Table of Contents
Preclinical Studies
Tegaserod Carcinogenicity Studies
Increased Incidence of Intestinal Tumors in Tegaserod Mouse Carcinogenicity Study
Mouse Small Intestinal Tumors
Body Weight Curves in the Tegaserod Mouse Carcinogenicity Study
Tegaserod Has No Mutagenic Potential
Tegaserod Induces Reversible Hyperplasia in Mouse Intestinal Mucosa
Tumors Result From Epigenetic Effects
Sustained Hyperplasia Is Required for Tumor Formation
The Tumor Incidence Was Only Increased at a Very High Tegaserod Dose
Tegaserod Therapy Poses No Carcinogenic Risk
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Author: Sector Pharma
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