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U.S. National Institutes of Health National Cancer Institute
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Islet Cell Tumors (Endocrine Pancreas) Treatment (PDQ®)     
Last Modified: 10/31/2008
Health Professional Version
Cellular Classification



Endocrine Tumors of the Pancreas
Islet cells  Secreted active agent  Tumor and syndrome 
Alpha Glucagon Glucagonoma (diabetes, dermatitis)
Beta Insulin Insulinoma (hypoglycemia)
Delta Somatostatin Somatostatinoma (mild diabetes)
D Gastrin Gastrinoma (peptic ulcer disease)
A -> D Vasoactive Intestinal Peptide (VIP) and/or other undefined mediators WDHA (watery diarrhea, hypokalemia, achlorhydria)
serotonin (5-HT) Carcinoid
ACTH Cushing disease
MSH Hyperpigmentation
Interacinar cells Secreted active agent Tumor and syndrome
F Pancreatic polypeptide Multiple hormonal syndromes
EC 5-HT Carcinoid



Table of Links

1http://www.cancer.gov/cancertopics/pdq/treatment/isletcell/HealthProfessional/T
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