Protocol Number: 04-H-0179
Normal healthy volunteers between 18 and 60 years of age may be eligible for this study. Candidates are screened with a medical history, physical examination, blood and urine tests, and electrocardiogram (EKG). Participants undergo the following tests and procedures: Day 1: - Blood draw for clinical monitoring and for research studies - Baseline abdominal ultrasound to measure spleen size - C-CSF injection under the skin Days 2 and 3: - G-CSF injections under the skin Day 4: - G-CSF injection - Blood draw for clinical monitoring and for research studies - Abdominal ultrasound to monitor for changes in spleen size - AMD3100 injection in the abdomen, arm, or thigh Day 5: - G-CSF injection - Blood draw for clinical monitoring and for research studies - Apheresis to collect stem cells. For this procedure, a catheter (plastic tube) is placed in a vein in each arm. Blood is withdrawn from one vein and circulated through a cell separator machine, which collects and saves stem cells and lymphocytes (a type of white blood cell) and returns the rest of the blood to the subject through the catheter in the vein in the other arm. The collected stem cells are not given to a patient, but are examined in the laboratory to see if they are suitable for transplant. - Blood draw to monitor for side effects - EKG - Abdominal ultrasound to monitor for changes in spleen size Days 10 through 12: - Telephone follow-up for review of symptoms - Blood draw to monitor for treatment side effects
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