CAS numbers: 95��(o璱somer), 108�� (m璱somer), 106��(p璱somer)
NIOSH REL: 2.3 ppm (10 mg/m3) TWA
Current OSHA PEL: 5 ppm (22 mg/m3) TWA [skin]
1989 OSHA PEL: Same as current PEL
1993�94 ACGIH TLV: 5 ppm (22 mg/m3) TWA [skin]
Description of Substance: White crystals with a sweet, tarry odor.
LEL(@300 F): 1.4% (10% LEL(@300 F), 1,400 ppm)
Original (SCP) IDLH: 250 ppm
Basis for original (SCP) IDLH: The only quantitative acute inhalation toxicity data available are those cited by Patty [1963]. Patty [1963] reported that rats exposed for 8 hours to a saturated concentration of cresol vapors survived the exposure [Smyth 1956]. The chosen IDLH is based on the isomer with the highest vapor pressure, that of o璫resol, which yields a saturated concentration of 323 ppm at 25 C. The chosen IDLH appears to be conservative because no rats died as a result of this exposure which was for 8 hours. Based on the rat oral LD50 of 207 mg/kg for p璫resol [Biofax 1969 cited by NIOSH 1976], an IDLH of 250 ppm is reasonable.
Short璽erm exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal dose data:
|
|
| ||||
Cresols Rat Mouse Mouse |
Back et al. 1972 Back et al. 1972 Kuroki et al. 1982 | oral oral oral | 1,454 861 760 | ----- ----- ----- | 2,262 ppm 1,339 ppm 1,182 ppm | 226 ppm 134 ppm 118 ppm |
o-Cresol Rat Rat Mouse |
Biofax 1969b Deichmann and Witherup 1944 Gig Tr Prof Zabol 1974 | oral oral oral | 121 1,350 344 | ----- ----- ----- | 188 ppm 2,100 ppm 535 ppm | 19 ppm 210 ppm 54 ppm |
m-Cresol Rat Rat Mouse |
Biofax 1969a Deichmann and Witherup 1944 Gig Tr Prof Zabol 1974 | oral oral oral | 242 2,020 828 | ----- ----- ----- | 376 ppm 3,142 ppm 1,288 ppm | 38 ppm 314 ppm 129 ppm |
p-Cresol Rat Rat Mouse |
Biofax 1969c Deichmann and Witherup 1944 Gig Tr Prof Zabol 1974 | oral oral oral | 207 1,800 344 | ----- ----- ----- | 322 ppm 2,800 ppm 535 ppm | 32 ppm 280 ppm 54 ppm |
Other animal data: Rats exposed to a saturated concentration of cresol vapors (about 150 to 380 ppm) survived the exposure for 8 hours [Smyth 1956].
Human data: None relevant for use in determining the revised IDLH.
Revised IDLH: 250 ppm [Unchanged]
Basis for revised IDLH: Based on acute inhalation toxicity data in animals [Smyth 1956], the original IDLH for cresol (250 ppm) is not being revised at this time. |
REFERENCES:
1. Back KC, Thomas AA, MacEwen JD [1972]. Reclassification of materials listed as transportation health hazards. Wright璓atterson Air Force Base, OH: 6570th Aerospace Medical Research Laboratory, Report No. TSA��� pp. A�0 to A�1.
2. Biofax [1969a]. Data sheet 3�69. Northbrook, IL: Biofax Industrial Bio璗est Laboratories, Inc.
3. Biofax [1969b]. Data sheet 4�69. Northbrook, IL: Biofax Industrial Bio璗est Laboratories, Inc.
4. Biofax [1969c]. Data sheet 5�69. Northbrook, IL: Biofax Industrial Bio璗est Laboratories, Inc.
5. Deichmann WB, Witherup S [1944]. Phenol Studies. VI. The acute and comparative toxicity of phenol and o-, m-, and p璫resols for experimental animals. J Pharmacol Exp Ther 80:233�0.
6. Gig Tr Prof Zabol [1974]; 18(2):58� (in Russian).
7. Kuroki K, Murakami Y, Osumi T, Kimura T [1982]. A study on acute toxicity of formalin璯uaiacol. Kyushu Shika Gakkai Zasshi (Journal of the Kyushu Dental Society) 36(6):932�9 (in Japanese).
8. NIOSH [1976]. GO64750. p瑿resol. In: Registry of toxic effects of chemical substances, 1976 ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76�1, p. 353.
9. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1390.
10. Smyth HF Jr [1956]. Improved communication: hygienic standards
for daily inhalation. Am Ind Hyg Assoc Q 17(2):129�5.
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