Posing Questions, Finding Answers
Selected Readings
Clark,W.R., A Means to an End: The Biological Basis of Aging and Death, New York: Oxford University Press, 2002.
Ricklefs, R.E., and Finch, C.E., Aging: A Natural History, New York: W.H. Freeman and Company, 1995.
Austad, S.N., Why We Age: What Science Is Discovering about the Body’s Journey Through Life, New York: John Wiley & Sons, 1997.
Kirkwood, T., Time of Our Lives, New York: Oxford University Press, 2000.
Rowe, J.W., and Kahn, R.L., Successful Aging, New York: Random House, 1998.
Hayflick, L., How and Why We Age, New York: Ballantine, 1994.
Finch, C.E., Longevity, Senescence and the Genome, Chicago: University of Chicago Press, 1991.
Institute of Medicine, Extending Life, Enhancing Life: A National Research Agenda on Aging, Washington, DC: National Academy Press, 1991.
Martin, G.R., Baker, G.T., “Aging and the Aged: Theories of Aging and Life Extension,” Encyclopedia of Bioethics, New York: MacMillan, 1993.
Warner, H.R., Butler, R.N., Sprott, R.L., and Schneider, E.L., eds., Modern Biological Theories of Aging, New York: Raven, 1987.
The Genetic Connection
Selected Readings
Blackburn, E.H., “Telomere States and Cell Fates,” Nature 408(6808):53-56, 2000.
Sprott, R.L, and Pereira-Smith, O.M. eds., “The Genetics of Aging,” Generations: Journal of the American Society on Aging, 24:11-88, 2000.
Guarente, L., and Kenyon, C., “Genetic Pathways That Regulate Aging in Model Organisms,” Nature 408(6809): 255-262, 2000.
Finch C.E., and Tanzi, R.E., “Genetics of Aging,” Science, 278(5337): 407-411, 1997.
Rudolph, K.L., et al., “Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice,” Cell, 965: 701-12, 1999.
Hodes, R.J., McCormick, A.M., and Pruzan, M., “Longevity Assurance Genes: How Do They Influence Aging and Lifespan,” Journal of the American Geriatrics Society, 448:988-991, 1996.
Rubin, H., “Cell Aging In Vivo and In Vitro,” Mechanisms of Aging and Development, 981:1-35, 1997.
Perls, T., et al., “Exceptional Familial Clustering for Extreme Longevity in Humans,” Journal of the American Geriatrics Society, 48(11):1483-1485, 2000.
Harley, C.B., Futcher, A.B., and Greider, C.W., “Telomeres Shorten During Aging of Human Fibroblasts,” Nature 345:458-460, 1990.
Hayflick, L., and Moorhead, P.S., “The Serial Cultivation of Human Diploid Cell Strains,” Experimental Cell Research 25:585-621, 1961.
Jazwinski, S.M., “Genes of Youth: Genetics of Aging in Baker’s Yeast,” ASM News 59:172-178, 1993.
Johnson, T.E., “Aging Can Be Genetically Dissected into Component Processes Using Long-Lived Lines of Caenorhabditis elegans,” Proceedings of the National Academy of Sciences 84:3777-3781, 1987.
McCormick, A.M., and Campisi, J., “Cellular Aging and Senescence,” Current Opinion in Cell Biology 3:230-234, 1991.
Pereira-Smith, O.M., and Smith, J.R., “Genetic Analysis of Indefinite Division in Human Cells: Identification of Four Complementation Groups,” Proceedings of the National Academy of Sciences 85:6042-6046, 1988.
Rose, M.R., “Laboratory Evolution of Postponed Senescence in Drosophila Melanogaster,” Evolution 38:1004-1010, 1984.
Biochemistry and Aging
Selected Readings
Finkel, T., and Holbrook, N.J., “Oxidants, Oxidative Stress and the Biology of Aging,” Nature 408(6809):239-247, 2000.
Beckman, K.B., and Ames, B.N., “The Free Radical Theory of Aging Matures,” Physiological Reviews 78(2): 547-581, 1998.
Phillips, J.P., Parkes, T.L., and Hilliker, A.J., “Targeted Neuronal Gene Expression and Longevity in Drosophila,” Experimental Gerontology 35(9-10):1157-1164, 2000.
Tower, J., “Transgenic Methods for Increasing Drosophila Life Span,” Mechanisms of Aging and Development 118(1-2):1-14, 2000.
Melov, S., et al., “Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics,” Science 289(5484):1567-1569, 2000.
Knight, J.A., “The Biochemistry of Aging,” Advances In Clinical Chemistry, 35:1-62, 2000.
Campisi, J., and Warner, H.R., “Aging in Mitotic and Post-Mitotic Cells,” in Gilchrest, B.A., and Bohr, V.A., eds., The Role of DNA Damage and Repair in Cell Aging, New York: Elsevier Science, 2001.
Ames, B.N., “Endogenous DNA Damage as Related to Nutrition and Aging,” in Ingram, D.K., Baker, G.T., and Shock, N.W., eds., The Potential for Nutritional Modulation of Aging Processes, Trumbull, CT: Food and Nutrition Press, 1991.
Blake, M.J., Udelsman, R., Feulner, G.J., Norton, D.D., and Holbrook, N.J., “Stress-Induced HSP70 Expression in Adrenal Cortex: A Glucocorticoid Sensitive, Age-Dependent Response,” Proceedings of the National Academy of Sciences 87:846-850, 1991.
Cerami, A., “Hypothesis: Glucose as a Mediator of Aging,” Journal of the American Geriatrics Society 33:626-634, 1985.
Daynes R.A., and Araneo, B.A., “Prevention and Reversal of Some Age-Associated Changes in Immunologic Responses by Supplemental Dehydroepiandrosterone Sulfate Therapy,” Aging: Immunology, and Infectious Disease 3:135-153, 1992.
Harman, D., “The Free Radical Theory of Aging,” in Warner, H.R., et al., eds., Modern Biological Theories of Aging, New York: Raven, 1987.
Rudman, D., Feller, A.G., Nagraj, H.S., et al., “Effects of Human Growth Hormone in Men Over 60 Years Old,” The New England Journal of Medicine 323(1):1-6, 1990.
Stadtman, E.R., “Protein Oxidation and Aging,” Science 257:1220-1224, 1992.
Wallace, D.C., “Mitochondrial Genetics: AParadigm for Aging and Degenerative Diseases?” Science 256:628-632, 1992.
Physiologic Clues
Selected Readings
Biomarkers of Aging: From Primitive Organisms to Man, Workshop Report, International Longevity Center, 2001.
The Aging Factor in Health and Disease, Workshop Report, International Longevity Center, 1999.
Roth, G.S., Ingram, D.K., and Lane, M.A., “Calorie Restriction in Primates: Will It Work and How Will We Know?” Journal of the American Geriatrics Society, 47(7):896-903, 1999.
Mattson, M.P., “Neuroprotective Signaling and the Aging Brain: Take Away My Food and Let Me Run,” Brain Research 886(1-2):47-53, 2000.
Ramsey, J.J., et al., “Dietary Restriction and Aging in Rhesus Monkeys: The University of Wisconsin Study,” Experimental Gerontology 35(9-10):1131-1149, 2000.
Adler, W., Song, L., Chopra, R.K., Winchurch, R.A., Waggie, K.S., and Nagel, J.E., “The Immune Deficiency of Aging,” in Powers, D., Morley, J., and Coe, R., eds., Aging, Immunity, and Infection, New York: Springer, 1993.
Fiatarone, M.A., and Marks, E.C., et al., “High-Intensity Strength Training in Nonagenarians,” Journal of the American Medical Association 263:3029-3034, 1990.
National Institute on Aging, Research on Older Women: Highlights from the Baltimore Longitudinal Study of Aging, Bethesda, MD: National Institutes of Health, 1991.
Shock, N.W., Greulich, R.G., Andres, R.A., Arenberg, D., Costa, P.T., Lakatta, E.G., and Tobin, J.P., Normal Human Aging: The Baltimore Longitudinal Study of Aging, Washington, DC: U.S. Government Printing Office, 1984.
Warner, H.R., and Kim, S.K., “Dietary Factors Modulating the Rate of Aging,” in Goldberg, I., ed., Functional Foods, New York: Van Nostrand Reinhold, 1993.
Weindruch, R., and Walford, R.L., The Retardation of Aging and Disease by Dietary Restriction, Springfield, IL: Charles C. Thomas, 1988.
The Future of Aging
Selected Readings
K. Kinsella and V.A. Velkoff, U.S. Census Bureau, Series P95/01-1, An Aging World: 2001, U.S. Government Printing Office, Washington, D.C. 2001.
Federal Interagency Forum on Aging-Related Statistics. Older Americans 2000: Key Indicators of Well-Being. Federal Interagency Forum on Aging-Related Statistics, Washington, DC: U.S. Government Printing Office. August 2000.
Stem Cells: Scientific Progress and Future Research Directions, National Institutes of Health, Department of Health and Human Services, June 2001. http://stemcells.nih.gov/info/scireport
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