NATIONAL INSTITUTES OF HEALTH/NIDCR
BUILDING 30 ROOM 523A
30 CONVENT DR MSC 4326
BETHESDA MD 20892-4326
Phone: (301) 435-6234
Fax: (301) 480-5353
E-mail: Dr. Lynne M. Angerer
Education
1973-1977: Postdoctoral Fellow, Division of chemistry, California Institue of Technology, Pasadena, California
1973: Ph.D., Department of biology, The Johns Hopkins University
1967: M.Sc., Department of Zoology and Entomology, The Ohio State University, Columbus, OH
Recent publications
Angerer, L.M. and Angerer, R.C. “Regulative development of the sea urchin embryo: signalling cascades and morphogen gradients.” Sem. Cell & Dev. Biol. 10: 327-334(1999).
Kenny, A.P*., Kozlowski, D.J*., Oleksyn, D.W., Angerer, L.M. and Angerer, R.C. “SpSoxB1, a maternally encoded transcription factor asymmetrically distributed among early sea urchin blastomeres.” Development 126: 5473-5483 (1999) .
Angerer, L.M., Oleksyn, D., Dale, L. and Angerer, R.C. “A BMP4 pathway regulates cell fate allocation along sea urchin embryonic axes.” Development 127: 1105-1114 (2000).
Angerer, R.C. and Angerer, L.M. “Sea urchin embryo: specification of cell fate.” Encyclopedia of Life Sciences, Macmillan Reference Ltd (2000).
Angerer, L.M. and Angerer, R.C. “Animal-vegetal axis patterning mechanisms in the early sea urchin embryo.” Dev. Biol 218: 1-12 (2000).
Howard, E.W., Newman, L.A., Oleksyn, D.W., Angerer, L.M. and Angerer, R.C. “SpKrl: a direct target of b-catenin regulation required for endoderm differentiation in sea urchin embryos.” Development 128: 365-375 (2001) .
Kenny, A.P., Angerer, L.M. and Angerer, R.C. “SpSoxB1 serves an essential architectural function in the promoter SpAN, a tolloid/BMP1-related gene.” Gene Expression 9: 283-290 (2001).
Angerer, L.M., Oleksyn, D.W., Levine, A., Li, X., Klein, W.H. and Angerer, R.C. “Sea urchin goosecoid function links fate specification along the animal-vegetal and oral-aboral embryonic axes.” Development 128: 4393-4404 (2001).
Angerer, L.M. and Angerer, R.C. “Patterning the sea urchin embryo: gene regulatory networks, signaling pathways and cellular interactions.” Current Topics Dev. Biol. 53: 159-198 (2001).
Kenny, A.P., Oleksyn E.W., Newman, L. A., Angerer, R.C. and Angerer, L.M. “Tight regulation of SoxB factors is required for for patterning and morphogenesis in sea urchin embryos.” Dev. Biol. 261: 412-425 (2003).
Angerer, L.M. and Angerer, R.C “Disruption of gene function using antisense morpholinos.” Methods in Cell Biology, chapter 28, pp. 628-711 (2004).
Angerer, LM., Newman, L.A., Oleksyn, D.W. and Angerer, R.C. “SoxB1 down regulation in vegetal lineages of sea urchin embryos is achieved by both transcriptional repression and selective protein turnover.” Development 132: 999-1008 (2005).
Wei, Z., Angerer, R.C. and Angerer, L.M. (2006) A database of mRNA expression patterns for the sea urchin embryo. Dev. Biol. 300, 476-484.
Lepage, T., Lapraz, F, Rottinger, E., Duboc, V., Range, R., Duoquin, L., Waltong, K., Wu, S-Y, Bradham, C., Whittaker, C., Loza, M., Hibino, T, Wilson, K., Poustka, A, McClay, D., Angerer, L., Gache, C. (2006) Genes for receptor Trosine kinases and TGF-b singaling patways encoded in the sea urchin genome. Dev. Biol. 300, 132-152.
Angerer, L., Hussain, S., Wei, Z., and Livingston, B.T. (2006) Sea urchin metalloproteases: a genomic survey of the tolloid-like, MMP and ADAM families. Dev. Biol. 300, 267-281.
Burke, R.D., Angerer, L.M., Elphick, M.R., Humphrey, G.W., Yaguchi, S.S., Kiyama, T., Liang, S., Mu, X., Agca, C., Klein, W.H., Brandhorst, B.P., Rowe, M., Wilson, K., Churcher, A.M., Taylow, J.S., Chen, N., Murray, G., Wang, D.Y., Mellott, D., Hallbook, F., Olinski, R., Thorndyke, M.C. (2006) A genomic view of the sea urchin nervous system. Dev. Biol. 300, 434-460.
Sea Urchin Genome Sequencing Consortium (2006) The genome of the sea urchin Strongylocentrotus purpuratus. Science 300, 914-952.
Dunn, E.F., Moy, V.N., Angerer, L.M., Angerer, R.C., Morris, R.L. and Peterson, K.J. (2006), Molecular paleoecology: Using gene regulatory analysis to address the origins of complex life cycles in the late Precambrian. Evol. Dev., in press.
Angerer, R.C. and Angerer, L.M. “Sea urchin embryo: specification of cell fate.” Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester http://www.els.net/
Angerer, L.M., Kenny, A.P., Newman, L.A. and Angerer, R.C. (2006) Mutual antagonism of SoxB1 and canonical Wnt signaling in sea urchin embryos. Cell Signaling, Wiley Interscience, in press.
Complete CV and Publications