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Identifying Autism Susceptibility Genes
Release Date: December 13, 2004
Announcement Number: RFA-MH-05-007
Application Receipt Date:
April 19, 2005
Letter of Intent Date: March 19, 2005
Funding Contact: Laura Mamounas, Ph.D.
Program Area: Neurogenetics
Brief Description:
The goal of this Request for Applications (RFA) is to solicit applications to identify specific genes and gene variants in
localized chromosomal regions that confer susceptibility to autism. Fine mapping of disease loci, or quantitative trait loci
(QTLs), is expected to occur in very large datasets of pre-existing samples that have high statistical power for fine mapping
autism susceptibility loci. In order to improve the probability of obtaining biologically and clinically meaningful associations
between genotypes and disease outcomes, this initiative will not be limited to fine-scale mapping of a disease locus but will
proceed to the next level of positional identification of strong candidate genes via assessment of the functional significance
of the autism - associated genetic variants.
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