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Vol. 9, No. 7
July 2003

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Research

Emergence and Global Spread of a Dengue Serotype 3, Subtype III Virus

William B. Messer,* Duane J. Gubler,† Eva Harris,‡ Kamalanayani Sivananthan,§ and Aravinda M. de Silva*
*University of North Carolina, Chapel Hill, North Carolina, USA; †Centers for Disease Control and Prevention, Fort Collins, Colorado, USA; ‡University of California, Berkeley, California, USA; and §Medical Research Institute, Colombo, Sri Lanka

 

Table 1. Dengue virus type 3 sequences useda

Strain

Y

Location

Name

Subtype

Sequence source

GenBank accession no.

D1266

1983

Sri Lanka

83SriLan1

III

This study

AF547225

D1306

1983

Sri Lanka

83SriLan2

III

This study

AF547226

D1307

1983

Sri Lanka

83SriLan3

III

This study

AF547227

D1336

1983

Sri Lanka

83SriLan4

III

This study

AF547228

D1440

1984

Sri Lanka

84SriLan1

III

This study

AF547229

073

1985

Sri Lanka

85SriLan

III

This study

AF547241

D2783

1989

Sri Lanka

89SriLan1

III

This study

AF547230

D2863

1989

Sri Lanka

89SriLan2

III

This study

AF547231

D2803

1989

Sri Lanka

89SriLan3

III

This study

AF547232

D3197

1990

Sri Lanka

90SriLan1

III

This study

AF547233

D5231

1993

Sri Lanka

93SriLan1

III

This study

AF547234

D9397

1994

Sri Lanka

94SriLan1

III

This study

AF547235

L57

1997

Sri Lanka

97SriLan1

III

This study

AF547242

K1

1998

Sri Lanka

98SriLan

III

This study

AF547243

1557

1985

Mozambique

85Mozamb1

III

This study

AF547236

1558

1985

Mozambique

85Mozamb2

III

This study

AF547237

1559

1985

Mozambique

85Mozamb3

III

This study

AF547238

251991

1991

Kenya

91Kenya

III

This study

AF547239

SOM079

1993

Somalia

93Somalia

III

This study

AF547240

32267

1994

Nicaragua

94Nicara1

III

This study

AF547244

6845

1998

Nicaragua

98Nicara1

III

This study

AF547245

7431

1998

Nicaragua

98Nicara2

III

This study

AF547246

7071

1998

Nicaragua

98Nicara3

III

This study

AF547262

BC 96/94

1994

Panama

94Panama1

III

This study

AF547247

032231

1994

Panama

94Panama2

III

This study

AF547248

BC 13/96

1994

Panama

94Panama3

III

This study

AF547249

BC 20/97

1996

Mexico

96Mexico1

III

This study

AF547250

BC 172/97

1996

Mexico

96Mexico2

III

This study

AF547251

BC 184/97

1996

Mexico

96Mexico3

III

This study

AF547252

BC173/97

1996

Mexico

96Mexico4

III

This study

AF547253

17605

1995

Costa Rica

95CostaR1

III

This study

AF547254

17608

1995

Costa Rica

95CostaR2

III

This study

AF547255

322473

1995

Costa Rica

95CostaR3

III

This study

AF547256

322488

1995

Costa Rica

95CostaR4

III

This study

AF547257

20/8

1997

Guatemala

97Guatem1

III

This study

AF547263

366-781

1998

Puerto Rico

98PuertoR1

III

This study

AF547258

400-996

2000

Puerto Rico

00PuertoR1

III

This study

AF547264

MK

1998

El Salvador

98ElSalv1

III

This study

AF547259

612210

2001

Venezuela

01Venezue1

III

This study

AF547260

VEN03

2001

Venezuela

01VEN03

III

This study

AF547261

Ref. 18

1981–91

Sri Lanka

81,85,89,91 SriLanA

III

GenBank

L11431,L11436–L11438

Ref. 18

1984

India

84IndiaA

III

GenBank

L11424

Ref. 18

1986

Samoa

86Samoa

III

GenBank

L11435

Ref. 18

1962–86

Thailand

62,73,86,86 Thailand

II

GenBank

L11440–L11442,L11620

Ref. 18

1983

Philippines

83Philipp

I

GenBank

L11432

Ref. 18

1989

Tahiti

89Tahiti

I

GenBank

L111619

Ref. 18

1992

Fiji

92Fiji

I

GenBank

L11422

Ref. 18

1973–85

Indonesia

73,78,85 Indones

I

GenBank

L11425,L11426,L11428

Ref. 18

1974–81

Malaysia

74,81 Malaysi

I

GenBank

L11429,L11427

Ref. 18

1956

Philippines

D3H-87

I

GenBank

L11423

Ref. 18

1963–77

Puerto Rico

63,77 PuertoR

IV

GenBank

L11433,L11434

Ref. 18

1965

Tahiti

65 Tahiti

IV

GenBank

L11439
aIncludes original identifier for strain, year of isolation, taxa name used in this paper, dengue virus 3 subtype, source of viral sequence, and GenBank accession numbers.

Back to article

Table 3. Nucleotide substitutions conserved within dengue virus 3, subtype III groupsa

Group

Strain

Position

338

429

503

566

653

686

695

707

728

734

749

791

821

866

896

902

978

1010

1019

1056

Reference

H87

A

A

C

G

G

T

T

G

C

C

C

A

T

C

T

T

C

C

T

C

Group A

83SriLan1

-

G

T

A

-

-

C

-

-

T

T

-

-

T

C

C

T

T

-

-

Group A

83SriLan2

-

G

T

A

-

-

C

-

-

T

T

-

-

T

C

C

T

T

-

-

Group A

83SriLan3

-

G

T

A

-

-

C

-

-

-

T

-

-

T

-

C

-

T

-

-

Group A

83SriLan4

-

G

T

A

-

-

C

-

-

T

T

-

-

T

C

C

T

T

-

-

Group A

84SriLan1

-

G

-

-

-

-

-

-

-

-

T

-

-

-

C

-

-

-

-

-

Group A

85SriLan1

-

G

T

A

-

-

C

-

-

T

T

-

-

T

C

C

T

T

-

-

Group A

89SriLan2

-

G

T

A

-

-

C

-

-

T

T

-

-

T

C

C

T

T

-

-

unclassified

84India

G

G

-

-

A

-

-

-

-

-

T

-

-

-

-

-

-

-

G

-

unclassified

93SriLan1

G

G

-

-

A

-

-

-

-

-

-

-

-

-

-

-

-

-

G

-

East Africa

85Mozamb1

G

-

-

-

A

-

-

-

-

-

-

-

-

-

-

-

-

-

G

-

East Africa

85Mozamb2

G

-

-

-

A

-

-

-

-

-

-

-

-

-

-

-

-

-

G

-

East Africa

85Mozamb3

G

-

-

-

A

-

-

-

-

-

-

-

-

-

-

-

-

-

G

-

East Africa

91Kenya

G

-

-

-

A

-

-

-

-

-

-

-

-

-

-

-

-

-

G

-

East Africa

93Somalia

G

-

-

-

A

-

-

-

-

-

-

-

-

-

-

-

-

-

G

Group B

89SriLan1

G

G

-

-

A

-

-

A

T

-

-

-

C

-

-

-

-

-

G

-

Group B

89SriLan3

-

G

-

-

A

-

-

A

T

-

-

-

C

-

-

-

-

-

G

-

Group B

90SriLan1

G

G

-

-

A

-

-

A

T

-

-

-

C

-

-

C

-

-

G

-

Group B

94SriLan1

-

G

-

-

A

-

-

A

T

-

-

-

C

-

-

-

-

-

G

-

Group B

97SriLan1

G

G

-

-

A

-

-

A

T

T

-

-

C

-

C

-

-

-

G

-

Group B

98SriLan1

G

G

-

-

A

-

-

A

T

-

-

-

C

-

C

-

-

-

G

-

L. America

94Nicara1

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

94Panama1

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

94Panama2

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

94Panama3

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

CostaRica1

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

CostaRica2

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

CostaRica3

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

CostaRica4

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

96Mexico1

G

G

-

-

A

C

C

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

96Mexico2

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

96Mexico3

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

96Mexico4

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

97Guatem1

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

98Nicara1

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

98Nicara2

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

98Nicara3

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

98ElSalv1

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

01Venezue1

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

01VEN03

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

98PuertoR1

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T

L. America

00PuertoR1

G

G

-

-

A

C

-

-

-

-

-

G

C

-

-

-

-

-

G

T
aReference strain is the highly passaged laboratory strain H87. Positions are numbered sequentially from the first nucleotide position at the 5¢ end of the genome.

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Comments to the Authors

Please use the form below to submit correspondence to the authors or contact them at the following address:

Aravinda de Silva, Department of Microbiology and Immunology, CB#7290, University of North Carolina, Chapel Hill, NC 27599, USA; fax: (919) 962-8103; email: desilva@med.unc.edu

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This page posted June 11 , 2003
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