo-like kinase 1 inactivation following mitotic DNA damaging treatments is independent of ataxia telangiectasia mutated kinase. Mol. Cancer Res. 2(7): 417-426, 2004.

  84. Artz, A.S., Ershler, W.B., Longo, D.L. Pneumococcal vaccination and revaccination of older adults. Clin. Microbiol. Rev. 16(2): 308-318, 2003. [Abs]

  85. Dixit, V.D., Mielenz, M., Taub, D.D., Parvizi, N. Leptin induces growth hormone secretion from peripheral blood mononuclear cells via a protein kinase C- and nitric oxide-dependent mechanism. Endocrinology. 144(12): 5595-5603, 2003.
    86. [Abs]

  86. Ferrucci, L., Guralnik, J.M., Cavazzini, C., Bandinelli, S., Lauretani, F., Bartali, B., Repetto, L., Longo, D.L. The frailty syndrome: a critical issue in geriatric oncology. Crit. Rev. Oncol. Hematol. 46(2): 127-137, 2003.[Abs]

  87. Kalayjian, R.C., Landay, A., Pollard, R.B., Taub, D.D., Gross, B.H., Francis, I.R., Sevin, A., Pu, M., Spritzler, J., Chernoff, M., Namkung, A., Fox, L., Martinez, A., Waterman, K., Fiscus, S.A., Sha, B., Johnson, D., Slater, S., Rousseau, F., Lederman, M.M.; Adult AIDS Clinical Trial Group 5015 Protocol Team; Adult AIDS Clinical Trial Group 5113 Protocol Team. Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes. J. Infect. Dis. 187(12):1924-1933, 2003.
    88. [Abs]

  88. Lillard, J.W. Jr., Singh, U.P., Boyaka, P.N., Singh, S., Taub, D.D., McGhee, J.R. MIP-1alpha and MIP-1beta differentially mediate mucosal and systemic adaptive immunity. Blood. 101(3): 807-814, 2003.
    89. [Abs]

  89. Longo, D.L.: Immunology of aging. In: Paul, W.E. (Ed.) Fundamental Immunology, 5th edition, Philadelphia, Lippincott Williams, and Wilkins, 2003, pp. 1043-1075.

  90. Longo, D.L. Radiation therapy in the treatment of Hodgkin's disease--do you see what I see? J. Natl. Cancer Inst. 95(13): 928-929, 2003.
    91. [Journal]

  91. Nguyen, D.H., Taub, D.D. Inhibition of chemokine receptor function by membrane cholesterol oxidation. Exp. Cell Res. 291(1): 36-45, 2003.
    92. [Abs]

  92. Nguyen, D.H., Taub, D.D. Membrane incorporation of 22-hydroxycholesterol inhibits chemokine receptor activity. Exp. Cell Res. 285(2): 268-277, 2003.
    93. [Abs]

  93. Shack, S., Wang, X-T., Kokkonen, G.C., Gorospe, M., Longo, D.L., Holbrook, N.J. Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. Mol. Cell Biol. 23(7): 2407-2414, 2003.
    94. [Abs]

  94. Sharov, A.A., Piao, Y., Matoba, R., Dudekula, D.B., Qian, Y., VanBuren, V., Falco, G., Martin, P.R., Stagg, C.A., Bassey, U.C., Wang, Y., Carter, M.G., Hamatani, T., Aiba, K., Akutsu, H., Sharova, L., Tanaka, T.S., Kimber, W.L., Yoshikawa, T., Jaradat, S.A., Pantano, S., Nagaraja, R., Boheler, K.R., Taub, D., Hodes, R.J., Longo, D.L., Schlessinger, D., Keller, J., Klotz, E., Kelsoe, G., Umezawa, A., Vescovi, A.L., Rossant, J., Kunath, T., Hogan, B.L., Curci, A., D'Urso, M., Kelso, J., Hide, W., Ko, M.S.H. Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol. 1: 410-419, 2003.
    95. [Abs]

  95. Singh, U.P., Singh, S., Taub, D.D., Lillard, J.W. Jr. Inhibition of IFN-g-inducible protein-10 abrogates colitis in IL-10-/- mice. J. Immunol. 171(3): 1401-1406, 2003.
    96. [Abs]

  96. Son, N.H., Joyce, B., Hieatt, A., Chrest, F.J., Yanovski, J., Weng, N.P. Stable telomere length and telomerase expression from naive to memory B-lymphocyte differentiation. Mech. Ageing. Dev. 124(4): 427-432, 2003.
    97. [Abs]

  97. Yano, S., Ghosh, P., Kusaba, H., Buchholz, M., Longo D.L. Effect of promoter methylation on the regulation of IFN-g gene during in vitro differentiation of human peripheral blood T cells into a Th2 population. J. Immunol. 171(5): 2510-2516, 2003.
    98. [Abs]

  98. Espinoza-Delgado, E., and Longo, D.L.: Non-Hodgkin's lymphoma. In: Laughlin, M.J. and Lazarus, H.M. (Eds.): Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Totowa, N.J., Humana Press, 2002, pp 83-99.

  99. Ghosh, P., Buchholz, M.A., Yano, S., Taub, D., Longo, D.L. Effect of rapamycin on the cyclosporin A-resistant CD28-mediated costimulatory pathway. Blood. 9(12): 4517-4524, 2002.
    100. [Abs]

  100. Hodes, R.J., Hathcock, K.S., Weng, N.P. Telomeres in T and B cells. Nat. Rev. Immunol. 2(9): 699-706, 2002.
    101. [Abs]

  101. Hu, L., Rezanka, L.J., Mi. Q.S., Lustig, A., Taub, D.D., Longo, D.L., Kenny J.J. T15-idiotype-negative B cells dominate the phosphocholine binding cells in the preimmune repertoire of T15i knockin mice. J. Immunol. 168(3): 1273-1280, 2002.
    102. [Abs]

  102. Liu, K., Catalfamo, M., Li, Y., Henkart, P.A., Weng, N.P. IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells. Proc. Natl. Acad. Sci. USA. 99(9): 6192-6197, 2002.
    103. [Abs]

  103. Longo, D.L. DR's orders: human antibody kills tumors by direct signaling. Nat. Med. 8(8): 781-783, 2002.
    104. [Abs]

  104. Longo, D.L. Genetic abnormalities in lymphoid malignancies. In: Vogelstein, B., and Kinzler, K.W. (Eds.): The Genetic Basis of Human Cancer, 2nd edition, New York, McGraw-Hill, 2002, pp. 785-801.

  105. Luo, Y., Long, J.M., Lu, C., Chan, S.L., Spangler, E.L., Mascarucci, P., Raz, A., Longo, D.L., Mattson, M.P., Ingram, D.K., and Weng, N.P. A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. J. Neurochem. 80: 354-361, 2002.
    106. [Abs]

  106. Mascarucci, P., Taub, D., Saccani, S., Paloma, M.A., Dawson, H., Roth, G.S., Lane, M.A., Ingram, D.K. Cytokine responses in young and old rhesus monkeys: effect of caloric restriction. J. Interferon. Cytokine Res. 22(5): 565-571, 2002.
    107. [Abs]

  107. Mi., Q.S., Rezanka, L.J., Lustig, A., Zhou, L., Longo, D.L., Kenny, J.J. The M603 idiotype is lost in the response to phosphocholine in terminal deoxynucleotidyl transferase-deficient mice. Eur. J. Immunol. 32(4): 1139-1146, 2002.
    108. [Abs]

  108. Nguyen, D.H., Taub, D. Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5. Blood. 99(12): 4298-4306, 2002.
    109. [Abs]

  109. Nguyen, D.H., Taub, D. CXCR4 function requires membrane cholesterol: implications for HIV infection. J. Immunol. 168(8): 4121-4126, 2002.
    110. [Abs]

  110. Oliveira, S.H., Taub, D.D., Nagel, J., Smith, R., Hogaboam, C.M., Berlin, A., Lukacs, N.W. Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis. Blood. 100(13): 4291-4297, 2002.
    111. [Abs]

  111. Rosenwald, A., Wright, G., Chan, W.C., Connors, J.M., Campo, E., Fisher, R.I., Gascoyne, R.D., Muller-Hermelink, H.K., Smeland, E.B., Giltnane, J.M., Hurt, E.M., Zhao, H., Averett, L., Yang, L., Wilson, W.H., Jaffe, E.S., Simon, R., Klausner, R.D., Powell, J., Duffey, P.L., Longo, D.L., Greiner, T.C., Weisenburger, D.D., Sanger, W.G., Dave, B.J., Lynch, J.C., Vose, J., Armitage, J.O., Montserrat, E., Lopez-Guillermo, A., Grogan, T.M., Miller, T.P., LeBlanc, M., Ott, G., Kvaloy, S., Delabie, J., Holte, H., Krajci, P., Stokke, T., Staudt, L.M. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N. Engl. J. Med. 346(25): 1937-1947, 2002.
    112. [Abs]

  112. Raziuddin, A., Longo, D.L., Bennett, M., Winkler-Pickett, R., Ortaldo, J.R., Murphy, W.J. Increased bone marrow allograft rejection by depletion of donor NK cells expressing inhibitory Ly49 NK receptors for donor class I antigens. Blood 100: 3026-3033, 2002.
    113. [Abs]

  113. Szocinski, J.L., Khaled, A.R., Hixon, J., Halverson, D., Funakoshi, S., Fanslow, W.C., Boyd, A., Taub, D.D., Durum, S.K., Siegall, C.B., Longo, D.L., Murphy, W.J. Activation-induced cell death of aggressive histology lymphomas by CD40 stimulation: induction of bax. Blood. 100(1): 217-223, 2002.
    114. [Abs]

  114. Weng, N.P. Regulation of telomerase expression in human lymphocytes. Springer Semin. Immunopathol. 24(1): 23-33, 2002.
    115. [Abs]

  115. Weng, N.P., Liu, K., Catalfamo, M., Li, Y., Henkart, P.A. L-15 is a growth factor and an activator of CD8 memory T cells. Ann. NY Acad. Sci. 975: 46-56, 2002.
    116. [Abs]

  116. Wilson, W.H., Grossbard, M.L., Pittaluga, S., Cole, D., Pearson, D., Drbohlav, N., Steinberg, S.M., Little, R.F., Janik, J., Gutierrez, M., Raffeld, M., Staudt, L., Cheson, B.D., Longo, D.L., Harris, N., Jaffe, E.S., Chabner, B.A., Wittes, R., Balis, F. Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy. Blood. 99(8): 2685-2693, 2002.
    117. [Article]

  117. Yang, F., Li, X., Sharma, M., Sasaki, C.Y., Longo, D.L., Lim, B., Sun, Z. Linking �-catenin to androgen-signaling pathway. J. Biol. Chem. 277(13): 11336-11344, 2002.
    118. [Abs]

  118. Adamson, J.W., and Longo, D.L. Anemia and polycythemia. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison's Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 348-354.

  119. Armitage, J.O., and Longo, D.L. Malignancies of lymphoid cells. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison's Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 715-727.

  120. Crow, M., Taub, D.D., Cooper, S., Broxmeyer, H.E., Sarris, A.H. Human recombinant interferon-inducible protein-10: intact disulfide bridges are not required for inhibition of hematopoietic progenitors and chemotaxis of T lymphocytes and monocytes. J. Hematother. Stem. Cell. Res.10(1): 147-156, 2001.
    121. [Abs]

  121. Fauci, A.S., and Longo, D.L. The human retroviruses. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison's Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 1131-1135.

  122. Feng, Y., Longo, D.L., Ferris, D.K. Polo-like kinase interacts with proteasomes and regulates their activity. Cell. Growth Differ. 12(1): 29-37, 2001.
    123. [Abs]

  123. Fenton, R.G., and Longo, D.L. Cell biology of cancer. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison's Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 509-517.

  124. Henry, P.H., and Longo, D.L. Enlargement of lymph nodes and spleen. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison's Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 360-365.

  125. Janik, J.E., Miller, L.L., Korn, E.L., Stevens, D., Curti, B.D., Smith, J.W., 2nd, Sznol, M., Conlon, K.C., Sharfman, W., Urba, W.J., Gause, B.L., Longo, D.L. A prospective randomized phase II trial of GM-CSF priming to prevent topotecan-induced neutropenia in chemotherapy-naive patients with malignant melanoma or renal cell carcinoma. Blood 97(7): 1942-1946, 2001.
    126. [Abs]

  126. Lillard, J.W. Jr, Boyaka, P.N., Taub, D.D., McGhee, J.R. RANTES potentiates antigen-specific mucosal immune responses. J. Immunol. 166(1):162-9, 2001.
    127. [Abs]

  127. Liu, K., Hodes, R.J. and Weng, N. Cutting edge: Telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation. J. Immunol. 166: 4826-4830, 2001.
    128. [Abs]

  128. Liu, K., Li, Y., Prabhu, V., Young, L., Becker, K.G., Munson, P.J. and Weng, N.P. Augmentation in expression of activation-induced genes differentiates memory from naive CD4+ T cells and is a molecular mechanism for enhanced cellular response of memory CD4+ T cells. J. Immunol. 166(12):7335-7344, 2001.
    129. [Abs]

  129. Longo, D.L. Approach to the patient with cancer. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison's Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 491-497.

  130. Longo, D.L. Hodgkin�s disease: chemotherapy. In: Rakel, R.E., and Bope, E.T. (Eds.): Conn�s Current Therapy 2001, Philadelphia, W.B. Saunders, 2001, pp 429-435.

  131. Longo, D.L. Plasma cell disorders. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison's Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 727-733.

  132. Luo, Y., Long, J.M., Spangler, E.L., Longo, D.L., Ingram, D.K., and Weng, N.P. Identification of maze learning associated genes in rat hippocampus by cDNA microarray. J. Mol. Neurosci. 17: 127-134, 2001.
    133. [Abs]

  133. Mayne, M., Cheadle, C., Soldan, S.S., Cermelli, C., Yamano, Y., Akhyani, N., Nagel, J.E., Taub, D.D., Becker, K.G., Jacobson, S. Gene expression profile of herpesvirus-infected T cells obtained using immunomicroarrays: induction of proinflammatory mechanisms.J. Virol. 75(23): 11641-11650, 2001.
    134. [Abs]

  134. Murphy, W.J., and Longo, D.L. Alternative strategies other than growth hormone for the treatment of immune diseases. Trends Immunol. 22: 15-16, 2001.

  135. Murphy, W.J., Koh, C.Y., Raziuddin, A., Bennett, M., and Longo, D.L. Immunobiology of natural killer cells and bone marrow transplantation: merging of basic and preclinical studies. Immunol. Rev. 181: 279-289, 2001.
    136. [Abs]

  136. Perry, M.C., and Longo, D.L. Late consequences of cancer and its treatment. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison's Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 650-653.

  137. Sausville, E.A., and Longo, D.L. Principles of cancer treatment. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison's Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 530-547.

  138. Srivastava, R.K., Mattson, M.P., and Longo, D.L. Cytoskeletal involvement in apoptosis. In: Mattson, M.P., Estus, S., and Rangnekar, V.M. (Eds.): Programmed Cell Death Volume I Cellular and Molecular Mechanisms, Amsterdam, Elsevier, 2001, pp. 237-267.

  139. Tiberghien, P., Ferrand, C., Lioure, B., Milpied, N., Angonin, R., Deconinck, E., Certoux, J-M., Robinet, E., Saas, P., Petracca, B., Juttner, C., Reynolds, C.W., Longo, D.L., Herve, P., and Cahn, J-Y. Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft. Blood 97: 63-72, 2001.

  140. The Editors: The practice of medicine. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison's Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 1-5.

  141. Westin, E.H., and Longo, D.L. T-small cell disorders. Curr. Treat. Options Oncol. 2: 225-235, 2001.

  142. Alexandroff, A.B., Jackson, A.M., Paterson, T., Haley, J.L., Ross, J.A., Longo, D.L., Murphy, W.J., James, K., Taub, D.D. Role for CD40-CD40 ligand interactions in the immune response to solid tumours. Mol. Immunol. 37(9): 515-526, 2000.
    143. [Abs]

  143. Arun, B., Curti, B.D., Longo, D.L., Stevens, D., Alvord, W.G., Gause, B.L., Watson, T., Kopp, W.C., Janik, J.E. Elevations in serum soluble interleukin-2 receptor levels predict relapse in patients with hairy cell leukemia. Cancer J. Sci. Am. 6: 21-24, 2000.
    144. [Abs]

  144. Chase, D., Serafinas, C., Ashcroft, N., Kosinski, M., Longo, D., Ferris, D.K., Golden. A. The polo-like kinase PLK-1 is required for nuclear envelope breakdown and the completion of meiosis in Caenorhabditis elegans. Genesis 26: 26-41, 2000.
    145. [Abs]

  145. Dunn, B.K., and Longo, D.L. Molecular biology and biological markers. In: Hunter, C.P., Johnson, K.A., and Muss, H.B. (Eds.): Cancer in the Elderly, New York, Marcel Dekker, 2000, pp. 69-121.

  146. Kalechman, Y., Longo, D.L., Catane, R., Shani, A., Albeck, M., Sredni, B. Synergistic anti-tumoral effect of paclitaxel (taxol)+AS101 in a murine model of B16 melanoma: association with ras-dependent signal-transduction pathways. Int. J. Cancer 86(2): 281-288, 2000.
    147. [Abs]

  147. Kalehua, A.N., Taub, D.D., Baskar, P.V., Hengemihle, J., Munoz, J., Trambadia, M., Speer, D.L., De Simoni, M.G., Ingram, D.K. Aged mice exhibit greater mortality concomitant to increased brain and plasma TNF-alpha levels following intracerebroventricular injection of lipopolysaccharide. Gerontology. 46(3): 115-128, 2000.
    148. [Abs]

  148. Kaufman, D., and Longo, D.L. Hodgkin�s disease. In: Abeloff, M.D., Armitage, J.O., Lichter, A.S., and Niederhuber, J.E. (Eds.): Clinical Oncology, 2nd Edition. Philadelphia, Churchill-Livingstone, 2000, pp. 2620-2657.

  149. Kenny, J. J., Derby E.G., Yoder, J.A., Hill, S.A., Fischer, R.T., Tucker, P.W., Claflin, J.L., Longo, D.L. Positive and negative selection of antigen-specific B cells in transgenic mice expressing variant forms of the V(H)l (T15) heavy chain. Int. Immunol. 12(6): 873-885, 2000.
    150. [Abs]

  150. Kenny, J.J., Lustig, A., and Longo, D.L. Positive selection of low affinity autoreactive B cells. Curr. Top. Microbiol. Immunol. 252: 39-45, 2000.
    151. [Abs]

  151. Kenny, J. J., Rezanka, L.J., Lustig, A., Fischer, R.T., Yoder, J., Marshall, S., Longo, D.L. Autoreactive B cells escape clonal deletion by expressing multiple antigen receptors. J. Immunol. 164(8): 4111-4119, 2000.
    152. [Abs]

  152. Kondo, T., Morita, K., Watarai, Y., Auerbach, M.B., Taub, D.D., Novick, A.C., Toma, H., Fairchild, R.L. Early increased chemokine expression and production in murine allogeneic skin grafts is mediated by natural killer cells. Transplantation. 69(5): 969-77, 2000.
    153. [Abs]

  153. Longo, D.L. Lymphomas: complexity, not chaos. Curr. Opin. Oncol. 12(5): 379-382, 2000.

  154. Longo, D.L., Duffey, P.L., Gribben, J.G., Jaffe, E.S., Curti, B.D., Gause, B.L., Janik, J.E., Braman V.M., Esseltine, D., Wilson, W.H., Kaufman, D, Wittes, R.E., Nadler, L.M., and Urba, W.J. Combination chemotherapy followed by an immunotoxin (anti-B4-blocked ricin) in patients with indolent lymphoma: results of a phase II study. Cancer J. Sci. Am. 6: 146-150, 2000.
    155. [Abs]

  155. Mi, Q.S., Zhou, L., Schulze, D.H., Fischer, R.T., Lustig, A., Rezanka, L.J., Donovan, D.M., Longo, D.L., Kenny, J. J. Highly reduced protection against streptococcus pneumoniae after deletion of a single heavy chain gene in mouse. Proc. Natl. Acad. Sci. USA 97(11): 6031-6036, 2000.
    156. [Abs]

  156. Murphy, W.J., Longo, D.L. Growth hormone as an immunomodulating agent. Immunol. Today 21: 211-213, 2000.
    157. [Abs]

  157. Nilsson, G., Metcalfe, D.D., Taub, D.D. Demonstration that platelet-activating factor is capable of activating mast cells and inducing a chemotactic response. Immunology. 99(2):314-319, 2000.
    158. [Abs]

  158. Raziuddin, A., Bennett, M., Winkler-Pickett, R., Ortaldo, J.R., Longo, D.L., and Murphy, W.J. Synergistic effects of in vivo depletion of Ly-49A and Ly-49G2 natural killer cell subsets in the rejection of H-2b bone marrow allografts. Blood 95: 3840-3844, 2000.
    159. [Abs]

  159. Sasaki, C.Y., Lin, H., Morin, P.J., and Longo, D.L. Truncation of the extracellular region abrogates cell contact but retains the growth suppressive activity of E-cadherin. Cancer Res. 60: 7057-7065, 2000.

  160. Son, N., Murray, S., Yanovski, J. Hodes, R.J. and Weng, N. Lineage specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age. J. Immunol. 165: 1191-1196, 2000.
    161. [Abs]

  161. Sredni, B., Longo, D.L., Catane, R., Shani, A., Albeck, M., and Kalechman, Y. Synergistic antitumoral effect of the immunomodulator AS101 plus paclitaxel (Taxol). Association with ras-dependent signal transduction pathways. Exp. Hematol. 28: 1496, 2000.
    162. [Abs]

  162. Taub, D.D. Modified microchemotaxis assays. Methods Mol. Biol. 138: 105-112, 2000.
    163. [Abs]

  163. Weng, N. and Hodes, R.J. The role of telomerase expression and telomere length maintenance in human and mouse. J. Clin. Immunol. 20(4):257-267, 2000.
    164. [Abs]

IRP Home     What's New     Contact Us     Accessibility     Disclaimer     Privacy     Site Search     Site Map     NIA Home    
NIH logo-link to NIH Home Page DHHS logo-link to DHHS Web Site FirstGov logo-link to FirstGov Web Site
Updated: Thursday October 11, 2007