Information on the Elimination of Chlorofluorocarbon-containing (CFC) Albuterol MDIs and Other Ozone-Depleting Drug Products

This web page provides links concerning the elimination of ozone-depleting substances from albuterol Metered-Dose Inhaler (MDI) medications and other communications regarding the removal of CFC-containing metered dose inhaler drugs from the U.S. market.

• Albuterol Transition
• General Information
• Regulatory and Archived Documents

Albuterol Transition

• Press Release (5/30/2008)
• Public Health Advisory (8/28/2008)
• Albuterol Questions & Answers (8/28/2008)
  • English
    • PDF (low resolution, view version)
    • PDF (high resolution, print version)
  • Podcast
  • Full Version
• Spanish
• Albuterol Consumer Article (5/30/2008)
  • English
  • Spanish
• "Important Information For Users Of Albuterol CFC Inhalers" Public Service Announcement (8/28/2008)
  • graphic image-PDF (low resolution, view version)
  • graphic image-PDF (high resolution, print version)
  • text-HTML
• Making the Switch -- Article for Pharmacists about Albuterol Transition (11/2008)
• Letter to Pharmacists about Albuterol Transition (8/29/2008)
• Letter to Schools about Albuterol Transition (6/23/2008)
• Availability of Albuterol Metered Dose Inhalers
• Metered Dose Inhalers: The Transition to Ozone-Safe Propellants (Environmental Protection Agency)

General Information

• Drug Treatments for Asthma and COPD that Do Not Use CFCs
• The Montreal Protocol on Substances that Deplete the Ozone Layer [external link]
• International Pharmaceutical Aerosol Consortium (IPAC). Provides links to resources that discusses upcoming changes to MDIs. [external link]
• Clean Air Act (Environmental Protection Agency)

Regulatory and Archived Documents

• Public Meeting on Essential Uses of Ozone Depleting Substances: Epinephrine MDIs (December 2007)
• Public Meeting on Essential Uses of Ozone Depleting Substances: 7 Marketed "Moieties" (August 2007)
• Final Rule for Removal of Essential-Use Designation for CFC-containing Albuterol (April 2005)
• FDA Talk Paper on the Albuterol Final Rule (March 2005)
• Questions and Answers on Final Rule of Albuterol MDI's (March 2005)
• FDA Regulations Regarding the Use of Chlorofluorocarbons in Metered-Dose Inhalers (March 2005)
• "Your Metered-Dose Inhaler is Changing to Help Improve the Environment" Public Service Announcements (September 2003)
  • One-page version:
    • graphic image-PDF
    • text-HTML
  • Two-page version:
    • graphic image-PDF
    • text-HTML
• FDA Consumer Article (May/June 1997)

Phase-out of epinephrine CFC metered-dose inhalers

• Metered-Dose Inhalers (MDIs)

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Date created: May 30, 2008; updated December 15, 2008

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