National Toxicology Program

CASRN: 108-46-3

Related: TRANSGENIC MODEL EVALUATION (RESORCINOL)

Formula: C6-H6-O2

Synonyms/Common Names:

• 1,3-BENEZENEDIOL (9CI)

Known Uses:

TANNING, CHEMICAL PRODUCTION, DYES, COSMETICS, PHARMACEUTICALS, PHOTOGRAPHY, INTERMEDIATE.

Short-Term Toxicity

• 14-Day (Gavage)  (C05970A) Completed 
  • NTIS No. PB93-126381  (Peer Review 03/11/1991)
    Citation: Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1; Rats: F344/N
• 13-Week (Gavage)  (C05970A) Completed 
  • NTIS No. PB93-126381  (Peer Review 03/11/1991)
    Citation: Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1; Rats: F344/N
  • Dose: R: 0,32,520, M: 0,28,420 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C05970A) Report Complete 
  • TR-403 (NTIS No. PB93-126381)  (Peer Review 03/11/1991)
    Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1; Rats: F344/N
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: MR&M: 0,112,225 FR: 0,50,100,150 MG/KG/60 PER GROUP

Special Studies

• Metabolism  (S0713) Completed 
  • Citation: KIM., Y.C. & MATTHEWS, H.B., COMPARATIVE METABOLISM & EXCRETION OF RESORCINOL IN MALE AND FEMALE 344 RATS, FUNDAMENTAL & APPLIED TOXICOLOGY 9, 409-414, 1987
  • M/F Rats: F344

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (101147) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (126256) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Inconclusive 
• Mouse Lymphoma  (743596) Completed 
  • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
  •  Positive 
• Micronucleus  (A90027) Completed 
  • Mice: B6C3F1
  • Male Positive 
• Salmonella  (674324) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative