Testing Information

Testing Status of Agents at NTP

Methyl parathion

Print this pageFriendly URL

http://ntp.niehs.nih.gov/go/TS-10608-X

CASRN: 298-00-0

Formula: C8-H10-N-O5-P-S

Synonyms/Common Names:

  • O,O-DIMETHYLPHOSPHOROTHOIC ACID-O-(4-NITROPHENYL)ESTER (9CI)

Known Uses:

INSECTICIDE

Short-Term Toxicity

  • 13-WEEK (Dosed-Feed)  (C02971) Completed 
    • NTIS No. PB295891  (Peer Review 12/15/1978)
      Citation: Bioassay of Methyl Parathion for Possible Carcinogenicity (CAS No. 298-00-0)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,10,50, M: 0,20,500 PPM/5 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Feed)  (C02971) Report Complete 
    • TR-157 (NTIS No. PB295891)  (Peer Review 12/15/1978)
      Bioassay of Methyl Parathion for Possible Carcinogenicity (CAS No. 298-00-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0,20,40, MM: 0,35,77 (AVG), FM: 0,62.5,125 PPM/50 PER GROUP

Special Studies

  • C. elegans  (S0903) Completed 
    • Nematode: C. elegans
    • Dose: feed: (0,.002,.0032,.005,.0079,.013,.02,.032,.05,.079,.13,.2) mM 2/19/06; repro: (0,.004,.005,.0063,.0079,.01,.013,.02,.025,.032,.04) mM 02/24/06 growth: (0,1,1.6,2.5,4,6.3,10,16,25,40,63,100) uM 07/09/07

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (433667) Completed 
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • Salmonella  (049060) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 

Back to top

Web page last updated on November 24, 2008