NIDCR, NIH, 10 Center Drive
Bldg. 10, Room 1N-114, MSC 1190
Bethesda, MD 20892
Tel: (301) 402-3118
Fax: (301) 402-1228
E-mail: nikolovn@mail.nih.gov
Research Interests:
Clinical and translational research on the pathogenesis and treatment of Sjögren’s syndrome, systemic lupus erythematosus and other rheumatic diseases
Boards:
ABIM, Internal Medicine Certified
ABIM, Rheumatology Certified
Education:
M.D., Medical University Sofia, Bulgaria
M.H.S., NIH-Duke Clinical Research Training Program
Current Position:
Staff Clinician, Sjögren’s Syndrome Clinic, NIDCR, MPTB, NIH, Bethesda, MD
Honors/Awards:
August 2006 Fellows Award for Research Excellence (FARE) 2007, NIH, Bethesda, MD
July 2005 NIH Bench-to-Bedside Award, Pathogenesis of and risk factors for autoimmunity in the Wiskott-Aldrich
Syndrome, NIAMS, NIH, Bethesda, MD
May 2005 RSDC Fellow’s Forum Podium Presentation Award, Bethesda, MD
Nov. 1995 Summa Cum Laude -Medical University Sofia, Bulgaria
Nov. 1995 Golden Hippocrates Award-Medical University Sofia, Bulgaria
Sept. 1995 NUFFIC (The Netherlands Organization for Cooperation in Higher Education) Scholarship
Current Research:
Principal Investigator: Clinical and Laboratory Evaluation of the Autonomic Nervous System in Primary Sjögren’s Syndrome, NIDCR, NIH (08-D-0018)
Lead Associate Investigator: Open-label, Dose escalation study of AdhAQP1 parotid gene transfer for radiation-induced salivary gland dysfunction, NIDCR, NIH (06-D-0206)
Lead Associate Investigator: A Randomized, Placebo Controlled, Proof of Concept, Study of Raptiva, a Humanized Anti-CD11a Monoclonal Antibody, in Patients with Sjogren’s Syndrome, NIDCR, NIH (06-D-0181)
Associate Investigator: A Pilot Study of Intensified Lymphodepletion Followed by Autologous Hematopoietic Stem Cell Transplantation in Patients with Severe SLE, NIAMS, NIH (04-C-0095),
Publications:
Nikolov NP, Pavletic, SZ-Haematopoietic Stem Cell Transplantation for Systemic Rheumatic Diseases-Nature, Clinical Practice Rheumatology-in press
Siegel RM, Vioritto ICB, Nikolov NP-Autoimmunity versus tolerance: Can dying cells tip the balance?-Journal of Clinical Immunology- 2007 Feb;122(2):125-34
Nikolov NP, Smith JA, Patronas NJ, Illei GG-SLE-Associated CNS Vasculitis-Nature, Clinical Practice Rheumatology-2006 Nov;2(11):627-33
Nikolov NP, Bailey D, Candotti F, Schwartzberg PL, Strom T, Siegel RM-Autoimmunity and Impaired T Cell Apoptosis in
Wiskott-Aldrich Syndrome Protein Deficiency: A Fas Ligand Connection-Arthritis and Rheumatism, Vol. 54:9, 2006, S749
Nikolov NP, Illei GG, Yarboro C, Hakim F, Leitman S, Balow J, Austin H, Gea-Banacloche J, Muraro P, Babb R, Sportes C,
Lipsky PE, Gress R, Pavletic SZ-Effective Immune Depletion Following Novel Lymphoablative Regimen for Autologous Hematopoietic Stem Cell Transplantation in SLE-Arthritis and Rheumatism, Vol. 54:9, Sept. 2006, S790
Muraro P, Nikolov NP, Butman JA, Abati A, Gea-Banacloche J, Gress R, Lipsky PL, Illei GG, Pavletic S-Granulocytic invasion of the CNS after Autologous Hematopoietic Stem Sell Transplantation for Severe Lupus-Haematologica 2006 Jun;91(6 Suppl):ECR21
Nikolov NP, Siegel RM-All in the family: The TNF-TNFR superfamily in the pathogenesis and treatment of rheumatoid arthritis and other inflammatory diseases, Current Medicinal Chemistry-Vol.4:6, Dec. 2005, 587-596
Yazici Y, Erkan D, Harrison MJ, Nikolov NP, Paget SA-MTX use in RA is associated with few clinically significant liver function test abnormalities-Clinical and Experimental Rheumatology 23(4), 2005, 517-520
Ward J, Nikolov NP, Tschetter J, Kopp J, Gonzalez F, Kimura S, Siegel RM-Progressive Glomerulonephritis and Histiocytic Sarcoma Associated With Macrophage Functional Defects in CYP1B1 Deficient Mice-Toxicologic Pathology, 32:710–718, 2004
Nikolov NP, Siegel RM-Cytochrome P450 1B1 Enzyme Deficiency and Autoimmunity in Mice-Arthritis and Rheumatism, Vol. 50: 9, Sept 2004, S683-84
Ramaswamy D, Gnanarekaran I, Nikolov NP, Efthimiou P, Gour N, Paget S-Musculoskeletal Manifestations in Patients on Hemodialysis for ESRD: A Profound Change in the Character and Incidence Associated with Advancements in Dialysis Therapy, Arthritis and Rheumatism, Vol. 48:9, Sept 2003, S533