CGAP Info
CGAP Data
Quick Links:
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The CANCER GENOME
ANATOMY PROJECT
The goal of the NCI's Cancer Genome Anatomy Project is to determine the gene
expression profiles of normal, precancer, and cancer cells, leading eventually to
improved detection, diagnosis, and treatment for the patient.
By collaborating with scientists worldwide,
CGAP
seeks to increase its scientific expertise and expand its databases for the benefit of all cancer researchers.
The CGAP Web Site
Interconnected modules provide access to all CGAP data, bioinformatic analysis tools, and biological resources
allowing the user to find "in silico" answers to biological
questions in a fraction of the time it once took in the laboratory.
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Genes Gene information, clone resources, SNP500Cancer, GAI, and
transcriptome analysis |
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Chromosomes FISH-mapped BAC clones, SNP500Cancer, and the Mitelman
database of chromosome aberrations
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Tissues
cDNA library information, methods, and EST-based gene expression analysis
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SAGE Genie
Analysis of gene expression using long and
short SAGE tag data for both human and
mouse |
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Pathways
Diagrams of biological pathways and protein complexes, with links to genetic
resources for each known protein
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Tools
Direct access to all analytic and data mining tools developed for the project |
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RNAi
RNA-interference constructs, targeted specifically against cancer relevant genes.
New addition: Validated set of shRNAs targeted to cancer genes. |
New Initiatives
- The NCI supports the Initiative for Chemical Genetics (ICG),
which is developing a systematic approach for harnessing synthetic chemistry to discover molecular
mechanisms in basic cell biology. This approach aims to emulate the success of classical genetics
as a discovery platform using chemicals that alter the function of specific proteins in place of mutations.
These results will be incorporated into the Gene Info pages of the relevant genes.
- The OCG/NCI and NHGRI recently convened a workshop to assess the value of a project to catalogue
all of the DNA sequence changes that occur in tumorigenesis. A summary of the workshop and
its recommendations are available at Exploring Cancer through Genomic Sequence Comparisons.
Follow-up information will be posted on the CGAP web site as it becomes available.
- In July 2005, the NCI and NHGRI convened a workshop in Washington, DC entitled “Toward a Comprehensive Genomic Analysis of Cancer?.
This meeting brought together physicians, basic scientists, and other members of the U.S. and international cancer communities
to assist in outlining the most effective strategies for the development of a successful pilot phase of the human cancer genome
characterization project. Additional information about this meeting is reported in the
Executive Summary.
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