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When
planning your research, consider whether you can achieve your scientific
objectives while reducing the number of animals, refining the use of
animals by minimizing their pain or distress, or even better, not using
them
at
all.
USDA regulations
require that investigators search the scientific literature for alternatives,
but if this isn't done until the IACUC approval
stage, most researchers will have already determined
what animals they are going to use and how.
Considering alternatives during the planning stage gives you enough
time to incorporate methods that benefit the animals and the science.
It also shows peer
reviewers that you are thorough and reduces your chances of
a bar
to award because of animal
welfare concerns.
Limit Animal Use and Discomfort
- Limit animal involvement by using
the minimum number required to obtain valid results.
- Use non-animal
methods, such as mathematical models, computer simulation, or in vitro biological
systems.
- Avoid or minimize animal discomfort, distress, and pain
as is consistent with sound scientific practices.
- Use appropriate
sedation, analgesia, or anesthesia when your procedures will cause
more than momentary pain or distress. Do not perform surgical
or other painful procedures on non-anesthetized animals.
Resources
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