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Rocky Mountain Spotted Fever (Rickettsia
rickettsii) (RMSF)
1990 Case Definition
Clinical description
An illness most commonly characterized by acute
onset and fever, usually accompanied by myalgia, headache, and
petechial rash (on the palms and soles in two-thirds of the cases)
Laboratory criteria for diagnosis
- Fourfold or greater rise in antibody titer
to the spotted fever group antigen by immunofluorescent antibody
(IFA), complement fixation (CF), latex agglutination (LA),
microagglutination (MA), or indirect hemagglutination (IHA)
test, or a single titer greater than or equal to 64 by IFA
or greater than or equal to 16 by CF
- Demonstration of positive immunofluorescence
of skin lesion (biopsy) or organ tissue (autopsy)
- Isolation of Rickettsia rickettsii from
clinical specimen
Case classification
Probable: a clinically
compatible case with supportive serology (fourfold rise in titer
or a single titer greater than or equal to 320 by Proteus OX-19
or OX-2, or a single titer greater than or equal to 128 by LA,
IHA, or MA test)
Confirmed: a case that is laboratory confirmed
See also:
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