Compounds:   All: 40560   Active: 2052   Inactive: 38420   Unspecified: 100
Substances:   All: 42490   Active: 2300   Inactive: 40085   Unspecified: 105
PubMed: 3 Links

Growth inhibition of the NCI-H23 human Non-Small Cell Lung tumor cell line is measured as a screen for anti-cancer activity. Cells are grown in 96 well plates and exposed to the test compound for 48 hours. Compounds are tested at 5 different concentrations and three endpoints are estimated from this dose response curve: GI50, concentration required for 50% inhibition of growth, TGI, the concentration requires for complete inhibition of growth, and LC50, the concentration required for 50% reduction in cell number. These estimates are done by simple linear interpolation between the concentrations that surround the approriate level. If a compound doesn't cause inhibition to the appropriate level, the endpoint is set to the highest concentration tested.

These data are a subset of the data from the NCI human tumor cell line screen. Compounds are identified by the NCI NSC number. In the NCI numbering system, NCI-H23 is panel number 1, cell number 1
Basically compounds with LogGI50 (unit M) less than -6 were considered as active. Activity score was based on increasing values of -LogGI50.

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