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Sponsored by: |
National Institute on Aging (NIA) |
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Information provided by: | National Institute on Aging (NIA) |
ClinicalTrials.gov Identifier: | NCT00104312 |
The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.
Condition |
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Osteoarthritis |
Study Type: | Observational |
Study Design: | Cohort, Cross-Sectional |
Official Title: | Weakness From Inflammation: A Basis of Disability From Knee Osteoarthritis |
Synovial fluid and tissue blood serum muscle biopsy
Estimated Enrollment: | 88 |
Study Start Date: | April 2001 |
Estimated Study Completion Date: | December 2012 |
Estimated Primary Completion Date: | December 2012 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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1
Participants with symptomatic knee osteoarthritis
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Participants without symptomatic knee osteoarthritis, age-matched as controls
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Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure.
This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery.
Participation in this study is entirely voluntary.
Ages Eligible for Study: | 50 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Community - Men and women
Inclusion Criteria:
Exclusion Criteria:
Contact: NIA Recruiter | 410-350-3941 or 800-225-2572 ext 3941 | NIAStudiesRecruitmetmn@mial.nih.gov |
United States, Maryland | |
Harbor Hospital | Recruiting |
Baltimore, Maryland, United States, 21225 | |
Contact: NIA Recruiter 410-350-3941 NIASTudiesRecruitment@mail.nih.gov | |
Principal Investigator: Shari Ling, MD |
Principal Investigator: | Shari Ling, MD | NIA, Johns Hopkins Medical Institution Divisions of Rheumatology, Gerontology, and Geriatrics |
Responsible Party: | National Institute on Aging ( Shari Ling, MD, Principal Investigator ) |
Study ID Numbers: | AG0016 |
Study First Received: | February 24, 2005 |
Last Updated: | August 22, 2008 |
ClinicalTrials.gov Identifier: | NCT00104312 |
Health Authority: | United States: Federal Government |
Knee Osteoarthritis Muscle Cytokine Mobility Function |
Osteoarthritis, Knee Musculoskeletal Diseases Asthenia Osteoarthritis |
Joint Diseases Arthritis Rheumatic Diseases Inflammation |
Pathologic Processes |