Testing Information

Testing Status of Agents at NTP

Acronycine

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http://ntp.niehs.nih.gov/go/TS-C01536

CASRN: 7008-42-6

Formula: C20 H19 N O3

Synonyms/Common Names:

  • 3,12-DIHYDRO-6-METHOXY-3,3,12-TRIMETHYL-7H-PYRANOL(2,3-C)ACRIDIN-7-ONE (9CI)

Known Uses:

ANTICANCER DRUG

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C01536) Completed 
    • NTIS No. PB283347  (Peer Review 03/07/1978)
      Citation: Bioassay of Acronycine for Possible Carcinogenicity (CAS No. 7008-42-6)
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Intraperitoneal Injection)  (C01536) Completed 
    • NTIS No. PB283347  (Peer Review 03/07/1978)
      Citation: Bioassay of Acronycine for Possible Carcinogenicity (CAS No. 7008-42-6)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: MR: 0,1.5,30, M: 0,2.5,50 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C01536) Report Complete 
    • TR-049 (NTIS No. PB283347)  (Peer Review 03/07/1978)
      Bioassay of Acronycine for Possible Carcinogenicity (CAS No. 7008-42-6)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Inadequate Study 
      • Female Mice Inadequate Study 
    • Dose: R: 0,3.75,7.5,15, M: 0,2,6,12.5,25 MG/KG/35 PER GROUP

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Web page last updated on November 24, 2008