Volume 10, Number 11, November 2004

Topographic Changes in SARS Coronavirus–infected Cells at Late Stages of Infection

M.L. Ng,* J.W.M. Lee,* M.L.N. Leong,* A.-E. Ling,† H.-C. Tan‡ and E.E. Ooi‡
*National University of Singapore, Singapore; †Singapore General Hospital, Singapore; and ‡National Environment Agency, Singapore

Figure 6. Atomic force microscopy of Vero cells infected with severe acute respiratory syndrome–associated coronavirus. A) High activity of virus extrusion at the thickened edge of the infected cells (arrow). Arrowheads indicate virus particles. B) A three-dimensional reconstruction of the image in panel A shows the puffy edge of infected cells. Many intracellular viruses are visible just under the plasma membrane (arrows). Extruded virus particles are present on other areas of the cell surface (arrowheads). Thick white arrow shows a large clump of virus particles just beneath the plasma membrane.

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This page last reviewed October 12, 2004

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
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