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Stage I Uterine Sarcoma
Current Clinical Trials
Standard treatment options:
- Surgery (total abdominal hysterectomy, bilateral salpingo-oophorectomy, and
pelvic and periaortic selective lymphadenectomy).
- Surgery plus pelvic radiation therapy.
- Surgery plus adjuvant chemotherapy.
- Surgery plus adjuvant radiation therapy as seen in the EORTC-55874 trial, for example.
In a nonrandomized Gynecologic Oncology Group study in patients with stage I
and II carcinosarcomas, those who had pelvic radiation therapy had a significant
reduction of recurrences within the radiation treatment field but no alteration
in survival.[1] A large nonrandomized study demonstrated improved survival and
a lower local failure rate in patients with mixed mullerian tumors following
postoperative external and intracavitary radiation therapy.[2] One
nonrandomized study that predominantly included patients with carcinosarcomas appeared to show benefit for adjuvant therapy with cisplatin
and doxorubicin.[3]
Current Clinical Trials
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage I uterine sarcoma. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
References
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Hornback NB, Omura G, Major FJ: Observations on the use of adjuvant radiation therapy in patients with stage I and II uterine sarcoma. Int J Radiat Oncol Biol Phys 12 (12): 2127-30, 1986.
[PUBMED Abstract]
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Larson B, Silfverswärd C, Nilsson B, et al.: Mixed müllerian tumours of the uterus--prognostic factors: a clinical and histopathologic study of 147 cases. Radiother Oncol 17 (2): 123-32, 1990.
[PUBMED Abstract]
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Peters WA 3rd, Rivkin SE, Smith MR, et al.: Cisplatin and adriamycin combination chemotherapy for uterine stromal sarcomas and mixed mesodermal tumors. Gynecol Oncol 34 (3): 323-7, 1989.
[PUBMED Abstract]
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