The Registry of Toxic Effects of Chemical Substances
Zinc oxide |
UPDATE: May 2008 | MW: 81.37 | MF: OZn |
SYNONYMS:
|
|
|
SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
eye | rabbit
500 mg/24 hour
|
mild
|
28ZPAK -,10,1972
|
skin | rabbit
500 mg/24 hour
|
mild
|
28ZPAK -,10,1972
|
|
MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
cytogenetic analysis
|
human
other cell types
|
100 µmol/L/30 hour
|
MUREAV 650,39,2008
|
cytogenetic analysis
|
inhalation | rat
100 µg/m3
|
CYGEDX 12(3),46,1978
|
DNA adduct
|
Escherichia coli
|
3,000 ppm
|
MUREAV 89,95,1981
|
unscheduled DNA synthesis
|
inhalation | guinea pig
5,300 µg/m3/3 hour/6 day
|
TXAPA9 78,29,1985
|
unscheduled DNA synthesis
|
hamster
embryo
|
1 mg/L
|
SHIGAZ 74,1385,1987
|
morphological transform
|
hamster
embryo
|
1 mg/L
|
SHIGAZ 74,1385,1987
|
sister chromatid exchange
|
hamster
embryo
|
300 µg/L
|
SHIGAZ 74,1385,1987
|
|
REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
oral | rat
lowest published toxic dose: 6,846 mg/kg (1-22 day pregnant)
|
Reproductive: Specific developmental abnormalities: Homeostasis | Reproductive: Effects on newborn: Stillbirth Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JONUAI 98,303,1969
|
|
TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
|
ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | human
lowest published toxic concentration: 600 mg/m3
|
Lung, Thorax, or Respiration: Cough | Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes
JIDHAN 9,88,1927
|
inhalation | mouse
lethal concentration (50 percent kill): 2,500 mg/m3
|
N/R
|
ENTOX* -,481,2005
|
inhalation | rat
lowest published toxic concentration: 25 mg/m3/3 hour
|
Lung, Thorax, or Respiration: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 72,298,2003
|
inhalation | rat
lowest published toxic concentration: 25 mg/m3/3 hour
|
Lung, Thorax, or Respiration: Other changes | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 44,213,2005
|
intraperitoneal | rat
lethal dose (50 percent kill): 240 mg/kg
|
N/R
|
ZDKAA8 38(9),18,1978
|
intratracheal | mammal (species unspecified)
lowest published toxic dose: 250 mg/kg
|
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | Lung, Thorax, or Respiration: Other changes
VCVN1* -,151,1988
|
intratracheal | rat
lethal dose : >4,979 µg/kg
|
Lung, Thorax, or Respiration: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
ESKGA2 35,P19,1989
|
oral | human
lowest published lethal dose: 500 mg/kg
|
N/R
|
YAKUD5 22,291,1980
|
oral | mouse
lethal dose (50 percent kill): 7,950 mg/kg
|
N/R
|
ENTOX* -,481,2005
|
oral | rat
lethal dose : >8,437 mg/kg
|
N/R
|
GTPZAB 18(5),48,1974
|
|
OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | guinea pig
lowest published toxic concentration: 5,900 µg/m3/3 hour/3 day- intermittent
|
Lung, Thorax, or Respiration: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
JTEHD6 25,57,1988
|
inhalation | guinea pig
lowest published toxic concentration: 4,600 µg/m3/3 hour/6 day- intermittent
|
Lung, Thorax, or Respiration: Other changes | Lung, Thorax, or Respiration: Changes in lung weight
TXAPA9 78,29,1985
|
inhalation | mammal (species unspecified)
lowest published toxic concentration: 15 mg/m3/1 hour/84 day- intermittent
|
Lung, Thorax, or Respiration: Dyspnea | Lung, Thorax, or Respiration: Other changes
VCVN1* -,153,1988
|
inhalation | rat
lowest published toxic concentration: 6.9 mg/m3/7 day- intermittent
|
Lung, Thorax, or Respiration: Other changes | Lung, Thorax, or Respiration: Changes in lung weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
INHTE5 15,435,2003
|
oral | chicken
lowest published toxic dose: 32,203 mg/kg/4 week- continuous
|
Endocrine: Change in GH | Endocrine: Evidence of thyroid hypofunction Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 57,309,1991
|
oral | chicken
lowest published toxic dose: 6,468 mg/kg/1 week- intermittent
|
Endocrine: Evidence of thyroid hypofunction | Blood: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 57,309,1991
|
oral | chicken
lowest published toxic dose: 12.93 gm/kg/2 week- intermittent
|
Endocrine: Change in GH
|
TOLED5 57,309,1991
|
oral | chicken
lowest published toxic dose: 25.87 gm/kg/4 week- intermittent
|
Endocrine: Other changes
|
TOLED5 57,309,1991
|
oral | domestic animal
lowest published toxic dose: 3,584 mg/kg/4 week- intermittent
|
Gastrointestinal: Changes in structure or function of exocrine pancreas | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Changes in: Other metals
JJATDK 4,92,1984
|
oral | rat
lowest published toxic dose: 17,431 mg/kg/90 day- continuous
|
Behavioral: Change in motor activity (specific assay)
|
TOXID9 36(1 Pt2),183,1997
|
|
REVIEWS:
ORGANIZATION
|
STANDARD
|
| REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
time-weighted average 2 mg/m3;short term exposure limit 10 mg/m3 (respirable)
|
DTLVS* TLV/BEI,2007
|
TOXICOLOGY REVIEW
|
|
ANAEA3 35,165,1975
|
TOXICOLOGY REVIEW
|
|
JIDHAN 8,322,1926
|
TOXICOLOGY REVIEW
|
|
ENTOX* -,481,2005
|
|
STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
| REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
|
PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
|
FEREAC 54,7740,1989
|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
|
PESTICIDES: RED Completed
|
RBREV* -,346,1998
|
Mine Safety and Health Administration (MSHA) STANDARD - air
|
time-weighted average 5 mg/m3 (fume)
|
DTLVS* 3,284,1971
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
|
8 hour time-weighted average 5 mg/m3, fume and respirable fraction
|
CFRGBR 29,1910.1000,1994
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
|
8 hour time-weighted average 15 mg/m3, total dust
|
CFRGBR 29,1910.1000,1994
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
|
8 hour time-weighted average 5 mg/m3, fume and respirable fraction
|
CFRGBR 29,1926.55,1994
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
|
8 hour time-weighted average 15 mg/m3, total dust
|
CFRGBR 29,1926.55,1994
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
|
8 hour time-weighted average 5 mg/m3, fume and respirable fraction
|
CFRGBR 29,1915.1000,1993
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
|
8 hour time-weighted average 15 mg/m3, total dust
|
CFRGBR 29,1915.1000,1993
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
|
8 hour time-weighted average 5 mg/m3
|
CFRGBR 41,50-204.50,1994
|
Occupational Exposure Limit - ARAB Republic of Egypt
|
time-weighted average 5 mg/m3, JAN1993
|
Occupational Exposure Limit - AUSTRALIA
|
time-weighted average 10 mg/m3, JAN1993
|
Occupational Exposure Limit - AUSTRALIA
|
time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3 (fume), JAN1993
|
Occupational Exposure Limit - BELGIUM
|
time-weighted average 10 mg/m3, JAN1993
|
Occupational Exposure Limit - BELGIUM
|
time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3 (fume), JAN1993
|
Occupational Exposure Limit - DENMARK
|
time-weighted average 4 mg/m3 (fume), OCT 2002
|
Occupational Exposure Limit - FINLAND
|
time-weighted average 5 mg/m3 (fume), JAN1999
|
Occupational Exposure Limit - FRANCE
|
VME 10 mg/m3 (dust), 5 mg/m3 (fume), FEB2006
|
Occupational Exposure Limit - GERMANY
|
MAK 1 mg/m3 (respirable, fume), 2005
|
Occupational Exposure Limit - HUNGARY
|
time-weighted average 5 mg/m3, JAN1993
|
Occupational Exposure Limit - JAPAN
|
Occupational Exposure Limit Pending (fumes), APR2007
|
Occupational Exposure Limit - JAPAN
|
Occupational Exposure Limit 1 mg/m3 (respirable), 4 mg/m3 (total), APR2007
|
Occupational Exposure Limit - KOREA
|
time-weighted average 10 mg/m3, 2006
|
Occupational Exposure Limit - KOREA
|
time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, 2006
|
Occupational Exposure Limit - MEXICO
|
time-weighted average 5 mg/m3 (fume), 2004
|
Occupational Exposure Limit - MEXICO
|
time-weighted average 10 mg/m3; | short term exposure limit 10 mg/m3 (inhalable), 2004
Occupational Exposure Limit - THE NETHERLANDS
|
MAC-TGG 5 mg/m3, 2003
|
Occupational Exposure Limit - NEW ZEALAND
|
time-weighted average 5 mg/m3 (fume), short term exposure limit 10 ppm (fume), JAN2002
|
Occupational Exposure Limit - NEW ZEALAND
|
time-weighted average 10 mg/m3 (inspirable dust), JAN2002
|
Occupational Exposure Limit - NORWAY
|
time-weighted average 5 mg/m3, JAN1999
|
Occupational Exposure Limit - THE PHILIPPINES
|
time-weighted average 1 mg/m3, JAN1993
|
Occupational Exposure Limit - POLAND
|
MAC(time-weighted average) fume 5 mg/m3, MAC(short term exposure limit) fume 10 mg/m3, JAN1999
|
Occupational Exposure Limit - RUSSIA
|
time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JUN2003
|
Occupational Exposure Limit - SWEDEN
|
time-weighted average 5 mg/m3, JUN2005
|
Occupational Exposure Limit - SWITZERLAND
|
MAK- week 3 mg/m3,KZG- week 0.125 mg/m3 (fume), DEC2006
|
Occupational Exposure Limit - THAILAND
|
time-weighted average 5 mg/m3 (fume), JAN1993
|
Occupational Exposure Limit - TURKEY
|
time-weighted average 5 mg/m3, JAN1993
|
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | time-weighted average 2 mg/m3; short term exposure limit 10 mg/m3 (respirable)
Occupational Exposure Limit IN SINGAPORE, VIETNAM
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
time-weighted average 2 mg/m3; short term exposure limit 10 mg/m3 (respirable) |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
| REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ZINC OXIDE, fume-air
|
10 hour time-weighted average 5 mg/m3; | short term exposure limit 10 mg/m3
NIOSH* DHHS #92-100,1992
|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ZINC OXIDE, total dust-air
|
time-weighted average 5 mg/m3; | ceiling concentration 15 mg/m3/15 minute
NIOSH* DHHS #92-100,1992
|
National Occupational Exposure Survey 1983
|
National Occupational Exposure Survey 1983: Hazard Code: X5686 | ![]() Number of Industries 295; Total Number of Facilities 56,635; Number of Occupations 168; Total Number of Employees Exposed 919,197; Total Number of Female Employees Exposed 151,582
National Occupational Exposure Survey 1983
|
National Occupational Exposure Survey 1983: Hazard Code: X9509 |
![]() Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 105; Total Number of Female Employees Exposed 7 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
|
| REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
|
Used as an antiinflammatory agent
|
EPA TSCA Section 8(d) unpublished health/safety studies
|
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
|
NIOSH Analytical Method, 1994: Elements by ICP, 7300
|
NIOSH Analytical Method, 1994: Zinc and compounds, 7030 or 7502
|
OSHA ANALYTICAL METHOD #ID121
|
OSHA ANALYTICAL METHOD #ID143
|
|
REFERENCES:
CODEN
|
| REFERENCE
28ZPAK
|
"Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro
Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
|
ANAEA3
|
Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1-
1943-
|
CFRGBR
|
Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
|
CYGEDX
|
Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc.,
150 Fifth Ave., New York, NY 10011) V.8- 1974-
|
DTLVS*
|
The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
|
ENTOX*
|
Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
|
ESKGA2
|
Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo
150, Japan) V.1- 1953-
|
FEREAC
|
Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
|
GTPZAB
|
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see
MTPEEI
|
INHTE5
|
Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P
4EE) V.1- 1989-
|
JIDHAN
|
Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information,
see AEHLAU.
|
JJATDK
|
JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W.
Sussex PO19 1UD, UK) V.1- 1981-
|
JONUAI
|
Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1-
1928-
|
JTEHD6
|
Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW,
Washington, DC 20005) V.1- 1975/76-
|
MUREAV
|
Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
|
NIOSH*
|
National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
|
RBREV*
|
Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report),
Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental
Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
|
SHIGAZ
|
Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102,
Japan) V.38- 1949-
|
TOLED5
|
Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
|
TOXID9
|
Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
|
TXAPA9
|
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
|
VCVN1*
|
"Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous
substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
|
YAKUD5
|
Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho,
Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
|
ZDKAA8
|
Zdravookhranenie Kazakhstana. Public Health of Kazakhstan. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1941-
|
|