• Head and Neck Cancer Disease Site Group. Mackenzie RG, Hodson DI, Browman GP, Zuraw L. Hyperfractionated radiotherapy for locally advanced squamous cell carcinoma of the head and neck [full report]. Toronto (ON): Cancer Care Ontario (CCO); 2003 Jan [online update]. 13 p. (Practice guideline report; no. 5-6b). [22 references]

• This group of patients should be considered for concomitant chemotherapy and conventional radiation as recommended in Cancer Care Ontario Practice Guidelines Initiative Guideline No. 5-6a titled "Concomitant Chemotherapy and Radiotherapy in Squamous Cell Head and Neck Cancer (Excluding Nasopharynx)."
• Hyperfractionated radiotherapy cannot be recommended as routine clinical practice at this time.

None provided

Seven randomized controlled trials (two reported in abstract form) of hyperfractionated radiotherapy compared with conventional radiotherapy met the inclusion criteria. The results of a published meta-analysis of randomized controlled trials of hyperfractionated radiotherapy are also included in the original guideline document. In addition, limited evidence from two meeting abstracts and one published report (an additional randomized trial) have been included in the update.

• Head and Neck Cancer Disease Site Group. Mackenzie RG, Hodson DI, Browman GP, Zuraw L. Hyperfractionated radiotherapy for locally advanced squamous cell carcinoma of the head and neck [full report]. Toronto (ON): Cancer Care Ontario (CCO); 2003 Jan [online update]. 13 p. (Practice guideline report; no. 5-6b). [22 references]

Not applicable: The guideline was not adapted from another source.

2000 Nov 27 (revised online 2003 Jan)

Program in Evidence-based Care - State/Local Government Agency [Non-U.S.]

The Practice Guidelines Initiative (PGI) is the main project of the Program in Evidence-based Care (PEBC), a Province of Ontario initiative sponsored by Cancer Care Ontario and the Ontario Ministry of Health and Long-Term Care.

Cancer Care Ontario, Ontario Ministry of Health Long-Term Care

Provincial Head and Neck Cancer Disease Site Group

Members of the Head and Neck Cancer Disease Site Group disclosed potential conflict of interest information.

None available

This summary was completed by ECRI on June 5, 2002. The information was verified by the guideline developer as of July 8, 2002. This summary was updated by ECRI on June 23, 2003. The updated information was verified by the guideline developer on July 16, 2003.