U. S. Food and Drug Administration
Center for Food Safety and Applied Nutrition
October 15, 2002


FDA Workshop on the Notification Process for Food Contact Substances

Chemistry and Structure Activity Relationships (SAR) Analysis

October 15, 2002


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Author: Nancy C. Braier


Table of Contents

  1. Chemistry and Structure Activity Relationships (SAR) Analysis.....Nancy Collazo-Braier, Ph. D..SAR Team.
  2. Chemistry and SAR Analysis. .A SAR analysis begins with a representative chemical structure structure.
  3. SAR in the FCN Process. .Phase 1 : SAR complements available data
  4. Databases Searches..Sample Database Tool: TOXSYS
  5. SAR in the FCN Process.. Phase 2: Theoretical Risk Analysis.
  6. Determination of a Suitable Analog.
  7. Example.2-Ethylhexyl acrylate (2-EHA)
  8. Example: 2-EHA.Search results
  9. Example: 2-EHA.Phthalate-like
  10. Example: 2-EHA.Phthalate-like-(cont.)
  11. Example: 2-EHA.Acrylate-like
  12. Example: 2-EHA.Conclusions

FCN Workshop Agenda & Presentations

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