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Diagnostic Study of Fludeoxyglucose F 18 Positron Emission Tomography in Staging of Patients With Potentially Operable Carcinoma of the Thoracic Esophagus or Gastroesophageal Junction
Alternate Title Basic Trial Information Objectives Entry Criteria Expected Enrollment Outline Published Results Trial Contact Information Registry Information
Alternate Title
Positron Emission Tomography in Determining Stage of Esophageal Cancer
Basic Trial Information
Phase | Type | Status | Age | Protocol IDs |
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No phase specified | Diagnostic, Treatment | Completed | 18 and over | ACOSOG-Z0060 NCT00004867 |
Objectives - Determine the efficacy of fludeoxyglucose F 18 positron emission tomography imaging in detecting lesions that would preclude esophagectomy in patients with carcinoma of the thoracic esophagus or gastroesophageal junction.
Entry Criteria Disease Characteristics:
- Histologically proven adenocarcinoma or squamous cell carcinoma of the thoracic esophagus (at least 20 cm from incisors) or gastroesophageal
junction
- Stage T1-3, N0-1, M0-1a
- Amenable to curative surgery
- No proximal esophageal cancer (less than 20 cm from
incisors) potentially
requiring pharyngolaryngoesophagectomy
- Regional lymph node involvement allowed
- No unresectable locoregional invasion
- No distant metastatic disease including any or all of the following:
- Positive cytology of the pleura, pericardium, or
peritoneum
- Metastasis to the brain, bone, lung, liver, or adrenals
- Involvement of the tracheobronchial tree (positive
bronchoscopic biopsy or
overt esophagorespiratory fistula)
Prior/Concurrent Therapy:
Biologic therapy: Chemotherapy: - Neoadjuvant chemotherapy or chemoradiotherapy allowed if
administered after fludeoxyglucose F 18 positron emission tomography (PET)
imaging
Endocrine therapy: Radiotherapy: - See Chemotherapy
- Neoadjuvant radiotherapy allowed if administered after
fludeoxyglucose F 18 PET imaging
Surgery: - See Disease Characteristics
Other: - No prior fludeoxyglucose F 18 PET imaging
- Concurrent enrollment in other clinical trials allowed except
those involving fludeoxyglucose F 18 PET imaging
Patient Characteristics:
Age: Performance status: Life expectancy: Hematopoietic: Hepatic: Renal: Other: - No uncontrolled diabetes mellitus (fasting blood glucose
greater than 200mg/dL) within 12 hours prior to PET scan (no diabetic medications within 4 hours prior to checking
blood glucose level)
- Able to fast for at least 4 hours
- Able to tolerate PET imaging
- Not claustrophobic
- Able to lie supine for 1.5 hours
- Not pregnant
- Negative pregnancy test
- No other malignancy within the past 5 years except completely
resected cervical cancer or nonmelanomatous skin cancer and prior
malignancy at low risk of recurrence
- Medically fit for staging procedures or esophagectomy
Expected Enrollment A total of 120-235 patients will be accrued for this study. Outline This is a multicenter study. Patients receive fludeoxyglucose F 18 (FDG) IV followed 45-60 minutes
later by positron emission tomography (PET) imaging. Confirmatory studies,
such as biopsy or other imaging studies, are then conducted to confirm the FDG
PET imaging results. Patients with no metastases identified by FDG PET
imaging may undergo esophagectomy with or without neoadjuvant
chemoradiotherapy within 1 month of evaluation. Patients are followed within 6 months after surgery. Published ResultsVeeramachaneni NK, Zoole JB, Decker PA, et al.: Lymph node analysis in esophageal resection: American College of Surgeons Oncology Group Z0060 trial. Ann Thorac Surg 86 (2): 418-21; discussion 421, 2008.[PUBMED Abstract]
Trial Contact Information
Trial Lead Organizations American College of Surgeons Oncology Group | | | Bryan Meyers, MD, MPH, Protocol chair | | Ph: 314-362-8598; 800-600-3606 |
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Registry Information | | Official Title | | The Utility of Positron Emission Tomography (PET) in Staging of Patients with Potentially Operable Carcinoma of the Thoracic Esophagus | | Trial Start Date | | 1999-11-22 | | Trial Completion Date | | 2009-01-16 | | Registered in ClinicalTrials.gov | | NCT00004867 | | Date Submitted to PDQ | | 2000-01-05 | | Information Last Verified | | 2005-04-26 | | NCI Grant/Contract Number | | CA76001 |
Note: The purpose of most clinical trials listed in this database is to test new cancer treatments, or new methods of diagnosing, screening, or preventing cancer. Because all potentially harmful side effects are not known before a trial is conducted, dose and schedule modifications may be required for participants if they develop side effects from the treatment or test. The therapy or test described in this clinical trial is intended for use by clinical oncologists in carefully structured settings, and may not prove to be more effective than standard treatment. A responsible investigator associated with this clinical trial should be consulted before using this protocol. Back to Top |
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