Research Workshop to be held at the
National Institutes of Health
Lister Hill Auditorium
December 10-11, 1998
Bethesda, MD
The aim of this meeting is to synthesize current understanding of the condition known as
non-alcoholic steatohepatitis (NASH) and to outline specific areas of future research in
better defining its etiology, natural history and treatment.
December 10, 1998 (Thursday)
Session 1: NASH - The Clinical Syndrome: Jay Hoofnagle and Jackie Maher
8:30 a.m.
8:40 alm.
9:00 a.m.
9:20 a.m.
9:40 a.m.
10:00 a.m.
10:20 a.m. |
Welcome
What is NASH? Overview
Clinical Features of NASH
Natural History of NASH
Obesity and Liver Disease
Discussion
Break |
Jay Hoofnagle, NIH
Bruce Bacon, St. Louis University
Arun Sanyal, MCV, Richmond, VA
Arthur McCullough, Metro. Cleveland
Jay Everhart, NIH |
Session 2: NASH - Clinical Correlations: Oliver James
and Tom Boyer
10:50 a.m.
11:10 a.m.
11:30 a.m.
11:50 a.m.
12.10 p.m.
12:30 p.m. |
NASH in Children
Diabetes and Liver Disease
Insulin Resistance and NASH
NASH and Liver Transplantation
Discussion
Lunch |
Joel Lavine, UCSD, CA
Ian Wanless, Toronto, Canada
David Herion, NIH
Michael Sorrell, Omaha, NE |
Session 3: Pathology of NASH - Moderators: Jay
Lefkowitch and Randy Lee
1:30 p.m.
1:50 p.m.
2:10 p.m.
2:30 p.m.
2:50 p.m.
3:10 p.m. |
Pathology of NASH
Grading and Staging
Roundtable Discussion
Iron and NASH
Non-invasive diagnosis
Break |
Zack Goodman, AFIP
David Kleiner, NIH
Goodman, Brunt, Kleiner, Lefkowitch,
Lee, Ludwig and Wanless
Herb Bonkovsky, Univ. of Mass.
Tom Boyer, Emory |
Session 4: Pathogenesis of Steatosis and NASH: Anna Mae
Diehl and Simeon Taylor
3:30 p.m.
3:50 p.m.
4:10 p.m.
4:30 p.m.
4:50 p.m.
5:20 p.m.
6:00 p.m.
7:30 p.m. |
Pathogensis of NASH:
Overview
Hepatic Fab Metabolism
CYP450 and NASH
Cox-2, Inflammation and the Liver
Discussion
Posters
Adjourn
Dinner Banquet |
Nathan Bass, UCSF
Robert Wolfe, Galveston, TX
Geoffrey Farrel, Sydney, Australia
Andrew Dannenberg, Cornell |
December 11, 1998 (Friday)
Session 5: Pathophysiology of Steatosis and Liver Injury: Bruce Bacon and
Geoffrey Farrell
8:30 a.m.
8:50 a.m.
9:10 a..m.
9:30 a.m.
9:50 a.m.
10.20 a.m. |
Alcohol injury and NASH
Cytokines and NASH
Mitochondrial injury and NASH
Animal Models of NASH
Discussion
Break |
Jackie Maher, UCSF, San
Francisco
Craig McClain, Univ. Kentucky
Dominique Pessayre, Paris
Anna Mae Diehl, Johns Hopkins |
Session 6: Treatment of NASH - Moderators: Arun Sanyal
and Joel Lavine
10:50 a.m.
11:10 a.m.
11:30 a.m.
12:00 p.m. |
Weight loss and NASH
Anti-oxidants and NASH
Discussion
Synthesis and Conclusions |
Oliver James, Newcastle on Tyne,
UK
Keith Lindor, Mayo Clinic
Jay Hoofnagle, NIH |
For further information or to register for the
meeting, contact
Ms. Tracy Morgan, Conference Manager
(301) 493-9674 or
E-mail: Morgan@ccc76.com
Registration deadline: Monday, November 30, 1998 (space
is limited)
Registration fee: $75 |