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Table 1. Combination Chemotherapy Regimens Commonly Used for Children and Young Adults with Hodgkin Lymphoma
Chemotherapy Regimen
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Corresponding Agents
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ABVD [19] |
doxorubicin (Adriamycin), bleomycin, vinblastine, dacarbazine |
ABVE (DBVE) [14] |
doxorubicin (Adriamycin), bleomycin, vincristine, etoposide |
VAMP [15] |
vincristine, doxorubicin (Adriamycin), methotrexate, prednisone |
OPPA +/- COPP (females) [20] |
vincristine (Oncovin), prednisone, procarbazine, doxorubicin (Adriamycin), cyclophosphamide, vincristine (Oncovin), prednisone, procarbazine |
OEPA +/- COPP (males) [20] |
vincristine (Oncovin), etoposide, prednisone, doxorubicin (Adriamycin), cyclophosphamide, vincristine (Oncovin), prednisone, procarbazine |
COPP/ABV [9] |
cyclophosphamide, vincristine (Oncovin), prednisone, procarbazine, doxorubicin (Adriamycin), bleomycin, vinblastine |
BEACOPP (advanced stage) [21] |
bleomycin, etoposide, doxorubicin (Adriamycin), cyclophosphamide, vincristine (Oncovin), prednisone, procarbazine |
COP(P) (with or without prednisone) |
cyclophosphamide, vincristine (Oncovin), ± prednisone, procarbazine |
CHOP |
cyclophosphamide, doxorubicin (Adriamycin), vincristine (Oncovin), prednisone |
ABVE-PC (DBVE-PC) [22] |
doxorubicin (Adriamycin), bleomycin, vincristine, etoposide, prednisone, cyclophosphamide |
MOPP/ABV [23] |
mechlorethamine, vincristine (Oncovin), procarbazine, prednisone, doxorubicin (Adriamycin), bleomycin, vinblastine |
References
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Nachman JB, Sposto R, Herzog P, et al.: Randomized comparison of low-dose involved-field radiotherapy and no radiotherapy for children with Hodgkin's disease who achieve a complete response to chemotherapy. J Clin Oncol 20 (18): 3765-71, 2002.
[PUBMED Abstract]
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Tebbi CK, Mendenhall N, London WB, et al.: Treatment of stage I, IIA, IIIA1 pediatric Hodgkin disease with doxorubicin, bleomycin, vincristine and etoposide (DBVE) and radiation: a Pediatric Oncology Group (POG) study. Pediatr Blood Cancer 46 (2): 198-202, 2006.
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Donaldson SS, Link MP, Weinstein HJ, et al.: Final results of a prospective clinical trial with VAMP and low-dose involved-field radiation for children with low-risk Hodgkin's disease. J Clin Oncol 25 (3): 332-7, 2007.
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Behrendt H, Brinkhuis M, Van Leeuwen EF: Treatment of childhood Hodgkin's disease with ABVD without radiotherapy. Med Pediatr Oncol 26 (4): 244-8, 1996.
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Rühl U, Albrecht M, Dieckmann K, et al.: Response-adapted radiotherapy in the treatment of pediatric Hodgkin's disease: an interim report at 5 years of the German GPOH-HD 95 trial. Int J Radiat Oncol Biol Phys 51 (5): 1209-18, 2001.
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Kelly KM, Hutchinson RJ, Sposto R, et al.: Feasibility of upfront dose-intensive chemotherapy in children with advanced-stage Hodgkin's lymphoma: preliminary results from the Children's Cancer Group Study CCG-59704. Ann Oncol 13 (Suppl 1): 107-11, 2002.
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Schwartz CL: Special issues in pediatric Hodgkin's disease. Eur J Haematol Suppl (66): 55-62, 2005.
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Chow LM, Nathan PC, Hodgson DC, et al.: Survival and late effects in children with Hodgkin's lymphoma treated with MOPP/ABV and low-dose, extended-field irradiation. J Clin Oncol 24 (36): 5735-41, 2006.
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