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Protocol Number:
86-H-0088
- Title:
Lymphocytapheresis of Patients with Pancytopenia
- Number:
86-H-0088
- Summary:
Aplastic anemia is a condition in which the cells normally found in blood are greatly decreased. The normal levels of white blood cells, red blood cells, and platelets are much lower in patients with aplastic anemia.
Because of these low levels of blood cells, patients with aplastic anemia have a variety of immune system abnormalities. However, low levels of blood cells make it difficult to collect specialized white blood cells (mononuclear cells) for research studies.
This study was designed to collect lymphocytes from patients with low levels of all blood cells (pancytopenia) for use in research. Patients participating in the study will undergo a special procedure known as lymphapheresis. During lymphapheresis blood is taken from the patient in a manner similar to blood donation. The white blood cells are selectively removed by spinning (centrifugation), and the remaining red blood cells and platelets are placed back (re-infused) into the donor's blood stream.
Patients participating in this study will not benefit directly from it. However, cells collected in this study may increase scientific knowledge and improve understanding and treatment for diseases like aplastic anemia.
- Sponsoring Institute:
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National Heart, Lung and Blood Institute (NHLBI)
- Recruitment Detail
- Type:
Completed Study; data analyses ongoing
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Special Instructions:
Currently Not Provided
- Keyword(s):
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Bone Marrow Failure
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Lymphocytapheresis
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Pancytopenia
- Recruitment Keyword(s):
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Aplastic Anemia
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Hematosuppressive Disease
- Condition(s):
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Aplastic Anemia
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Pancytopenia
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Interventions:
- None
- Supporting Site:
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National Heart, Lung and Blood Institute
- Contact(s):
-
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Citation(s):
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Circulating activated suppressor T lymphocytes in aplastic anemia
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Interferon is a mediator of hematopoitic suppression in aplastic anemia in vitro and possibly in vivo
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Lymphokine abnormalities in aplastic anemia: implications for the mechanism of action of antithymocyte globulin
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/17/2009
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