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Protocol Number:
02-C-0179
- Title:
Collection of Blood from Patients with Cancer
- Number:
02-C-0179
- Summary:
This study will collect blood from patients with cancer to study the level of cells which decrease the immune response (suppressor cells) before and after chemotherapy. Patients 18 years of age and older with cancer may participate. This study does not involve treatment.
Participants will have about 50 ml (3 tablespoonfuls) of blood drawn. Depending on their condition, patients may be invited to enroll in a clinical research study involving chemotherapy, radiotherapy, or surgery. Additional 40-ml blood samples may be drawn during the course of treatment.
- Sponsoring Institute:
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National Cancer Institute (NCI)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
INCLUSION CRITERIA:
Patients 18 years of age and older are eligible.
Patients must have a performance status of ECOG 0, 1, 2, or 3 for admission to this protocol.
Patients with malignancy are eligible.
EXCLUSION CRITERIA:
Children will not be eligible.
- Special Instructions:
Currently Not Provided
- Keywords:
-
Suppressor Cells
-
T Cells
-
CD4+/CD25+ Cells
- Recruitment Keyword(s):
-
Cancer
-
Malignancy
-
Blood Sample
- Condition(s):
-
Neoplasms
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Cancer Institute
- Contact(s):
-
NCI Referral Office
National Institute of Health Clinical Center (CC), 9000 Rockville Pike, Bethesda, Maryland 20892, United States: NCI Clinical Trials Referral Office Phone: 1-888-NCI-1937 Fax: Not Listed Electronic Address: ncicssc@mail.nih.gov
- Citation(s):
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Shimizu J, Yamazaki S, Sakaguchi S Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity J Immunol 1999 Nov 15;163(10):5211-8
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Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolatedfrom peripheral blood J Exp Med 2001 Jun 4;193(11):1285-94
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Levings MK, Sangregorio R, Roncarolo MG Related Articles Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitrowithout loss of functionJ Exp Med 2001 Jun 4;193(11):1295-302
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/17/2009
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