Current Centers
Past Centers
Current Centers
Center for Cell Decision Processes
Principal investigator: Peter Sorger, Ph.D., Massachusetts Institute of Technology
The Center for Cell Decision Processes focuses on developing numerical models of the mammalian signal transduction networks that regulate cell death and proliferation and on testing these models experimentally. Since all the models are built using empirical data, a significant effort is devoted to systematizing and automating biological measurements.
Web site: http://www.cdpcenter.org/
Center for Cell Dynamics
Principal investigator: Garrett M. Odell, Ph.D., University of Washington Friday Harbor Laboratories
The Center for Cell Dynamics focuses both on high-resolution imaging methods for visualizing molecular interactions and on building computer simulations that capture systems-level properties of pattern formation, cytoskeleton dynamics, and cell cycle regulation in worms, flies, and marine invertebrates.
Web site: http://raven.zoology.washington.edu/celldynamics/
Center for Complex Biological Systems
Principal investigator: Arthur Lander, M.D., Ph.D, University of California, Irvine
The Center for Complex Biological Systems focuses on how biological systems in model organisms process spatial information during development, intracellular signaling, and cell proliferation. Other efforts include the development of computational and optical tools needed for measuring and modeling spatially dynamic systems.
Web site: http://ccbs.bio.uci.edu/
Center for Genome Dynamics at the Jackson Laboratory
Principal investigator: Gary Churchill, Ph.D., Jackson Laboratory
The Center for Genome Dynamics at the Jackson Laboratory focuses on how patterns of genetic variation emerge and persist over time. By creating a collection of genetic information from a set of more than 200 inbred strains of mice, the research team studies expression patterns to identify co-expressed genes, examine how these patterns evolved, and investigate how the overall genome organization affects phenotype.
Web site: http://www.genomedynamics.org/
Center for Modular Biology
Principal investigator: Andrew Murray, Ph.D., Harvard University
The Center for Modular Biology investigates how well the idea of “functional modules” (sets of molecules) helps us understand the organization, behavior, and evolution of cells and organisms. Combining computational and experimental approaches, the center studies how modules allow long-term evolvability to coexist with short-term robustness, asks how modules affect interactions among mutations in evolution, and examines the role of modules in the interplay between social behavior and gene expression.
Web site: http://www.sysbio.harvard.edu/csb/about/index.html
Center for Quantitative Biology
Principal investigator: David Botstein, Ph.D., Princeton University
The Center for Quantitative Biology uses advanced computational methods to understand how biological molecules interact with and respond to their environment. The center facilitates systems biology research by providing its participants and other Princeton labs access to state-of-the-art-technologies for computation, DNA microarray, advanced imaging, and mass spectrometry. Education at the undergraduate and graduate level is a key activity.
Web site: http://quantbio.princeton.edu/
Center for Systems Biology
Principal investigator: Leroy Hood, M.D., Ph.D., Institute for Systems Biology
The Center for Systems Biology is designing and developing novel tools for microfluidic measurement, molecular imaging, and computational modeling to better understand how cells differentiate and respond to environmental changes, to identify diagnostic markers of prostate cancer, and to model cell dynamics and signaling networks.
Web site: http://www.centerforsystemsbiology.org/
Chicago Center for Systems Biology
Principal Investigator: Kevin White, Ph.D., University of Chicago
The Chicago Center for Systems Biology will focus on modeling the dynamic behavior of transcriptional regulatory networks as they respond to physiological, developmental, and evolutionary inputs and pressures. The research in the center is expected to reveal structure-function relationships in networks that lead to robustness of cells and organisms in response to environmental and genetic change.
Web site: http://www.igsb.org
Duke Center for Systems Biology
Principal investigator: Philip Benfey, Ph.D., Duke University
The Duke Center for Systems Biology employs a systems biology approach to address the orchestrated processes of the cell cycle, development and differentiation, and population variation in model organisms.
Web site: http://www.genome.duke.edu/centers/csb/
New York Center for Systems Biology
Principal investigator: Ravi Iyengar, Ph.D., Mount Sinai School of Medicine
The New York Center for Systems Biology focuses on the systems-level study of medicine and therapeutics. The team integrates theoretical and experimental approaches to understand how drugs—both therapeutic and abused—affect the organization and physiology of cells, tissues, and organs. The researchers will concentrate on interactions occurring in the heart and brain.
Web site: http://www.sbcny.org/
Past Centers
Center for Modeling Integrated Metabolic Systems
Principal investigator: Gerald M. Saidel, Ph.D., Case Western Reserve University
The Center for Modeling Integrated Metabolic Systems focused on quantifying relationships between cellular metabolism and physiological responses of tissue-organ systems and the whole body. Primary emphasis was on cellular metabolism in skeletal muscle, the brain, the heart, and the liver to evaluate metabolic pathways and regulatory mechanisms under normal and abnormal states.
Web site: http://www.csuohio.edu/mims/contact.htm
