National Toxicology Program

CASRN: 333-41-5

Formula: C12 H21 N2 O3 P S

Synonyms/Common Names:

• PHOSPHOROTHIOIC ACID, 0,0-DIETHYL O-(6-METHYL-2-(1-METHYLETHYL)-4-PYRIMIDINYL) ESTER (9CI)

Known Uses:

PESTICIDE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C08673) Completed 
  • NTIS No. PB293889  (Peer Review 12/13/1978)
    Citation: Bioassay of Diazinon for Possible Carcinogenicity (CAS No. 333-41-5)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C08673) Completed 
  • NTIS No. PB293889  (Peer Review 12/13/1978)
    Citation: Bioassay of Diazinon for Possible Carcinogenicity (CAS No. 333-41-5)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,50,3200 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C08673) Report Complete 
  • TR-137 (NTIS No. PB293889)  (Peer Review 12/13/1978)
    Bioassay of Diazinon for Possible Carcinogenicity (CAS No. 333-41-5)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,400,800, M: 0,100,200 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (140422) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (180250) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Salmonella (NCI)  (N-9278) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Negative 
• Salmonella  (217556) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Negative