NINDS Neuroscience Funding Announcements

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Functional Links between the Immune System, Brain Function and Behavior (R21)
Release Date: August 22, 2006
Announcement Number: PA-06-533
Application Receipt Date:
October 16, 2006
February 16, 2007
June 16, 2007
October 16, 2007
February 16, 2008   

Funding Contact: Ursula Utz, Ph.D.
Program Area: Neural Environment
Also See:  http://grants.nih.gov/grants/guide/pa-files/PA-07-088.html

Brief Description:
Despite the brain's status as an immune privileged site, an extensive bi-directional communication takes place between the nervous and the immune system in both health and disease. Immune cells and neuroimmune molecules such as cytokines, chemokines, and growth factors modulate brain function through multiple signaling pathways throughout the lifespan. Immunological, physiological and psychological stressors engage cytokines and other immune molecules as mediators of interactions with neuroendocrine, neuropeptide, and neurotransmitter systems. For example, brain cytokine levels increase following stress exposure, while treatments designed to alleviate stress reverse this effect.

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