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Protocol Number:
05-D-0052
- Title:
Stereo Photogrammetry Soft Tissue in Normal Individuals and Patients with Craniofacial Dysmorphologies
- Number:
05-D-0052
- Summary:
This study will use stereo photogrammetry to: 1) characterize facial features of genetic and congenital malformations; 2) define facial features associated with normal growth and development; and 3) determine if stereo photogrammetry soft tissue imaging can be used to help diagnose head and facial malformations. These abnormalities currently are diagnosed using 2- or 3-dimensional skeletal images obtained with x-rays. Stereo photogrammetry uses a camera and computer to generate 3-dimensional images of the soft tissues of the face. Because the method does not use any radiation, images can be taken repeatedly to evaluate patients over a long term.
Using stereo photogrammetry, images of people who belong to a defined group, for example, 17-year-old Caucasian males, can be combined (or morphed) into one image, allowing measurement of the facial features of the group. Comparing the morphed images of a normal control group with those of people with specific genetic conditions may reveal distinctions that could be used in diagnosing conditions that are currently diagnosed using x-rays.
Healthy normal volunteers and patients with craniofacial dysmorphologies may be eligible for this study. Patients are recruited from current NIH studies of various genetic diseases. People who have previously had head and neck surgeries, including cosmetic surgery, may not participate.
Participants give a medical and dental history, including any orthodontic work or facial surgeries. They are then positioned in front of a photogrammetry camera, a headband is placed on their head, and their picture is taken. A coded patient number is entered into the computer, where the image is stored until further analysis. Most participants are evaluated one time, but some patients and control subjects may be asked to return yearly for repeat images.
- Sponsoring Institute:
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National Institute of Dental And Craniofacial Research (NIDCR)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
None
- Eligibility Criteria:
INCLUSION CRITERIA:
-Male and female subjects of all ages and racial groups will be included. The lower age limit will be determined by the ability to cooperate with imaging.
-Patients will be recruited from current NIH Intramural populations with various defined genetic diseases such as Fanconi anemia.
-Controls will be recruited from the immediate families of individuals with genetic or congenital disease, phenotypically normal subjects participating in other NIH studies, or normal populations at collaborating institutions.
EXCLUSION CRITERIA:
-Patients or controls with past head and neck surgeries including cosmetic facial surgery.
-Patients unable to cooperate with imaging.
- Special Instructions:
Currently Not Provided
- Keywords:
-
Facial Imaging
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Genetics
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Growth
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Development
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Diagnostics
- Recruitment Keyword(s):
-
Craniofacial Dysmorphologies
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Facial Imaging
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Facial Features
- Condition(s):
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Craniofacial Abnormalities
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Institute of Dental and Craniofacial Research
- Contact(s):
-
Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
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Li Y, Shum HY, Tang CK, Szeliski R. Stereo reconstruction from multiperspective panoramas. IEEE Trans Pattern Anal Mach Intell. 2004 Jan;26(1):45-62.
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Hart TC, Marazita ML, Wright JT. The impact of molecular genetics on oral health paradigms. Crit Rev Oral Biol Med. 2000;11(1):26-56. Review.
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Szeliski R, Scharstein D. Sampling the disparity space image. IEEE Trans Pattern Anal Mach Intell. 2004 Mar;26(3):419-25.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/17/2009
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