Gene	Syndrome	Hereditary Pattern	Predominant Cancer
Tumor suppressor genes
APC (OMIM)	FAP (OMIM)	Dominant	Colon, intestine, etc.
AXIN2 (OMIM)	Attenuated polyposis (OMIM)	Dominant	Colon
TP53 (p53) (OMIM)	Li-Fraumeni (OMIM)	Dominant	Multiple (including colon)
STK11 (OMIM)	Peutz-Jeghers (OMIM)	Dominant	Multiple (including intestine)
PTEN (OMIM)	Cowden (OMIM)	Dominant	Multiple (including intestine)
BMPR1A (OMIM)	Juvenile polyposis (OMIM)	Dominant	Gastrointestinal
SMAD4 (DPC4) (OMIM)	Juvenile polyposis (OMIM)	Dominant	Gastrointestinal
Repair/Stability genes
hMLH1 (OMIM), hMSH2(OMIM), hMSH6(OMIM), PMS2 (OMIM)	Lynch (OMIM)	Dominant	Multiple (including colon, uterus, and others)
MYH (MutYH) (OMIM)	Attenuated polyposis (OMIM)	Recessive	Colon
BLM (OMIM)	Bloom (OMIM)	Recessive	Multiple (including colon)
Oncogenes
KIT (OMIM)	Familial GI stromal tumor (OMIM)		GI stromal tumors
PDGFRA (OMIM)	Familial GI stromal tumor (OMIM)		GI stromal tumors

FAP = familial adenomatous polyposis; GI = gastrointestinal; OMIM = Online Mendelian Inheritance in Man database.

Adapted from Vogelstein et al.[2]

References

2. Vogelstein B, Kinzler KW: Cancer genes and the pathways they control. Nat Med 10 (8): 789-99, 2004.  [PUBMED Abstract]