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Rubella (German measles)
1996 Case Definition
Clinical case definition
An illness that has all the following characteristics:
- Acute onset of generalized maculopapular rash
- Temperature greater than 99.0 F (greater than 37.2 C), if
measured
- Arthralgia/arthritis, lymphadenopathy, or conjunctivitis
Laboratory criteria for diagnosis
- Isolation of rubella virus, or
- Significant rise between acute- and convalescent-phase titers
in serum rubella immunoglobulin G antibody level by any standard serologic
assay, or
- Positive serologic test for rubella immunoglobulin M (IgM)
antibody
Case classification
Suspected: any generalized rash
illness of acute onset
Probable: a case that meets the clinical case definition,
has no or noncontributory serologic or virologic testing, and is not epidemiologically
linked to a laboratory-confirmed case
Confirmed: a case that is laboratory confirmed or that
meets the clinical case definition and is epidemiologically linked to a laboratory-confirmed
case
Comments
Serum rubella IgM test results that are false positives have
been reported in persons with other viral infections (e.g., acute infection
with Epstein-Barr virus [infectious mononucleosis], recent cytomegalovirus infection,
and parvovirus infection) or in the presence of rheumatoid factor. Patients
who have laboratory evidence of recent measles infection are excluded.
See also:
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