Bibliographic Citation
| 6,699,723 | |
| Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes | |
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| 03/02/2004 | |
| US patent application 09/865,130 | |
| Weiss, Shimon (Pinole, CA); Bruchez, Jr., Marcel (Albany, CA); Alivisatos, Paul (Oakland, CA) | |
| Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA | |
| United States Department of Energy | |
| AC03-76SF00098 | |
| The Regents of the University of California (Oakland, CA) | |
| A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation--when excited by an electromagnetic radiation source or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The compound is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. Subsequent exposure to excitation energy will excite the semiconductor nanocrystal in the probe, causing the emission of electromagnetic radiation. Further described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material. | |
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