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Abstract

Grant Number:	5K24AT000596-10
Project Title:	Clinical Studies in Nutrition and Metabolism

PI Information:	Name	Email	Title
	JIALAL, ISHWARLAL	ishwarlal.jialal@ucdmc.ucdavis.edu	PROFESSOR AND CHAIR

Abstract: DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of morbidity and mortality in the United States. Oxidative Stress and Inflammation play a pivotal role in atherogenesis. CANDIDATE: In the funded K24 Award (Year 4), the principal investigator has made excellent progress with respect to productivity (publications and procuring grants), mentoring and enhancing his research program. RESEARCH PLAN: In the present proposal, which aims to further strengthen his research program and mentoring in patient-oriented research, the principal investigator proposes the following studies: 1) The Effect of High dose Alpha tocopherol Supplementation on Oxidative Stress (OS), Inflammation and Carotid Atherosclerosis in Patients with Coronary artery disease ; 2) Monocyte Function and Inflammation in Type 1 Diabetes and its Modulation with Simvastatin therapy; 3) The Effect of Simvastatin Therapy on Monocytic Inflammatory Markers and hsCRP Levels in Patients with the Metabolic Syndrome; 4) A Dose-Response Effect of Lycopene supplementation on Biomarkers of OS; 5) Effect of Alpha tocopherol and Gamma tocopherol Supplementation on Biomarkers of OS and Inflammation in Patients with the Metabolic Syndrome. Biomarkers of OS that will be analyzed include urinary F2-isoprostanes, LDL oxidative susceptibility; biomarkers of inflammation will include hs-CRP, SAA, plasma soluble cell adhesion molecules, monocyte superoxide anion release, cytokine release, adhesion to endothelium. MENTORING PLAN: These focused and cohesive clinical studies in Nutrition and Metabolism, in addition to the didactic courses and Mentored Clinical Research Training Program offered at UC-Davis will provide an excellent training ground for the junior faculty and clinical fellows in the area of patient-oriented research. Thus, studies outlined in this proposal will clearly enhance the long-term objectives of the principal investigator, since his major interest is in the area of lipoproteins, oxidative stress and inflammation in diabetes and atherosclerosis and their modulation.

Public Health Relevance:
This Public Health Relevance is not available.

Thesaurus Terms:
antioxidant, atherosclerosis, blood lipoprotein metabolism, dietary supplement, oxidative stress, postgraduate education, tocopherol
antihypercholesterolemic agent, cell adhesion molecule, dietary lipid, disease /disorder proneness /risk, flavonoid, inflammation, leukocyte activation /transformation, lipoxygenase, low density lipoprotein, nuclear factor kappa beta, protein kinase C, racial /ethnic difference, unsaturated fatty acid
alternative medicine, clinical research, human subject, nutrition related tag, plant extract

Institution:	UNIVERSITY OF CALIFORNIA DAVIS
	OFFICE OF RESEARCH - SPONSORED PROGRAMS
	DAVIS, CA 95618
Fiscal Year:	2008
Department:	PATHOLOGY & LABORATORY MEDICINE
Project Start:	01-JUL-2005
Project End:	30-JUN-2010
ICD:	NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE
IRG:	ZAT1

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