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Protocol Number:
96-M-0124
- Title:
Genetics of Obsessive-Compulsive Disorder: A Collaborative Study
- Number:
96-M-0124
- Summary:
The purpose of this study is to identify genes that affect susceptibility to obsessive-compulsive disorder (OCD). By identifying genes that increase or decrease the risk of OCD, researchers can better understand how the condition develops and ultimately improve treatment for people with OCD.
OCD is a severe, familial condition that affects approximately 2% of the population. The way OCD is inherited is not clearly understood, but researchers believe it is complex and involves multiple genes. This study will detect and localize genes that increase or decrease susceptibility to OCD. The data collected from this study will be combined with data from other research studies to determine gene linkage and association.
- Sponsoring Institute:
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National Institute of Mental Health (NIMH)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
INCLUSION CRITERIA
Must have a diagnosis of obsessive-compulsive disorder, or be a family member (usually a parent or sibling) of someone with obsessive-compulsive disorder.
Certain disorders are considered part of OCD "spectrum" disorders and often include family members with OCD. These include Tourette's Syndrome, other individuals with tics, and Trichotillomania (severe hair pulling), and other forms of repetitive behaviors.
Persons with primary behavioral difficulties who do no fit with the current definitions of "OCD and OCD spectrum disorders" may not be eligible. These include compulsive shopping, gambling, or compulsive sexual behaviors.
- Special Instructions:
You may call toll free at 866-644-4363 or collect at 31-496-8977.
- Keywords:
-
Genetic
-
Psychiatric Disorder
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Affected Sib Pairs
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Obsessions
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Compulsions
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Family Study
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OCD Spectrum Disorders
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Trichotillomania
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Tourette's Syndrome
- Recruitment Keyword(s):
-
None
- Condition(s):
-
Obsessive Compulsive Disorder
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Institute of Mental Health
- Contact(s):
-
Diane M. Kazuba
National Institutes of Health Building 10 Room 3D41 10 Center Drive Bethesda, Maryland 20892 Phone: (301) 496-8977 Fax: (301) 402-0188 Electronic Address: kazubad@intra.nimh.nih.gov
- Citation(s):
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Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, Lesch KP, Hamer D, Murphy DL. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet. 2000 Apr 3;96(2):202-16.
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Enoch MA, Greenberg BD, Murphy DL, Goldman D. Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder. Biol Psychiatry. 2001 Feb 15;49(4):385-8.
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Murphy DL, Li Q, Engel S, Wichems C, Andrews A, Lesch KP, Uhl G. Genetic perspectives on the serotonin transporter. Brain Res Bull. 2001 Nov 15;56(5):487-94. Review.
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Bengel D, Greenberg BD, Cora-Locatelli G, Altemus M, Heils A,Li Q, Murphy DL. Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder. Mol Psychiatry. 1999 Sep;4(5):463-6.
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Enoch MA, Kaye WH, Rotondo A, Greenberg BD, Murphy DL, Goldman D. 5-HT2A promoter polymorphism -1438G/A, anorexia nervosa, and obsessive-compulsive disorder. Lancet. 1998 Jun 13;351(9118):1785-6. No abstract available.
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Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, OttJ, Gogos JA. Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4572-5.
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Altemus M, Murphy DL, Greenberg B, Lesch KP. Intact coding region of the serotonin transporter gene in obsessive-compulsive disorder. Am J Med Genet. 1996 Jul 26;67(4):409-11.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 01/17/2009
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