The FY 2003 President’s Budget for NIH (including AIDS) increases from $23,729,584,000 in FY 2002 to $27,432,075,000 in FY 2003, an increase of 15.6 percent. A substantial part of this increase will support new initiatives in bioterrorism research at the National Institute of Allergy and Infectious Diseases (NIAID). AIDS funding increases by 10.1 percent in FY 2003, from $2,514,954,000 in FY 2002 to $2,769,997,000.
The FY 2003 President's Budget for NIA (including AIDS) is $971,709,000 an increase of 8.4 percent over the FY 2002 amount of $896,064,000. Funding for AIDS related research increases from $4,985,000 in FY 2002 to $5,379,000 in FY 2003, an increase of 7.9 percent.
One of NIH’s highest priorities is the funding of medical research through research project grants (RPGs). Support for RPGs allows NIH to sustain the scientific momentum of investigator-initiated research while providing new research opportunities. The FY 2003 NIA request provides an average cost increase for competing RPGs at the Biomedical Research and Development Price Index (BRDPI), estimated at 4.0 percent. Noncompeting RPGs will receive increases of 3 percent on average for recurring direct costs.
The FY 2003 request includes funding for 1,456 research project grants, compared to 1,402 in FY 2002 and 1,276 in FY 2001. Of these 1,456 awards, 436 will be competing research project grants and 1,020 will be noncompeting awards. In addition, the request includes funding for 78 SBIR/STTR grants.
Funding for the Centers mechanism increases by 6.0 percent over the FY 2002 level.
Promises for advancement in medical research are dependent on a continuing supply of new investigators with new ideas. In the FY 2003 request, NIA will support 584 pre- and postdoctoral trainees in full-time training positions. An increase of 4.3 percent over FY 2002 levels is provided for stipends and training-related expenses (e.g., health insurance, research supplies and equipment, and travel to scientific meetings).
The FY 2003 request includes an increase of 7.8 percent over the FY 2002 level for Other Research. Most of this increase will support 192 positions in the Research Career Awards Program, including the AD Clinical Research and Training Awards initiative.
Funding for Contracts in FY 2003 increases by 6.9 percent over the FY 2002 level to support NIA’s share of the NIH Extramural Clinical Loan Repayment Program.
The FY 2003 request includes an 8.9 percent increase over the FY 2002 level for Intramural Research and an 8.8 percent increase over the FY 2002 level for Research, Management, and Support.
(Contact: Mr. Kevin Laser, BO, 301-496-9147)
S. 2766 – On July 18, 2002, the Senate Appropriations Subcommittee on Labor, HHS, Education reported out S. 2776, appropriations for the Departments of Labor, Health and Human Services, and Education for the fiscal year ending September 30, 2003. The bill includes a total of $27,192,926,000 for NIH. This represents an increase of $3,737,083,000 over the Fiscal Year 2002 level and $25,000,000 over the budget request. This appropriation will complete the historic five-year effort to double the funding for the NIH.
H.R. 4775 – On August 2, the President signed into law H.R. 4775, the 2002 Supplemental Appropriations Act for Further Recovery From and Response To Terrorist Attacks on the United States, as P.L. 107-206. This legislation provides $8 million in funding for NIEHS, but also includes rescissions affecting NIH. The Act also names in statute the National Research Service Awards as the Ruth L. Kirschstein National Research Service Awards.
S. 2794 – On July 25, Senator Phil Gramm (R-TX) introduced S. 2794, the Homeland Security Act of 2002. The bill, which is the Senate’s version of the President’s homeland security proposal, would establish a Department of Homeland Security. Research provisions would permit the Secretary of Homeland Security to carry out civilian human health-related biological, biomedical, and infectious disease defense research and development through the U.S. Department of Health and Human Services. Provisions would require the Secretary of Homeland Security to consult with the Secretary of HHS in setting research priorities. S. 2794 was referred to the Senate Committee on Governmental Affairs.
S. 2452 – On July 25, the Senate Committee on Governmental Relations (Joseph Lieberman [D-CT], Chairman) marked up and amended S. 2452, the National Homeland Security and Combating Terrorism Act of 2002, and ordered the measure to be reported. New provisions would authorize the Secretary of Homeland Security to carry out human health-related biological, biomedical and infectious disease research and development in collaboration with the Secretary of Health and Human Services. Research supported by funding appropriated to NIH would be required to be conducted through NIH under a joint strategic research plan and prioritization agreement between the two Secretaries.
H.R. 5005 – On July 26, the House passed with amendments H.R. 5005, the Department of Homeland Security Act of 2002. Provisions would authorize the new Department to conduct basic and applied research, development, demonstration, testing, and evaluations related to chemical, biological, radiological, and other emerging terrorist threats, provided that these activities do not extend to human health-related research and development. H.R. 5005 was considered in the Senate on July 31, where a cloture motion was offered to limit further consideration of the measure to 30 hours of debate.
Field Hearing on Healthy Aging and Nutrition -- On August 15, 2002, Dr. Pamela Starke-Reed, Deputy Director, NIH Division of Nutrition Research Coordination, testified at the request of Senator John Breaux (D-LA), Chairman, Senate Special Committee on Aging, at the Pennington Research Center in Baton Rouge, LA, on NIH research related to healthy aging and nutrition. (Contact: Ms. Barbara Kellner, OPAE, 301-496-3121)
The Immunology and Aging Workshop (advisory) was held June 13-14, 2002 in Bethesda to present and discuss major areas of research in aging of the immune system and vaccine effectiveness in the elderly. Presentations were followed by discussion of research areas that would benefit from further research efforts, resources that would facilitate research advances and limitations researchers are now encountering. In addition, strategies for recruiting more immunologists to these areas of research as well as plans for future workshops were discussed. A summary report is being circulated among workshop participants for comments. A final report will be made available to NIA staff and Council. (Contact: Dr. Rebecca Fuldner, BAP, ph: 301-496-6402)
Alzheimer’s Disease Neuroimaging Initiative. The Neuroscience and Neuropsychology of Aging Program (NNA) is in the process of developing an Alzheimer’s Disease Neuroimaging Initiative. It is being planned as a partnership among the NIA/NIH, academic investigators, the pharmaceutical industry, and the imaging equipment industry, with participation from the Alzheimer’s Association and the Institute for the Study of Aging.
At a meeting in Bethesda, Maryland, on June 17-18, experts in the fields of magnetic resonance imaging, functional imaging, neuropsychology, epidemiology, drug development, mild cognitive impairment (MCI), and Alzheimer’s disease gave brief presentations on these topics relevant to the development of a longitudinal, multi-center study of MCI, normal aging, and early Alzheimer’s disease. An advisory meeting of about twenty of these experts, including representatives from industry, followed to develop recommendations on how best to proceed. (Contacts: Drs. Susan Molchan or Neil Buckholtz, NNA, ph: 301-496-9350)
The Quantitative Reasoning in Adult Development and Aging workshop (exploratory) was held July 15-16, 2002. Comparatively little is known about this topic, although such skills are clearly required for accurate interpretation of medical and scientific news, wise investment and retirement decisions, and making sound judgments about health-related matters. Workshop participants possessed expertise across a wide range of relevant fields: numerical cognition, quantitative and document literacy, mathematics, judgment and decision-making, neuropsychology, and behavioral economics. The specific topics covered at the workshop included: age-related changes in numerical processing strategies, proportional and probabilistic reasoning processes, estimation skills, investment and risk-taking behaviors, and financial abilities in patients with Alzheimer’s disease. Based in part on the ideas and suggestions that emerged from this exploratory meeting, additional smaller meetings may be planned, and a program announcement may be issued. (Contacts: Dr. Daniel Berch, BSR, ph: 301-594-5942; Dr. Molly Wagster, NNA, ph: 301-496-9350)
Neurobiology of Aging and Alcohol Workshop. The NIA co-sponsored with the National Institute on Alcohol Abuse and Alcoholism (NIAAA) an exploratory workshop on the neurobiology of aging and alcohol, September 10-11, in Bethesda. The aging process is known to be associated with changes that place older individuals at special risk for alcohol-related health problems. Older and younger individuals differ in their metabolism of alcohol, as well as their physiological and behavioral responses to alcohol. One of the primary factors in heightened sensitivity is impaired development of alcohol tolerance. Drinking may also aggravate various pathological conditions in the elderly including stroke, hypertension, memory loss, and cognitive and emotional dysfunction. Although aging can be a key factor in the response to alcohol, the neurobiology underlying this relationship has remained largely unexplored. The goal of this workshop is to discuss basic neurobiological processes that may mediate alcohol-aging interactions. Recent progress in genetics, molecular biology, electrophysiology, pharmacology, neuroimaging, and behavior as they relate to aging and to effects of alcohol will be presented. (Contact: Dr. Molly Wagster, NNA, ph: 301-496-9350)
Alzheimer’s Prevention Trial Using a Statin Drug - Advisory Meeting As discussed at the last NIA retreat, there is reason to consider that statins may be useful for the prevention of Alzheimer’s disease, based on results from a Number of recent epidemiological studies as well as basic science considerations. However, there are biological, clinical, and methodological issues that need to be addressed before NIA can consider support of a prevention trial. To help delineate and clarify issues important to consider in the conception of such a trial, a Number of scientists with basic science, clinical, epidemiological, and intervention trial expertise on statins were invited to an advisory meeting held on September 12 in Bethesda, Maryland. (Contacts: Drs. Susan Molchan and Neil Buckholtz, NNA, ph: 301-496-9350)
The Extracellular Matrix and Aging Musculoskeletal System and Skin meeting (advisory) was held on September 16-17. This meeting was held to follow-up a small exploratory meeting on the musculoskeletal system and skin in the fall of 2001. Approximately 25 investigators in aging of skin, cartilage, bone and muscle were invited to participate. The meeting included presentations by participants on the latest information on changes in extracellular matrix in these four tissues with age, and how extracellular matrix affects the cells and tissue as a whole. In addition, small discussion groups formulated recommendations on future research areas for each tissue, and these groups met together to define recommendations with respect to cross-cutting issues in extracellular matrix biology and aging. This workshop will be the foundation for an initiative in extracellular matrix within the Musculoskeletal Biology program. A report of the meeting is being formulated for presentation at Council, along with the proposed initiative concept. (Contact: Dr. Jill Carrington, BAP, ph: 301- 496-6402).
Language and Aging Symposium— 1st symposium in the New Perspectives in Language Research Seminar Series. This inter-Institute exploratory symposium highlighted leading contemporary approaches to the study of human language. The meeting was held September 19 on the NIH campus, Bethesda, Maryland. The speakers presented new research on language changes with age and in age-related neurodegenerative diseases. Participants discussed the phenomenon of “elderspeak,” how language use in early life may predict later life outcomes, bilingualism and how it impacts cognitive change and language use in later life, and differences between normal age-related changes in language and those changes in relation to Alzheimer’s disease and Frontotemporal dementia (primary progressive aphasia). NIH sponsors were: NIA, the National Institute of Child Health and Human Development (NICHD), the National Institute on Deafness and Other Communication Disorders (NIDCD), the National Institute of Mental Health (NIMH), and the National Institute of Neurological Disorders and Stroke (NINDS). (Contact: Dr. Molly Wagster, NNA, ph: 301- 496-9350)
Cellular and Molecular Biology of Cognitive Aging. The NNA Program will sponsor this exploratory symposium November 5 in Orlando, Florida, during the meeting of the Society for Neuroscience. The symposium format will include the following: a brief overview of cognitive change with age and the current approaches being used to examine the bases of this change at the cellular and molecular levels; the effects of aging on structural plasticity in the hippocampal system, evidence for oxidative stress in aged hippocampal neurons and its relationship to cognitive decline, and recent efforts to assess hippocampal neurogenesis and cognitive status during aging; the relationship of learning ability in aging animals to postsynaptic excitability of hippocampal neurons, and alterations in slow outward potassium currents and their contribution to impaired learning ability with age; the calcium dysregulation hypothesis of brain aging and cognitive decline and use of gene expression profiling in brain aging research; the impact of altered ion channel function in transgenic animals including the impact of a potassium channel subunit deletion on neuronal firing and behavior, and use of a mouse model that mimics up-regulation of L-type calcium channel expression. (Contact: Dr. Molly Wagster, NNA, ph: 301-496-9350)
Methodologic Issues for Non-Pharmacologic Interventions in Dementia. The Neuroscience and Neuropsychology of Aging Program will co-sponsor a one-day exploratory meeting in November 2002 in Bethesda, Maryland, on non-pharmacologic interventions in dementia, with the American Association for Geriatric Psychiatry and in conjunction with the National Institute of Mental Health, the National Institute of Nursing Research, and the Alzheimer’s Association. The objective of this workshop is to foster a round-table discussion with experts in the field to better understand the barriers in non-pharmacologic intervention research. Specifically participants will:
The Proteomics and Aging Workshop (advisory) is scheduled to be held November 18-19, 2002. The purpose of the workshop is to discuss the potential applications of new high throughput technologies in proteomics to aging research. The workshop will aim at facilitating interactions between researchers well established in the field of proteomics, with those well established in the field of aging. Development of a strategy to recruit protein chemists with experience in proteomics to the aging field is expected, and recommendations from the workshop are expected to lead NIA staff to develop the guidelines for a future RFA on the subject. (Contacts: Dr. Felipe Sierra, BAP, ph: 301-496-6402; Dr. Bradley Wise, NNA, ph: 301-496-9350)
The Biology of Aging Kidney Workshop will be held on January 23-24, 2003 in the Washington, DC area. The purpose of this exploratory workshop is to review the current state of research regarding age-related changes in kidney function, and to discuss important and specific gaps in knowledge. Areas to be covered include: epidemiology, human longitudinal studies, kidney physiology, stem cells in the kidney, age changes in kidney biology and physiology. Also, a Number of speakers addressing biology of aging issues relevant to the biology of aging kidney will be included, such as cell senescence, telomeres/telomerase, kidney function and pathology in animal models of increased longevity, age-changes in kidney pathology, oxidative damage, and protein glycation. (Contact: Dr. Frank Bellino, BAP, ph: 301-496-6402)
Mr. Mike Lockard retired after a 19-year career at NIA. His last position was as Chief, Administrative Branch, in the Office of Administrative Management. In retirement, Mr. Lockard plans to do consulting and contracting work and help coach high school football.
Ms. Celena Shirley, who began her career at NIA as a clerical assistant in 1992 and advanced to become an Administrative Officer, will leave the Institute in September for a position as Senior Administrative Officer for NIAID/Extramural Administrative Branch/Division of Extramural Activities.
Dr. Dwight Brock retired March 31, after over 30 years Federal Government service to take a position at Westat, Inc. as a senior survey statistician. He was Chief of the Biometry Section, Laboratory of Epidemiology, Demography, and Biometry.
Dr. Brock’s interest in statistical methodology focused on the use of longitudinal data, including improved analytic methods for analysis of repeated observations from longitudinal studies in the Established Populations for the Epidemiological Studies of the Elderly (EPESE) and the Women’s Health and Aging Study (WHAS). Recently his research focused on statistical imputation methods for improving estimates of the incidence of dementia in the Honolulu-Asia Aging Study (HAAS). Also, he assisted in the design of the Healthy Aging in Nationally Diverse Longitudinal Samples (HANDLS) study to extend it from a convenience sample to a population-based cohort study representative of the population living in Baltimore City.
Dr. Steven J. Sollott received tenure in NIA’s Intramural Research Program in the Laboratory of Cardiovascular Science. The major focus of Dr. Sollott’s research involves the hypothesis that specific local control mechanisms of nitric oxide (NO) and reactive oxygen species (ROS) production are responsible for important aspects of their physiologic and/or pathological roles. This led to the discovery of new, endogenous signaling paradigms for both ROS and NO that regulate fundamental functional properties and mechanisms in cardiac myocytes. Through these studies he developed new techniques to exploit interactive optical methodologies in live cells with spatial and temporal resolution at the physical limits imposed by laser light as well as that by technology. Another of Dr. Sollott’s findings relates to the fact that paclitaxel (Taxol), a drug used to treat cancer, could markedly attenuate vascular restenosis following angioplasty (Sollott et al., J Clin Invest 1995; 95(4): 1869-1876). Findings from paclitaxel-coated stent anti-restenosis clinical trials indicate that paclitaxel may prevent human restenosis without adverse effects.
Dr. John Kusiak, who has been with NIA’s Intramural Research Program for twenty years, has joined the Research Resources Branch (RRB) as the Deputy Chief. In his new role, he will supervise RRB’s scientific services provided by the Central Laboratory Services Section (CLSS) and the Comparative Medicine Section. Dr. Kusiak succeeds Dr. Dennis Taub as Section Chief of the CLSS. Dr. Taub will return to his full-time duties as the Acting Chief of the Laboratory of Immunology.
Dr. Michael-David ARR Kerns, MBA, MS, PhD, has joined the Office of Extramural Affairs as a Health Scientist Program Specialist to assume responsibility for Small Business programs and to assist with training activities. Dr. Kerns is trained as a Lifespan Developmental Psychologist, with a special emphasis on adult development and aging. He also has a concentration in Statistics, particularly in modeling techniques. Dr. Kerns completed post-doctoral fellowships at the German Centre for Research on Ageing at the University of Heidelberg with Peter Martin and at the Center for the Studies of Ethnicity and Human Development at Long Island University with Carol Magai.
Following completion of his post-doctoral fellowships, Dr. Kerns worked with two private research companies on several funded SBIR grant applications.
Dr. Alfonso R. Latoni, PhD, joined the Scientific Review Office on May 19, 2002, as a Health Scientist Administrator. Prior to joining the National Institute on Aging, Dr. Latoni was Director of the Minority Affairs Program of the American Sociological Association (ASA) in Washington, DC, and Program Director of ASA’s Minority Fellowship Program (MFP). Prior to that, he was Associate Professor of Sociology and Applied Social Research at the Universidad de Puerto Rico, Recinto Universitario de Mayagüez. Over the past decade, Dr. Latoni has focused his research on issues of social, demographic, and economic inequalities among underrepresented populations in Puerto Rico and Latin America, with particular emphasis to the underclass, the elderly, and the homeless.
Mr. Kevin Crist, who was employed in NIA’s Grants and Contracts Management Office as a Grants Technical Assistant 11 years ago, has returned to NIA as a Grants Management Specialist. Mr. Crist is coming to us from the National Institute of Dental Research where he worked as a Grants Management Specialist.
Ms. Carol Lander, who served in the NIA for 24 years as a Grants Technical Assistant, Office Manager, and as a Grants Management Specialist for the last three years, has accepted a position at the National Heart, Lung, and Blood Institute (NHLBI) as a Grants Management Specialist.
Ms. Vicki Maurer, who was NIA’s Deputy Grants Management Officer, also accepted a position at NHLBI as a Grants Management Specialist.
Ms. Georgeanne Patmios, of the Behavioral and Social Research Program, received an individual NIH Merit Award at the NIH OD Honor Award Ceremony on August 14 for her work in the NIH Office of Behavioral and Social Sciences Research.
Dr. Miriam Kelty, Associate Director for Extramural Affairs, received an NIH Merit Award for revising NIH policies and procedures for monitoring inclusion of women and minorities in research and for facilitating gender analysis.
The NIA/Behavioral and Social Research Program’s Resource CD-ROM Created in July 2002, Version 2.0 of the Behavioral and Social Research (BSR) Resource CD-ROM contains general history and plans of the Behavioral and Social Research Program as well as abstracts of applications that were funded by the Program in fiscal year 2001 and reports from BSR-sponsored workshops. In a section on “resources for researchers,” there is information about available datasets and data warehouses with aging-related information (e.g., BSR Publicly Available Datasets and information about the National Center for Health Statistics’ Electronic Data Warehouse). The CD-ROM includes an extensive collection of literature, including a complete set of Research Highlights in the Demography and Economics of Aging, NIA works such as Diverse Voices, a report on non-English speakers in surveys, and the 1999 Progress Report on Alzheimer’s Disease. The collection of literature also includes the Census Bureau’s 65+ and Aging World 2001. This version of the BSR resource CD-ROM includes the complete set of Books on Aging and Health by the U.S. National Academies (see below).
An updated CD-ROM entitled “Books on Aging and Health by the U.S. National Academies” This resource was first issued in the fall of 2001, and has been regularly updated by the National Research Council, Committee on Population for the National Institute on Aging. The CD-ROM contains the complete contents of 13 books/reports funded (in whole or part) by the NIA and published by the National Academy Press during the 1990s and early 2000s. It includes: The Aging Mind: Opportunities in Cognitive Research; Assessing Knowledge of Retirement Research; Assessing Policies for Retirement Income: Needs for Data, Research and Models; Between Zeus and the Salmon: The Biodemography of Longevity; Cells and Surveys: Should Biological Measures Be Included in Social Science Research? Demography of Aging; Forecasting Survival, Health, and Disability (Summary of a Workshop); Improving Access to and Confidentiality of Research Data (Report of a Workshop); Improving Data on America’s Aging Population (Summary of a Workshop); New Horizons in Health: An Integrative Approach; Preparing for an Aging World: The Case for Cross-National Research; Racial and Ethnic Differences in the Health of Older Americans; and Trends in Disability at Older Ages (Summary of a Workshop).
United Nations, Department of Economic and Social Affairs, Population Division, (New York, 2002). World Population Ageing: 1950-2050. This report was prepared by the Population Division as a contribution to the 2002 World Assembly on Aging and its follow-up. The report provides a description of global trends in population aging and includes a series of indicators of the aging process by development regions, major areas, regions and countries. Partial financial support for this publication was provided by the National Institute on Aging and by the Bureau of the Census.
World Health Organization. (Geneva, 2002) Summary Measures of Population Health: Concepts, Ethics, Measurement and Applications. Edited by Christopher JL Murray, Joshua A. Salomon, Colin D. Mathers and Alan D. Lopez. This volume addresses the conceptual, ethical, empirical and technical challenges in summarizing the health of populations. This is critical for monitoring whether levels of population health have improved over time and for understanding why health differs across settings. At the same time, it is also important to recognize that improving population health is not the only goal of health policy and to understand the way health improvements interact with these other goals. For that reason, this volume also briefly reviews the WHO framework for assessing the performance of health systems and the role of summary measures of population health in this framework.
NIH Senior Health.gov On March 19, the new senior-friendly web site, NIH Senior Health.gov, was opened for beta-testing. The web site is the result of a two-year collaborative effort between NIA’s Office of Communications and Public Liaison (OCPL) and the National Library of Medicine (NLM). The web site’s researched-based design has been tailored to meet the cognitive and visual requirements of adults 60 and older. Currently, the site offers information on three aging-related health topics: Alzheimer’s Disease, Caring for Someone with Alzheimer’s Disease, and Exercise for Older Adults. More topics are planned. Focus group and usability testing has been conducted nationwide. Additional topics are being prepared and will be added to the site in the fall, after which the site will be officially launched.
The following Age Page topics, newly translated into Spanish, are available: Arthritis; Constipation; High Blood Pressure; Prostate Problems.
Guide for Caregivers of People with Alzheimer’s Disease has been translated into Spanish, Guia Para Quienes Cuidan Personas con la Enfermedad de Alzheimer’s offers suggestions on 17 topics of concern and support for both the caregiver and the person with Alzheimer’s disease. A list of national resource organizations is included.
Alzheimer’s Disease Fact Sheet, has been translated into Spanish, La enfermedad de Alzheimer, provides basic information about symptoms, diagnosis, approved and potential treatments being researched, and sources of help for caregivers.
Multi-Infarct Dementia Fact Sheet (revised) – This update on multi-infarct dementia (MID) incorporates recent research relating untreated high blood pressure, high cholesterol, and smoking to vascular dementia, and recommends diagnostic tests, stroke prevention, and ways to help someone with MID and their caregiver.
Home Safety for the Person with Alzheimer’s Disease (updated) – This popular booklet, originally produced by the University of California San Diego Alzheimer’s Disease Center and sold through the ADEAR Center cost-recovery program, has been updated and reprinted, and is now offered as a free publication.
Connections Reprint – Two articles on frontotemporal dementia (FTD) from the Summer 2002 issue summarize similar and differing features of Alzheimer’s disease and FTD, and clinical characteristics of selected FTDs (Pick’s disease, FTDP-17, supranuclear palsy, and corticobasal degeneration).
(For more information on these publications contact: Jane E. Shure, Director, OCPL, ph: 301-496-1752.)
From the NIH GUIDE - From April 26, 2002 – September 4, 2002Published since the last National Advisory Council on Aging Meeting.Also check our NIA website “Current Funding Opportunities”(Shown here are selected Notices relevant to NIA and selected Initiatives)
Change in Receipt Date for Centers for Population Health and Health Disparities (RFA ES-02-009)Release Date: August 30, 2002 (also see RFA ES-02-009) Notice: NOT-ES-02-012http://grants2.nih.gov/grants/guide/Notice-files/NOT-ES-02-012.htmlNational Institute of Environmental Health Sciences (NIEHS) (http://www.niehs.nih.gov/), National Cancer Institute (NCI) (http://cancer.gov/), National Institute on Aging (NIA) (http://www.nia.nih.gov/), and the Office of Behavioral and Social Sciences Research (OBSSR) (http://obssr.od.nih.gov/).This Notice changes the application receipt date for RFA ES-02-009. Applications should be received in CSR (and two copies to NIEHS) by Friday, September 6, 2002.
Non-Competing Grant Progress Report Due Date Information —OER Website Now AvailableRelease Date: August 13, 2002Notice: NOT-OD-02-066http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-02-066.htmlNational Institutes of Health (NIH) NIHcontinues to transition the notification of Non-Competing Grant Progress Reports from a hard copy mailing of preprinted electronic PHS 2590 and PHS 416-9 face pages to an electronic format.
Correction of Web Address for The Informational Website or the RFA on Centers for Population Health and Health Disparities Release Date: July 24, 2002Notice: NOT-CA-02-022http://grants1.nih.gov/grants/guide/Notice-files/NOT-CA-02-022.html National Institute of Environmental Health Sciences (NIEHS) (http://www.niehs.nih.gov/), National Cancer Institute (NCI) (http://www.cancer.gov/), National Institute on Aging (NIA) (http://www.nia.nih.gov/). Please note that an earlier Guide Notice, NOT-ES-02-010, released May 28, 2002, regarding RFA-ES-02-009, "Centers for Population Health and Health Disparities" gave an erroneous address for the RFA informational website. The correct address is http://cancercontrol.cancer.gov/populationhealthcenters.
PHS Policy on Humane Care and Use of Laboratory Animals Clarification Regarding Use of Carbon Dioxide for Euthanasia of Small Laboratory AnimalsRelease Date: July 17, 2002Notice: (NOT-OD-02-062)http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-02-062.htmlNational Institutes of HealthThe Office of Laboratory Animal Welfare (OLAW) has determined a need to issue Public Health Service Policy on Humane Care and Use of Laboratory Animals (PHS Policy) guidance to Assured institutions clarifying current requirements regarding the use of carbon dioxide (CO2) as a euthanasia agent for small laboratory animals.
Update of the PHS 2590 and PHS 398 Instructions Release Date: July 2, 2002Notice: NOT-OD-02-059http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-02-059.htmlNational Institutes of HealthApplicants are urged to discard previous versions of the PHS 398 and PHS 2590 instructions and use the current versions to ensure they have the most accurate information. This Notice is an addendum to several Notices in the NIH Guide for Grants and Contracts.
NIH Expands to Six-Digit Application NumbersRelease Date: June 24, 2002Notice: NOT-OD-02-056http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-02-056.htmlNational Institutes of HealthThe growth of NIH funding has resulted in record Numbers of grant applications and awards. The National Cancer Institute (NCI) reached a milestone in June with the assignment of application Number CA99999. The next Number assigned to NCI was the first at NIH to use 6 digits in its serial Number. Application Numbers are assigned sequentially within NIH Institutes and Centers. We do not anticipate other Institutes or Centers will reach six digits before FY2003.
Procedures for Submission of Compliance Documents to the Human Pluripotent Stem Cell Review Group for the Research Use of Human Embryonic Germ Cells Release Date: May 3, 2002Notice: NOT-OD-02-049http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-02-049.htmlNational Institutes of HealthResearch use of human embryonic germ cells derived from fetal tissue with Federal funds requires review of compliance with the NIH Guidelines for Research Using Human Pluripotent Stem Cells http://www.nih.gov/news/stemcell/stemcellguidelines.htm. Embryonic germ cells are pluripotent stem cells derived from fetal tissue and are distinct from human embryonic stem cells that are derived from human embryos. This Notice does not pertain to human embryonic stem cells. The Guidelines require that certain documents be submitted to and reviewed by the Human Pluripotent Stem Cell Review Group (HPSCRG).
Update on the Transition to Electronic Non-Competing Grant Progress Report Notification Release Date: May 2, 2002Notice: NOT-OD-02-047http://grants1.nih.gov/grants/guide/Notice-files/NOT-OD-02-047.htmlNational Institutes of Health (NIH)This notification is an update to the July 10, 2001 NIH Guide Notice. NIH continues to transition the notification of Non-Competing Grant Progress Reports from a hard copy mailing of preprinted electronic PHS 2590 and PHS 416 face pages to an electronic notification. To facilitate this transition, NIH will continue mailing pre-printed type 5 face pages for awards with start dates through November 2002. November provides a two-month extension from the previously announced cessation date to allow grantees and NIH staff time to transition to the new business practices. NIH will make information on due dates for Non-Competing Grant Progress Reports accessible electronically in two ways:
Starting in August 2002, the NIH Office of Extramural Research will host a public website of Non-competing Progress Report due date information that will have search and sort capabilities. Grantees may choose to use this website until they register for the NIH Commons. Users of this website will not receive reminders electronically or have pre-printed face pages available.
Upon registration for the NIH Commons, institutional officials will have the opportunity to establish a central e-mail address for notification of NIH pending actions and general NIH Commons activities. By this means the institution will receive a list of pending non-competing progress reports. We expect registration for the NIH Commons to begin in August 2002.
Long-Term Care Recipients: Quality of Life and Quality of Care Research (R01, R21)Release Date: September 4, 2002Program Participating: Behavioral and Social Research (BSR) ProgramPA Number: PA-02-162http://grants2.nih.gov/grants/guide/pa-files/PA-02-162.htmlApplication Receipt Dates: November 19, 2002, 2003, 2004Purpose of This PAThe purpose of this program announcement is to encourage research on improving the quality of life, health, functional abilities, and health outcomes for residents of long-term care (LTC) institutions such as nursing homes, extended care, and assisted living facilities. Impaired quality of life, poor functional status, and health concerns are well documented in LTC settings to have a deleterious impact on outcomes. Research is also needed for understudied age groups, ethnic groups, and for certain health conditions.Direct your questions about scientific/research issues to:Dr. Sidney M. StahlChief, Behavioral MedicineNational Institute on Aging7201 Wisconsin Ave., #533Bethesda, MD 20892-9205Telephone: (301) 402-4156FAX: (301) 402-0051Email: Sidney_Stahl@nih.gov
Novel Approaches to Enhance Animal Stem Cell Research (R01, R21)Release Date: August 9, 2002Program Participating: Biology of Aging ProgramPA Number: PA-02-147http://grants1.nih.gov/grants/guide/pa-files/PA-02-147.htmlApplication Receipt Dates: November 19, 2002, 2003, 2004Purpose of This PAThepurpose of this program announcement (PA) is to encourage the submission of applications for research to enhance animal stem cells as model biological systems.Direct your questions about scientific/research issues to:Jill L. Carrington, Ph.D.Biology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 2C231Bethesda, MD 20892-9205Telephone: (301) 496-6402FAX: (301) 402-0010Email: carringtonj@nia.nih.gov
Tools for Genetic Studies in Zebrafish (R01)Release Date: August 2, 2002Program Participating: Biology of Aging ProgramPA Number: PAR-02-142http://grants1.nih.gov/grants/guide/pa-files/PAR-02-142.htmlApplication Receipt Dates: November 19, 2002, 2003, 2004Purpose of This PAThisProgram Announcement (PA) is to encourage investigator-initiated applications for research designed to exploit the power of mutagenesis screening in zebrafish in order to detect and characterize genes, pathways, and phenotypes of interest in development and aging, organ formation, behavior, and disease processes. Applications that propose to advance the technologies associated with such phenotyping also are welcome.Direct your questions about scientific/research issues to:Nancy L. Nadon, Ph. D.Head, Office of Biological Resources and Resource DevelopmentNational Institute on AgingGW 2C231, MSC 92057201 Wisconsin Ave.Bethesda MD 20892Telephone: (301) 402-7744FAX: (301) 402-5997Email: nadonn@nia.nih.gov
Precursor Cells in Skeletal Muscle Repair and Hypertrophy (R01)Release Date: July 25, 2002Program Participating: Biology of Aging ProgramPA Number: PA-02-136http://grants1.nih.gov/grants/guide/pa-files/PA-02-136.htmlApplication Receipt Date: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PAApplicationsare being sought to isolate, characterize and identify precursor cells required for normal growth and repair of injured, aged, or diseased muscle. Goals include determining factors responsible for migration, proliferation, and differentiation of precursor cells following muscle injury or increased exercise. This includes characterizing molecular controls responsible for the quiescence of muscle satellite cells and determining metabolic and motile properties of satellite cells while they are quiescent.Direct your questions about scientific/research issues to:Jill L. Carrington, Ph.D.Musculoskeletal Biology Biology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue Suite 2C231Bethesda, MD 20892Telephone:(301) 496-6402FAX: (301) 402-0010Email: carringtonj@nia.nih.gov
Age-Related Changes in Tissue Function: Underlying Biological Mechanisms (R01)Release Date: July 12, 2002Program Participating: Biology of Aging ProgramPA Number: PA-02-128http://grants1.nih.gov/grants/guide/pa-files/PA-02-128.htmlApplication Receipt Date: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PA Thisprogram announcement is to solicit applications on biological mechanisms of aging in tissues and organs. Projects are encouraged that significantly advance basic biology research to understand how and why changes take place in tissues with age and how those changes relate to altered tissue and organ function. Projects that focus on molecular aspects, as well as cellular aspects of tissue aging, are encouraged.Direct your questions about scientific/research issues to:Frank L. Bellino, Ph.D.Endocrinology PhysiologyNational Institute on Aging7201 Wisconsin Avenue, Suite 2C231 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-6402FAX: (301) 402-0010Email: bellinof@nia.nih.govJill L. Carrington, Ph.D.Chief, Systems Branch, Biology of Aging ProgramMusculoskeletal BiologyNational Institute on Aging7201 Wisconsin Avenue, Suite 2C231 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-6402FAX: (301) 402-0010 Email: carringtonj@nia.nih.govDavid B. Finkelstein, Ph.D.Cardiovascular BiologyNational Institute on Aging7201 Wisconsin Avenue, Suite 2C231 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-6402FAX: (301) 402-0010Email: finkelsd@nia.nih.govRebecca A. Fuldner, Ph.D.ImmunologyNational Institute on Aging7201 Wisconsin Avenue, Suite 2C231 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-6402FAX: (301) 402-0010Email: fuldnerr@nia.nih.govStanley Slater, M.D.Geriatrics and Clinical Gerontology ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 3E327Bethesda, MD 20892-9205Telephone: (301) 496-6761FAX: (301) 402-1784Email: slaters@nia.nih.govBradley C. Wise, Ph.D.Neuroscience and Neuropsychology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 3C307 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-9350FAX: (301) 496-1494Email: wiseb@nia.nih.gov
Mentored Quantitative Research Career Development Award (K25) (supercedes PA-99-087)Release Date: July 10, 2002Program Participating: All four of NIA’s Extramural Program AreasPA Number: PA-02-127http://grants1.nih.gov/grants/guide/pa-files/PA-02-127.htmlApplication Receipt Date: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PA Thisinitiative invites applications for the K25 mechanism which is meant to attract to NIH-relevant research those investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. Examples of quantitative scientific and technical backgrounds considered appropriate for this award include, but are not limited to: mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry, and engineering.Direct your questions about scientific/research issues to:Robin Barr, Ph.D.Office of Extramural AffairsNational Institute on AgingGateway Building, Room 2C2187201 Wisconsin Avenue, MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-9322FAX: (301) 402-2945Email: rb42h@nih.gov
Bioengineering Nanotechnology Initiative (R44) (supercedes PA-00-018)Release Date: July 2, 2002 (see also PA-00-018)Program Participating: PA Number: PA-02-125http://grants1.nih.gov/grants/guide/pa-files/PA-02-125.htmlApplication Receipt Date: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PAThis Program Announcement (PA), issued as an initiative of the trans-NIH Bioengineering Consortium (BECON), invites grant applications for Small Business Innovation Research (SBIR) projects on nanotechnologies useful to biomedicine.Direct your questions about scientific/research issues to:Winifred K. Rossi, M.A.;Geriatrics and Clinical Gerontology ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 3E327Bethesda, Maryland 20892-9205Telephone: (301) 496-3836Fax: (301) 402-1784Email: wr33a@nih.gov
Age-Related Prostate Growth: Biologic Mechanisms (R01 and R21)Release Date: June 25, 2002Program Participating: Biology of Aging ProgramPA Number: PA-02-116http://grants1.nih.gov/grants/guide/pa-files/PA-02-116.htmlApplication Receipt Date: Standard NIH Receipt DatesPurpose of This PA Substantial data currently exist showing that prostate volume increases with age in middle-aged and older men, following a post-pubertal plateau. In addition, the incidence and prevalence of prostate disease increase with age, and are very high in elderly men. This initiative invite research applications addressing biologic mechanisms related to aging processes that underlie the initiation and progression of prostate growth processes in middle-age, and the pathophysiologic connections of that growth process with the prostate diseases prevalent in older men, benign prostatic hypertrophy (BPH) and prostate cancer.Direct your questions about scientific/research issues to:Frank Bellino, PhDBiology of Aging Program National Institute on Aging Gateway Building, Suite 2C231Bethesda, MD 20892-9205Telephone: (301) 496-6402FAX: (301) 402-0010Email: bellinof@nia.nih.gov
Genetic Architecture, Biological Variation, and Complex Phenotypes (R01)Release Date: May 29, 2002Program Participating: Geriatrics and Clinical Gerontology ProgramPA Number: PA-02-110http://grants1.nih.gov/grants/guide/pa-files/PA-02-110.htmlApplication Receipt Date: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PAThis announcement invites applications for new studies on genetic variation and the architecture of complex phenotypes. It restates the interest of several components of the National Institutes of Health in studies of the underlying causes and architecture of complex phenotypes, including human diseases.Direct your questions about scientific/research issues to:Winifred K. Rossi, M.A.Geriatrics and Clinical Gerontology ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 3E327Bethesda, Maryland 20892-9205Telephone: (301) 496-3836Fax: (301) 402-1784Email: wr33a@nih.gov
NIH National Research Service Award Institutional Research Training Grants (T32)Release Date: May 16, 2002Program Participating: All four of NIA’s Extramural Program AreasNote: This program announcement supercedes the Notice that appeared in the NIH Guide on June 1, 2000 as PA-00-103. PA Number: PA-02-109http://grants1.nih.gov/grants/guide/pa-files/PA-02-109.htmlApplication Receipt Date: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of the PAThe purpose of the NRSA program is to help ensure that a diverse and highly trained workforce is available to assume leadership roles related to the Nation's biomedical and behavioral research agenda. Accordingly, the NRSA program supports predoctoral, postdoctoral, and short-term research training experiences.For information concerning the areas of research, receipt dates, and other types of pre-application instructions:Robin Barr, Ph.D.Office of Extramural AffairsNational Institute on AgingGateway Building, Room 2C2187201 Wisconsin Avenue, MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-9322FAX: (301) 402-2945Email: rb42h@nih.gov
Basic and Translational Research on the Cognitive Sequelae of Parkinson's Disease (R01)Release Date: May 8, 2002Program Participating: Neuroscience and Neuropsychology of Aging ProgramPA Number: PAS-02-107http://grants1.nih.gov/grants/guide/pa-files/PAS-02-107.htmlApplication Receipt Date: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PAThis announcement invites research grant applications (R01) that address the underlying neurobiological mechanisms associated with the cognitive and linguistic sequelae of Parkinson's disease. A major goal of this PA is to begin a process where basic and clinical scientists from various disciplines can overcome barriers to cross-disciplinary research and examine all aspects of cognition in the context of the diagnosis and treatment of Parkinson's disease.Direct your questions about scientific/research issues to:Judith A. Finkelstein, Ph.D.Neuroscience and Neuropsychology of Aging National Institute on AgingGateway Building, Suite 3C3077201 Wisconsin AvenueBethesda MD 20892-9205 (Express Zip 20814)Telephone: (301) 496-9350 FAX: (301) 496-1494Email: jf119k@nih.gov
Coordinating Center for Calerie (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy) Studies (U01)Release Date: May 8, 2002Program Participating: Geriatrics and Clinical Gerontology ProgramRFA: AG-02-007http://grants1.nih.gov/grants/guide/rfa-files/RFA-AG-02-007.htmlApplication Receipt Date: July 12, 2002Purpose of This RFAThis announcement invites applications for a Cooperative Agreement (UO1) to establish a Coordinating Center (CC) for the CALERIE (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy) studies. The three recently funded CALERIE sites (also UO1 studies) are exploratory controlled studies on the effects of sustained caloric restriction interventions on physiology, body composition, and risk factors for age-related pathologies in non-obese persons.Direct inquiries regarding programmatic issues to:Charles Hollingsworth, Dr. P.H.Branch Chief, Clinical Trials BranchGeriatrics and Clinical Gerontology ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 3E-327 MSC 9205Bethesda, MD 20892-9205Express Mail Zip Code: 20814Telephone: 301/435-3047;FAX: 301/402-1784E-mail: hollinc@nia.nih.gov
Research on Ethical Issues in Human Studies (R01)Release Date: May 1, 2002Program Participating: Neuroscience and Neuropsychology of Aging ProgramPA Number: PA-02-103http://grants1.nih.gov/grants/guide/pa-files/PA-02-103.htmlApplication Receipt Date: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PA This PA replaces PA-99-079. This application invites research grant applications (R01) to investigate ethical issues in human subjects research. The Code of Federal Regulations - Protection of Human Subjects (45 CFR, Part 46) provides a regulatory framework that all NIH-supported researchers must follow. Recent developments in biomedical and behavioral research, however, including the rapid growth of new interventions and technologies (e.g., stem cells, genetics research), increasing involvement of foreign populations in clinical research, and concerns about financial conflicts of interest among researchers, challenge investigators' abilities to interpret and apply the regulations.Direct your questions about scientific/research issues to:Elisabeth Koss, Ph.D.Neuroscience and Neuropsychology of Aging ProgramNational Institute on AgingGateway Building, Suite 3C3077201 Wisconsin Ave MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-9350FAX:(301) 496-1494E-mail: kosse@nia.nih.gov
Complex Formation in Hormonal Regulation of Gene Expression (R01 and R21)Release Date: April 26, 2002Program Participating: Biology of Aging ProgramPA Number: PA-02-100http://grants1.nih.gov/grants/guide/pa-files/PA-02-100.htmlApplication Receipt Date: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of This PAThis initiative represents a reissue of PA99-111 (Coactivators and Corepressors in Gene Expression). The original PA was based on an NIDDK Workshop ("Co-Activators and Co-Repressors in Gene Expression," December 15-16, 1998) and was designed to stimulate research to address the fundamental underlying mechanisms by which nuclear accessory proteins, such as coactivators and corepressors, mediate signaling through hormone receptors at the level of the regulation of gene expression. The reissued PA seeks to exploit and expand upon advances made since then in this, and other related areas and refine the role of higher order complex formation in effecting hormonal regulation of gene expression.Direct your questions about scientific/research issues relevant to NIA to:Frank Bellino, Ph.D.Endocrinology Program AdministratorDeputy Associate DirectorBiology of Aging ProgramNational Institute on AgingGateway Bldg., Suite 2C231Bethesda, MD 20892-9205Telephone: 301 496-6402FAX: 301 402-0010E-mail: fb12a@nih.gov
As presented in the FY 2003 Congretional JustificationDate: 07/29/02
| Disclaimer | Accessibility | Policies | Contact Us | FOIA | Site Map
