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Nonmetastatic Gestational Trophoblastic Tumors
Current Clinical Trials
This is the most common presentation of gestational trophoblastic tumors and usually requires treatment with
cytotoxic therapy, primarily single agents.
Standard treatment options:
Treatment usually consists of single-agent chemotherapy though hysterectomy
has been used in the occasional patient where preservation of reproductive
function is not an issue. Single-agent chemotherapy is usually methotrexate
unless the patient has abnormal liver function, in which case dactinomycin is
used.
- Methotrexate with leucovorin.[1]
- Dactinomycin.[2]
Other regimens appear to produce similar survival outcomes but have been
studied less extensively or are in less common use. They are:
- Methotrexate.[2-4]
- Etoposide.[5]
Current Clinical Trials
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with nonmetastatic gestational trophoblastic tumor. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
References
-
Berkowitz RS, Goldstein DP, Bernstein MR: Ten year's experience with methotrexate and folinic acid as primary therapy for gestational trophoblastic disease. Gynecol Oncol 23 (1): 111-8, 1986.
[PUBMED Abstract]
-
Tumors of the placental trophoblast. In: Morrow CP, Curtin JP: Synopsis of Gynecologic Oncology. 5th ed. New York, NY: Churchill Livingstone, 1998, pp 315-353.
-
Homesley HD, Blessing JA, Rettenmaier M, et al.: Weekly intramuscular methotrexate for nonmetastatic gestational trophoblastic disease. Obstet Gynecol 72 (3 Pt 1): 413-8, 1988.
[PUBMED Abstract]
-
Homesley HD, Blessing JA, Schlaerth J, et al.: Rapid escalation of weekly intramuscular methotrexate for nonmetastatic gestational trophoblastic disease: a Gynecologic Oncology Group study. Gynecol Oncol 39 (3): 305-8, 1990.
[PUBMED Abstract]
-
Wong LC, Choo YC, Ma HK: Primary oral etoposide therapy in gestational trophoblastic disease. An update. Cancer 58 (1): 14-7, 1986.
[PUBMED Abstract]
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