| Agent Name |
Cyclohexane |
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| CAS Number |
110-82-7 |
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| Formula |
C6-H12 |
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| Major Category |
Solvents |
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| Synonyms |
Benzene, hexahydro-; Benzenehexahydride; Cicloesano [Italian]; Cyclohexaan [Dutch]; Cyclohexan [German]; Cyclohexane; Cykloheksan [Polish]; Hexahydrobenzene; Hexamethylene; Hexanaphthene; [ChemIDplus] UN1145 |
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| Category |
Aliphatics, Saturated |
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| Description |
Colorless liquid with a sweet, chloroform-like odor; Note: A solid below 44 degrees F; [NIOSH] |
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| Sources/Uses |
Used as a paint remover, solvent for surface coatings, and intermediate for organic synthesis; [ACGIH] |
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| Comments |
Exposed animals develop narcosis and minimal histopathological liver changes. The odor threshold was found to be 25 ppm and 300 ppm by 2 different investigators. [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations may cause CNS effects; [ICSC] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
100 ppm |
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| PEL (OSHA) |
300 ppm |
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| MAK |
200 ppm |
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| IDLH (NIOSH) |
1300 ppm |
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| Excerpts from Documentation for IDLHs |
Basis for original (SCP) IDLH: The chosen IDLH is based on a statement by Patty [1963] that 12,600 ppm produced evidence of lethargy, narcosis, increased respiration rate, and convulsions in animals [Treon et al. 1943]. Also, AIHA [1963] reported that 9,300 ppm for 30 minutes resulted in restlessness, impaired coordination, and exhaustion, but no narcosis or deaths in cats, rabbits, and pigs [Flury and Zernik 1931]. . . . Basis for revised IDLH: Based on health considerations and acute inhalation toxicity data in animals [Lazarew 1929; Treon et al. 1943], a value of about 3,000 ppm would have been appropriate. However, the revised IDLH for cyclohexane is 1,300 ppm based strictly on safety considerations (i.e., being 10% of the lower explosive limit of 1.3%). |
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| Vapor Pressure |
96.9 mm Hg |
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| Odor Threshold Low |
0.52 ppm |
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| Odor Threshold High |
784 ppm |
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| Lethal Concentration |
LCLo (mice) = 70,000 mg/m3/2H |
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| Explanatory Notes |
IDLH = 10% LEL; Detection odor threshold from AIHA (mean = 780 ppm); Flash point = -4 deg F; |
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| Flammability (NFPA) |
3: may ignite at ambient temperature |
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| Adverse Effects |
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| Neurotoxin |
CNS Solvent Syndrome |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: CYCLOHEXANE
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