Publicly available data from the NCI Yeast Anticancer Drug Screen
Stage2 IC50 patterns and dose-response curves.
From each of the following tables you will be able to retrieve a page with 2 graphs of Stage2 data for a chosen compound. Most of the tables also provide links to search for screening data from the NCI 60 Human Tumor Cell Line Screen and for 3D structures of the compounds. Stage2 data are available for 2,189 compounds.
- The data is presented as a graph of the IC50 values relative to the appropriate control strain. The values shown are the difference in the negative of the log of the IC50. Positive values represent compounds that inhibit a given strain more than they do the control strain. (For example a value of 1.0 would result if a compound inhibited a test strain 10-fold more than it inhibited the wild type control.) The values are shown to the right of the graph.
- The data is also presented as a dose response curve of relative growth (yeast strain with drug relative
to no drug control).
- Stage2 data: Retrieve a table of selective compounds that inhibit a given yeast strain (growth inhibition
of 70% or more) at one or more of the tested doses. These tables provide data for compounds that inhibit only
the chosen strain for at least one of the tested doses, as well as compounds that inhibit the chosen strain
PLUS several other strains.
- bub3 Mitotic spindle checkpoint: 175 compounds
- CLN2oe G1 cyclin: 41 compounds
- mec2 S/G2 checkpoint kinase: 110 compounds
- mgt1 O6-methyl G repair: 82 compounds
- mlh1 DNA mismatch repair: 64 compounds
- rad14 UV-excision repair: 181 compounds
- rad18 Post-replication repair: 423 compounds
- rad50 Recombinational repair: 495 compounds
- rad52 Recombinational repair: 453 compounds
- sgs1 Helicase: 262 compounds
- Multiple strains : 84 compounds
- Stage2 data: Retrieve tables of strains inhibited at each dose for all compounds tested in Stage2. The
growth of the listed strain(s) was inhibited by at least 70%. Data are available for 2,189 compounds, split
into several tables.
- 1st 300 compounds (NSC 632 - NSC 97374)
- Next 300 compounds (NSC 97388 - NSC 147237)
- Next 300 compounds (NSC 150169 - NSC 294440)
- Next 300 compounds (NSC 294743 - NSC 400540)
- Next 300 compounds (NSC 400541 - NSC 602613)
- Next 300 compounds (NSC 602889 - NSC 652815)
- Next 300 compounds (NSC 652884 - NSC 674561)
- Final 89 compounds (NSC 674565 - NSC 709257)
Email questions to: Susan Holbeck [holbecks@mail.nih.gov]