Volume 8, Number 5, May 2002

Perspective

Evaluation in Nonhuman Primates of Vaccines against Ebola Virus

Thomas W. Geisbert,* Peter Pushko,* Kevin Anderson,* Jonathan Smith,* Kelly J. Davis,* and Peter B. Jahrling*
*U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA 

Figure. Sections of spleen from Ebola virus (EBOV)-infected animals. Top left, BALB/c mouse, note absence of polymerized fibrin (phosphotungstic acid [PTA] hematoxylin, original magnification X400). Field representative of five of five mice tested. Top right: guinea pig. Note discreet foci of polymerized fibrin (arrows) (PTA hematoxylin, original magnification X400). This field shows infrequent fibrin deposits; most fields in five of five animals examined showed no evidence of polymerized fibrin. Lower left: cynomolgus monkey. Note deposition of polymerized fibrin in red pulp (PTA hematoxylin, original magnification X400). Field representative of 25 of 25 monkeys. Lower right: cynomolgus monkey. Electron micrograph showing abundant fibrin deposits in red pulp (original magnification X5,300). Field representative of 11 of 11 monkeys examined.

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This page last reviewed June 21, 2002

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
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