CURRICULUM VITAE

Blood Products Advisory Committee

Andrea Beth Troxel, Sc.D.

Office Address: Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania, School of Medicine
632 Blockley Hall, 423 Guardian Drive
Philadelphia, Pennsylvania 19104-6021
Telephone: (215) 573-0659
FAX: (215) 573-4865
E-mail: atroxel@mail.med.upenn.edu

Education:

------- B.S. Yale University (Applied Mathematics) cum laude
------- Sc.D. Harvard School of Public Health (Biostatistics)

Postgraduate Training and Fellowship Appointments:

1995 – 1997 Postdoctoral Fellow and Statistical Research Associate, Southwest Oncology Group, Fred Hutchinson Cancer Research Center, Seattle, Washington

Military Service: None

Faculty Appointments:

2003 – 2006 Assistant Professor of Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA
2006 – present Associate Professor of Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA.

Hospital and Administrative Appointments:

2003 – present Senior Scholar, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine
2003 – present Member, Epidemiology and Biostatistics Graduate Group, Biomedical Graduate Studies, University of Pennsylvania School of Medicine

Other Appointments:

1997 – 2000 Assistant Professor of Clinical Public Health, Herbert Irving Comprehensive Cancer Center, Division of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY
2000 – 2003 Assistant Professor of Biostatistics, Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY

Specialty Certification: n/a

Licensure: n/a

Awards, Honors and Membership in Honorary Societies:

1991 – 1993 National Institutes of Health Training Grant
1992 – 1994 Harvard University Teaching Fellow
2002 – present Sigma Xi

Membership in Professional and Scientific Societies and Other Professional Activities:

International:

1999 – present International Biometrics Society

National:

1996 Member, Workshop on Missing Data in Quality of Life Research in Cancer Clinical Trials: Practical and Methodological Issues, Swiss Group for Clinical Cancer Research.
1997 Member, Phase II Clinical Trials of New Chemopreventive Agents, NIH Review Panel and Board, NCI
1999 – present Member, American Statistical Association
2001 Member, Minimally Invasive Surgical Therapies for Benign Prostatic Hypertrophy, NIH Review Panel and Board, NIDDK
2002 – 2004 Member, Chronic Prostatitis Collaborative Research Network (CPCRN), External Advisory Committee, NIDDK
2003 Member, Avon/NCI Progress for Patients Award Program
2005 – 2006 Ad hoc member, Biostatistical Methods and Research Design study section, Health of Populations IRG, NIH
2005 Ad hoc member, Developmental Therapeutics study section, Oncological Sciences IRG, NIH
2005 Ad hoc member, Subcommittee E (Cancer Epidemiology, Prevention and Control), National Cancer Institute IRG, NIH
2005 – present Ad hoc member, Epidemiology of Cancer study section, Health of Populations IRG, NIH
2007 – present Chair, Data and Safety Monitoring Board, DAIDS-ES 10401 (Antiviral Activity of Peg-IFN-a-2A in Chronic HIV-1 Infection; L Montaner, PI)
2008 – present Member, Blood Products Advisory Committee, Food and Drug Administration

Local:

2004 – present Member, Data and Safety Monitoring Board, UPCC 11102/03104
2004 – present Member, Philadelphia Chapter, American Statistical Association

Editorial Positions:

1998 – present Reviewer Applied Statistics
1998 – present Reviewer Biometrics
1998 – present Reviewer Journal of the American Medical Women’s Association
1998 – present Reviewer Journal of Clinical Oncology
1998 – present Reviewer Journal of the American Statistical Association
1999 – present Reviewer American Journal of Public Health
1999 – present Reviewer Quality of Life Research
1999 – present Reviewer Statistics in Medicine
2000 – present Reviewer Communication in Statistics
2000 – present Reviewer Controlled Clinical Trials
2002 – present Reviewer Biometrical Journal
2005 – present Reviewer Fertility and Sterility
2005 – present Associate Editor Statistics in Medicine
2006 – present Reviewer Journal of the National Cancer Institute
2006 – present Reviewer Scandinavian Journal of Statistics
2007 – present Reviewer Journal of Clinical Investigation
2007 – present Reviewer Journal of Biopharmaceutical Statistics
2007 – present Reviewer Pharmacoepidemiology and Drug Safety
2008 – present Reviewer Journal of the Royal Statistical Society, Series B

Academic and Institutional Committees:

2003 – present Member, Admissions Committee, Division of Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2004 – 2006 Member (Chair, 2005-2006) , Curriculum Committee, Division of Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2004 – present Member, Appointments Committee, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine
2005 Member, Summer Fellowship Committee, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine
2006 – present Chair, Qualifying Examination Committee, Division of Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2006 – present Member, Committee on Appointments and Promotions (COAP), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2006 – present Member, Gender Equity Council, University of Pennsylvania School of Medicine

Major Academic and Clinical Teaching Responsibilities:

2003 – 2006 PhD Thesis Committee Member for ---------------- Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2003 – 2006 PhD Thesis Director for ------------------------ Columbia University Mailman School of Public Health
Spring 2004 Instructor, Consulting II (BSTA 691), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
Fall 2004 Course Director, Applied Regression Models for Categorical Data (EP622), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
Fall 2004 Course Director, Independent Study: Applied Regression Models for Categorical Data (EP999), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
Fall 2004 Lecturer, Unequal Treatment: Health in America (HSOC 015), Health and Societies Program, University of Pennsylvania School of Arts and Sciences
Fall 2004 Lecturer, Independent Study: Ameliorating Health Disparities One Step at a Time (HSOC 499.036), Health and Societies Program, University of Pennsylvania School of Arts and Sciences
2004 – 2006 MSCE Thesis Committee Member for -------------------- MD, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2004 – 2006 MSCE Thesis Committee Member for -------------------- MD, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2004 – 2005 MSCE Thesis Committee Member for --------------------- MD, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2004 – 2008 MSCE Thesis Committee Member for ---------------------- MD, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
Spring 2005 Lecturer, Independent Study: Ameliorating Health Disparities One Step at a Time (HSOC 499.036), Health and Societies Program, University of Pennsylvania School of Arts and Sciences
Spring 2005 Lecturer, Undergraduate Urban Research Course (CPLN 528/URBS 428), Institute for Urban Research, University of Pennsylvania School of Arts and Sciences
Spring 2005 Instructor, Consulting II (BSTA 691), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
Spring 2005 Facilitator, BGS Bioethics Workshop for 3 rd Year Students, University of Pennsylvania School of Medicine
Fall 2005 Course Director, Applied Regression Models for Categorical Data (EP622), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2005 – present MSCE Thesis Committee Member for ------------------- MD, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
Spring 2006 Course Director, Independent Study: Longitudinal Data Analysis (EP999), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
Fall 2006 Course Director, Applied Regression Models for Categorical Data (EP622), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2006 – present MSCE Thesis Committee Member for ---------------------- MD, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2006 – present MSCE Thesis Committee Member for --------------------- MD, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2006 – present MSCE Thesis Committee Member for ------------------- MD, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2006 – present MSCE Thesis Committee Member for -------------------- MD, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2006 – present Secondary Mentor, ---------------------------- ScD, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
Spring 2007 Lecturer, Clinical Trials (EP630), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
Spring 2007 Lecturer, Fundamentals of Pharmacology II (Pharm623), Department of Pharmacology, University of Pennsylvania School of Medicine
Summer 2007 Lecturer, Advanced Topics in Clinical Epidemiology (EP 640), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2007 – present Primary Mentor, ------------------------- PhD, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2007 – present MSCE Thesis Committee Member for -------------------- MD, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2007 – present MSCE Thesis Committee Member for -------------------- MD, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
Fall 2007 Course Director, Applied Regression Models for Categorical Data (EP622), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
Fall 2007 Course Director, Applied Survival Analysis (EP623), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
2008 – present PhD Thesis Committee Member for ----------------- Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
Spring 2008 Lecturer, Clinical Trials (EP630), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine
Spring 2008 Lecturer, Fundamentals of Pharmacology II (Pharm623), Department of Pharmacology, University of Pennsylvania School of Medicine
Summer 2008 Lecturer, Advanced Topics in Clinical Epidemiology (EP 640), Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine

Lectures by invitation: (past five years only)

7/25/2002 “Measuring Sensitivity to Nonignorability” – International Biometrics Conference, Freiburg, Germany
8/12/2002 “Measuring Sensitivity to Nonignorability” – American Statistical Association Joint Statistical Meetings, New York, NY
2/13/2003 “Measuring Sensitivity to Nonignorability” – Department of Environmental Medicine, New York University, New York, NY
4/22/2003 “Measuring Sensitivity to Nonignorability” – Department of Biostatistics and Epidemiology, University of Pennsylvania, School of Medicine, Philadelphia, PA
11/11/2003 “Measuring Sensitivity to Nonignorability” – Division of Biostatistics, School of Epidemiology and Public Health, Yale University, New Haven, CT
12/16/2004 “Modeling Quality of Life Data with Missing Values” – Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA
1/13/2005 “Modeling Quality of Life data with Missing Values” – Clinical Epidemiology and Risk Reduction Program, Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA.
2/28/2005 “Frailty Models for Quality of Life Data in Oncology” – Fred Hutchinson Cancer Research Center, Seattle, WA
3/2/2005 “Modeling Quality of Life Data with Missing Values” – Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD
3/5/2005 “Modeling Quality of Life Data with Missing Values” – Connecticut Chapter of the American Statistical Association, Wallingford, CT
6/2/2005 “Epidemiologic Field Research – Opportunities and Challenges” – Department of Family Practice and Community Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA
8/9/2005 “Frailty Models for Quality of Life Data in Oncology” – Joint Statistical Meetings, Minneapolis, MN
7/29/2007 “Multivariate Normal Frailty Models for Multiple QOL Outcomes” – Joint Statistical Meetings, Salt Lake City, UT

Organizing roles in Scientific Meetings:

3/1999 ENAR meeting, Organized Invited Session 45, “New Developments in Analysis of Quality of Life in Clinical Trials”, Atlanta, GA.
8/14/2002 JSM, Organized Invited Session 340, “Sensitivity Analysis for Longitudinal Data”, New York, NY.
8/9/2005 JSM, Organized Topic Contributed Session 309, “Analyzing Quality of Life Data in Clinical Trials”, Minneapolis, MN.

Bibliography:

Research publications, peer reviewed:

  1. Gribben J.G., Neuberg D., Freedman A.S., Pesek K., Troxel A.B., and Nadler L.M.: Detection of residual Lymphoma Cells by PCR in Peripheral Blood is significantly Less Predictive for Relapse than Evaluation of Bone Marrow. Blood. 80:337, 1992
  2. Saphner, T., Troxel, A.B., Tormey, D.C., Neuberg, D., Robert, N.J., Pandya, K.J., Edmonson, J.H., Rosenbluth, R.J. and Abeloff, M.D. Phase II study of goserelin for patients with postmenopausal metastatic breast cancer. Journal of Clinical Oncology, 11: 1529-35, 1993.
  3. Bennett, J.M., Troxel, A.B., Gelman, R., Falkson, G., Coccia-Portugal, M.D., Dreicer, R., Tormey, D.C. and Rushing, D. Myelodysplastic syndrome and acute myeloid leukemia secondary to mitolactol treatment in patients with breast cancer. Journal of Clinical Oncology, 12: 874-5, 1994.
  4. Ramsey, S.D., Etzioni, R., Troxel, A.B. and Urban, N. Optimizing sampling strategies for estimating quality-adjusted life years. Medical Decision Making, 17: 431-8, 1997.
  5. Troxel, A.B., Lipsitz, S.R. and Brennan, T.A. Weighted estimating equations with nonignorably missing response data. Biometrics, 53: 857-69, 1997.
  6. Moinpour, C.M., Savage, M.J., Troxel, A.B., Lovato, L.C., Eisenberger, M., Veith, R.B., Higgins, B., Skeel, R., Yee, M., Blumenstein, B., Crawford, E.D. and Meyskens, F.L. Quality of life in advanced prostate cancer: results of a randomized therapeutic trial. Journal of the National Cancer Institute, 90: 1537-44, 1998.
  7. Troxel, A.B. A comparative analysis of quality of life data from a Southwest Oncology Group randomized trial of advanced colorectal cancer. Statistics in Medicine, 17: 767-79, 1998.
  8. Troxel, A.B., Fairclough, D.L., Curran, D. and Hahn, E.A. Statistical analysis of quality of life with missing data in cancer clinical trials. Statistics in Medicine, 17: 653-66, 1998.
  9. Troxel, A.B., Harrington, D.P. and Lipsitz, S.R. Analysis of longitudinal data with non-ignorable non-monotone missing values. Applied Statistics, 74: 425-38, 1998.
  10. Troxel, A.B., Lipsitz, S.R. and Harrington, D.P. Marginal models for the analysis of longitudinal measurements with nonignorable non-monotone missing data. Biometrika, 85: 661-72, 1998.
  11. Grann, V.R., Jacobson, J.S., Sundararajan, V., Albert, S.M., Troxel, A.B. and Neugut, A.I. The quality of life associated with prophylactic treatment for women with BRCA1/2 mutations. Cancer Journal from Scientific American, 5: 283-92, 1999.
  12. Kambham, N., Taylor, J.A., Troxel, A.B. and Rubin, M.A. Atypical small acinar proliferation in prostate needle biopsies: a clinically significant category. Journal of Urologic Pathology, 10: 177-87, 1999.
  13. Papadopoulos, K.P., Ayello, J., Reiss, R.F., Troxel, A., Kaufman, E., Vahdat, L.T., Antman, K.H. and Hesdorffer, C.S. CD34+ cell dose requirements for rapid engraftment in a sequential high dose chemotherapy regimen of paclitaxel, melphalan and cyclophosphamide, thiotepa, and carboplatin (CTCb) with PBPC support in metastatic breast cancer. Journal of Hematotherapy and Stem Cell Research, 8: 357-63, 1999.
  14. Papadopoulos, K.P., Balmaceda, C., Fetell, M., Kaufman, E., Vahdat, L.T., Bruce, J., Sisti, M., Isaacson, S., DeLaPaz, R., Savage, D.G., Troxel, A., Antman, K.H. and Hesdorffer, C.S. A phase I study of BCNU, etoposide, and escalating-dose thiotepa (BTE) with hematopoietic progenitor cell support in adults with recurrent and high-risk brain tumors. Journal of Neurooncology, 44: 155-62, 1999.
  15. Rowe, D.R., Huang, J., Kayton, M.L., Thompson, R., Troxel, A., O’Toole, K.M., Yamashiro, D., Stolar, C.J.H. and Kandel, J. Anti-VEGF antibody suppresses primary tumor growth and metastasis in an experimental model of Wilms’ tumor. Journal of Pediatric Surgery, 35: 30-3, 2000.
  16. Brenin, D.R., Manasseh, D.M., El-Tamer, M., Troxel, A., Schnabel, F., Ditkoff, B.A. and Kinne, D. Factors correlating with lymph node metastases in patients with T1 breast cancer. Annals of Surgical Oncology, 8: 432-7, 2001.
  17. Jacobson, J.S., Troxel, A.B., Evans, J., Klaus, L., Vahdat, L.T., Kinne, D., Lo, K.M., Moore, A., Rosenman, P.J., Kaufman, E.L., Neugut, A.I. and Grann, V.R. Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. Journal of Clinical Oncology, 19: 2739-45, 2001.
  18. Ovchinnikov, I., Troxel, A.B. and Swergold, G.D. Genomic characterization of recent human LINE-1 insertions: evidence supporting random insertion. Genome Research, 11: 2050-8, 2001.
  19. Papadopoulos, K.P., Egorin, M.J., Huang, M., Troxel, A.B., Kaufman, E., Balmaceda, C.M., Vahdat, L.T. and Hesdorffer, C.S. The pharmacokinetics and pharmacodynamics of high-dose paclitaxel monotherapy (825 mg/m2 continuous infusion over 24h) with hematopoietic support in women with metastatic breast cancer. Cancer Chemotherapy Pharmacology, 47: 45-60, 2001.
  20. Nichols, G., de Castro, K., Wei, L.X., Griffin, M., Lin, M., Oratzi, A., Murty, A.V.V.S., Troxel, A., Vahdat, L. and Hesdorffer, C. Therapy-related myelodysplastic syndrome after autologous stem cell transplantation for breast cancer. Leukemia, 16: 1673-9, 2002.
    21. Troxel, A.B. Techniques for incorporating longitudinal measurements into analyses of survival data from clinical trials. Statistical Methods in Medical Research, 11: 237-45, 2002
  21. Vahdat, LT., Balmaceda, C., Papadopoulos, K., Frederick, D., Donovan, D., Sharpe, E., Kaufman, E., Savage, D., Tiersten, A., Nichols, G., Haythe, J., Troxel, A., Antman, K. and Hesdorffer, C.S. Phase II trial of sequential high-dose chemotherapy with paclitaxel, melphalan and cyclophosphamide, thiotepa and carboplatin with peripheral blood progenitor support in women with responding metastatic breast cancer. Bone Marrow Transplantation. 30: 149-55, 2002. -
  22. El-Tamer, M., Komenaka, I., Curry, S., Troxel, A.B., Ditkoff, B.A. and Schnabel, F.R. Pulse oximeter changes with sentinel lymph node biopsy in breast cancer. Archives of Surgery, 138: 1257-60, 2003.
  23. Hershman, D., Weinberg, M., Rosner, Z., Alexis, K., Tiersten, A., Grann, V.R., Troxel, A. and Neugut, AI. Ethnic neutropenia and treatment delay in African American women undergoing chemotherapy for early-stage breast cancer. Journal of the National Cancer Institute, 95: 1545-8, 2003.
  24. Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A.B., Rosen, J., Eskelinen, E.L., Mizushima, N., Ohsumi, Y., Cattoretti, G. and Levine, B. Promotion of tumorigenesis by heterozygous disruption of the beclin1 autophagy gene. Journal of Clinical Investigation, 11: 1809-20, 2003.
  25. Talbot, S.M., Keohan, M.L., Hesdorffer, M., Orrico, R., Bagiella, E., Troxel, A.B. and Taub, R.N. A Phase II trial of temozolomide in patients with unresectable or metastatic soft tissue sarcoma. Cancer, 98: 1942-6, 2003.
  26. Tiersten, A.D., Nelson, C., Talbot, S., Vahdat, L., Fine, R., Troxel, A., Brafman, L., Shriberg, L., Antman, K. and Petrylak, D.P. A phase II trial of docetaxel and estramustine in patients with refractory metastatic breast carcinoma. Cancer, 97: 537-44, 2003.
  27. El-Tamer, M.B., Komenaka, I.K., Troxel, A., Li, H., Joseph, K.A., Ditkoff, B.A., Schnabel, F.R. and Kinne, D.W. Men with breast cancer have better disease-specific survival than women. Archives of Surgery, 139: 1079-82, 2004.
  28. El-Tamer, M., Russo, D., Troxel, A., Bernadino, L.P., Mazziotta, R., Estabrook, A., Ditkoff, B.A., Schnabel, F.R. and Mansukhani, M. Survival and recurrence after breast cancer in BRCA 1/2 mutation carriers. Annals of Surgical Oncology, 11: 157-64, 2004.
  29. Joseph, K.A., El-Tamer, M., Komenaka, I., Troxel, A., Ditkoff, B.A. and Schnabel, F. Predictors of nonsentinel node metastasis in patients with breast cancer after sentinel node metastasis. Archives of Surgery. 139: 648-51, 2004.
  30. Komenaka, S.K., El-Tamer, M.B., Troxel, A., Hamele-Bena, D., Joseph, K.A., Horowitz, E., Ditkoff, B.A. and Schnabel, F.R. Pure mucinous carcinoma of the breast. American Journal of Surgery, 187: 528-32, 2004.
  31. Tiersten, A., Ng, Y.Y., Pile-Spellman, E., Nelsen, C., Noguera-Irizarry, W., Brafman, R., Russo, D., Troxel, A. and Johnson, A. Relationship between mammographic breast density and tamoxifen in women with breast cancer. Breast Journal, 10: 313-17, 2004.
  32. Tiersten, A.D., Selleck, M.J., Hershman, D.L., Smith, D., Resnik, E.E., Troxel, A.B., Brafman, L.B. and Shriberg, L. Phase II study of topotecan and paclitaxel for recurrent, persistent or metastatic cervical carcinoma. Gynecologic Oncology, 92: 635-8, 2004.
  33. Tiersten, A., Wo, J., Jacobson, C., Weitzman, A., Horwich, T., Hesdorffer, C., Savage, D. and Troxel, A. Cardiac toxicity observed in association with high-dose cyclophosphamide-based chemotherapy for metastatic breast cancer. Breast. 13: 341-6, 2004.
  34. Troxel, A.B. and Esserman, D.A. Frailty models for quality of life in oncology. Journal of Biopharmaceutical Statistics, 14: 145-54, 2004.
  35. Troxel, A.B., Ma, G. and Heitjan, D.F. An index of local sensitivity to nonignorability. Statistica Sinica, 14: 1221-37, 2004.
  36. Grann, V.R., Jacobson, J.S., Troxel, A.B., Hershman, D., Karp, J., Myers, K. and Neugut, A.I. Barriers to minority participation in breast cancer prevention trials. Cancer, 104: 374-9, 2005.
  37. Grann, V.R., Troxel, A.B., Zojwalla, N., Jacobson, J.S., Hershman, D. and Neugut, A.I. Hormone receptor status and survival in a population-based cohort of patients with breast carcinoma. Cancer, 103: 2241-51, 2005.
  38. Joe, A.K., Memeo, L., McKoy, J., Mansukhani, M., Liu, H., Avila-Bront, A., Romero, J., Li, H., Troxel, A. and Hibshoosh, H. Cyclin D1 overexpression is associated with estrogen receptor expression in Caucasian but not African-American breast cancer. Anticancer Research, 25: 273-81, 2005.
  39. Ma, G., Troxel, A.B. and Heitjan, D.F. An index of local sensitivity to nonignorable dropout in longitudinal modeling. Statistics in Medicine, 24: 2129-50, 2005.
  40. Park, J-H., Gopishetty, S., Szewczuk, L.M., Troxel, A.B., Harvey, R.G. and Penning, T.M. Formation of 8-oxo-7, 8-dihydro-2’-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling. Chemical Research in Toxicology, 18:1026-37, 2005.
  41. Stettler, N., Stallings,V.A., Troxel, A.B., Zhao, J., Schinnar, R., Nelson, S.E., Ziegler, E. E. and Strom, B.L. Weight gain in the first week of life and overweight in adulthood: a cohort study of European-American subjects fed infant formula. Circulation, 111: 1897-903, 2005.
  42. Stubblefield, M.D., Vahdat, L.T., Balmaceda, C.M., Troxel, A.B., Hesdorffer, C.S. and Gooch, C.L. Glutamine as a neuroprotective agent in high-dose paclitaxel-induced peripheral neuropathy: a clinical and electrophysiologic study. Clinical Oncology, 17: 271-6, 2005.
  43. Brown, T.T., Quain, R.D., Troxel, A.B. and Gelfand, J.M. The epidemiology of sunburn in the U.S. population in 2003. Journal of the American Academy of Dermatology, 55: 577-83, 2006.
  44. Clark, J., Lambertson, C., Gelfand, R. and Troxel, A. Optimization of oxygen tolerance extension in rats by intermittent exposure. Journal of Applied Physiology, 100: 869-79, 2006.
  45. Fisher, J.A., Fikry, C.F. and Troxel, A.B. Cutting cost and increasing access to colorectal cancer screening: another approach to following the guidelines. Cancer Epidemiology, Biomarkers and Prevention, 15: 108-13, 2006.
  46. Gelfand, J.M., Neimann, A.L., Shin, D.B., Wang, X., Margolis, D.J. and Troxel, A.B. The risk of myocardial infarction in patients with psoriasis. Journal of the American Medical Association, 296: 1735-41, 2006.
  47. Gelfand, J.M., Shin, D.B., Neimann, A.L., Wang, X., Margolis, D.J. and Troxel, A.B. The risk of lymphoma in patients with psoriasis. Journal of Investigative Dermatology, 126: 2194-201, 2006.
  48. Gorin, S.S., Ashford, A.R., Lantigua, R., Hossain, A., Desai, M., Troxel, A. and Gemson, D. Effectiveness of academic detailing on breast cancer screening among primary care physicians in an underserved community. Journal of the American Board of Family Medicine, 19: 110-21, 2006.
  49. Grann, V.R., Troxel, A.B., Zojwalla, N., Hershman, D., Glied, S.A. and Jacobson, J.S. Regional and racial disparities in breast cancer-specific mortality. Social Science and Medicine, 62: 337-47, 2006.
  50. Jacobson, J.S., Grann, V.R., Hershman, D., Troxel, A.B., Li, H. and Neugut, A.I. Breast biopsy and race/ethnicity among women without breast cancer. Cancer Detection and Prevention, 30: 129-33, 2006.
  51. Ma, G., Troxel, A.B. and Heitjan, D.F. Author’s reply. Statistics in Medicine, 25: 3218-20, 2006.
  52. Neimann, A.N., Shin, D.B., Wang, X., Margollis, D.J., Troxel, A.B., and Gelfand, J.M. Prevalence of cardiovascular risk factors in patients with psoriasis. Journal of the American Academy of Dermatology, 55: 829-35, 2006.
  53. Ochroch, E.A., Gottschalk, A., Troxel, A.B. and Farrar, J.T. Women suffer more short and longterm pain than men after major thoracotomy. Clinical Journal of Pain, 22: 491-8, 2006.
  54. Park, J-H., Troxel, A.B., Harvey, R.G. and Penning, T.M. PAH o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines and 8-oxo-dGuo via reactive oxygen species. Chemical Research in Toxicology, 19: 719-28, 2006.
  55. Parzen, M., Lipsitz, S.R., Fitzmaurice, G.M., Ibrahim, J.G. and Troxel, A. Pseudo-likelihood methods for longitudinal binary data with non-ignorable missing responses and covariates. Statistics in Medicine, 25: 2784-96, 2006.
  56. Rebbeck, T.R., Troxel, A.B., Wang, Y., Walker, A.H., Panossian, S, Gallagher, S., Shatalova, E.G., Blanchard, R., Norman, S., Bunin, G., DeMichele, A., Rubin, S.C., Baumgarten, M., Berlin, M., Schinnar, R., Berlin, J.A. and Strom, B.L. Estrogen sulfation genes, hormone replacement therapy, and endometrial cancer risk. Journal of the National Cancer Institute, 98: 1311-20, 2006.
  57. Shen, Y.-M., Troxel, A.B., Vedantam, S., Penning, T.M. and Field, J. Comparison of p53 mutations inducted by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection. Chemical Research in Toxicology, 19: 1441-50, 2006.
  58. Strom, B.L., Schinnar, R., Weber A.L., Bunin, G.R., Berlin, J.A., Baumgarten, M., DeMichele, A.M., Rubin, S.C., Berlin, M., Troxel, A.B. and Rebbeck, T.A. Protective effect of postmenopausal use of combined estrogen plus progestin hormone therapy on endometrial cancer risk. American Journal of Epidemiology, 165: 778-86, 2006.
  59. Brauer, J.A., Shin, D.B., Troxel, A.B., Shapiro, M., Levy, R.M. and Ming, M.E. Characteristics of dermatologists who read dermatopathology slides. Journal of Cutaneous Pathology, 34: 687-92, 2007.
  60. Clark, L.N., Shin, D.B. Troxel, A.B., Khan, S., Sober, A.J. and Ming, M.E. Association between the anatomic distribution of melanoma and sex. Journal of the American Academy of Dermatology, 56: 768-73, 2007.
  61. Gelfand, J.M., Kurd, S.K., Neimann, A.L., Shin, D.B., Margolis, D.J. and Troxel, A.B. Psoriasis and the risk of myocardial infarction – reply. Journal of the American Medical Association, 297: 263-3, 2007.
  62. Gelfand, J.M., Troxel, A.B., Lewis, J.D., Kurd, S.K., Shin, D.B., Wang, X., Margolis, D.J. and Strom, B.L. The risk of mortality in patients with psoriasis: Results from a population-based study. Archives of Dermatology, 143:1493-9, 2007.
  63. Klein, R.Q., Teal, V., Taylor, L., <strong>Troxel A.B</strong>. and Werth, V.P. Number, characteristics, and classification of patients with dermatomyositis seen by dermatology and rheumatology departments at a large tertiary medical center. Journal of the American Academy of Dermatology, 57: 937-43, 2007.
  64. --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
  65. Ochroch, E.A., Troxel, A.B., Frogel, J.K. and Farrar, J.T. The influence of race and socioeconomic factors on patient acceptance of perioperative epidural analgesia. Anesthesia and Analgesia, 105: 1787-92, 2007.
  66. Rebbeck, T.R., Troxel, A.B., Norman, S., Bunin, G.R., DeMichele, A., Baumgarten, M., Berlin, M., Schinnar, R. and Strom, B.L. A retrospective case-control study of the use of hormone-related supplements and association with breast cancer. International Journal of Cancer, 120: 1523-8, 2007.
  67. Rebbeck, T.R., Troxel, A.B., Norman, S., Bunin, G.R., DeMichele, A.,Schinnar, R., Berlin, J. and Strom, B. Pharmacogenetic modulation of combined hormone replacement therapy by progesterone-metabolism genotypes in postmenopausal breast cancer risk. American Journal of Epidemiology, 166: 1392-9, 2007.
  68. Rebbeck, T.R., Troxel, A.B., Shatalova, E.G., Blanchard, R., Norman, S., Bunin, G., DeMichele, A., Baumgarten, M., Berlin, M., Schinnar, R., Berlin, J.A. and Strom, B.L. Lack of effect modification between estrogen metabolism genotypes and combined hormone replacement therapy in post-menopausal breast cancer risk. Cancer Epidemiology, Biomarkers, and Prevention, 16: 1318-20, 2007.
  69. Rebbeck, T.R., Troxel, A.B., Walker, A.H., Panossian, S., Gallagher, S., Shatalova, E.G., Blanchard, R., Norman, S., Bunin, G., DeMichele, A., Baumgarten, M., Berlin, M., Schinnar, R., Berlin, J.A. and Strom, B.L. Pairwise combinations of estrogen metabolism genotypes in post menopausal breast cancer etiology. Cancer Epidemiology, Biomarkers, and Prevention, 16: 444-50, 2007.
  70. Vahdat, L.T., Cohen, D.J., Zipin, D., Lo, K.S., Donovan, D., Savage, D., Tiersten, A., Nichols, G. Troxel, A., Hesdorffer, C.S. Randomized trial of low-dose interleukin-2 vs cyclosporine A and interferon-gamma after high-dose chemotherapy with peripheral blood progenitor support in women with high-risk primary breast cancer. Bone Marrow Transplantation, 40: 267-72, 2007.
  71. Bonilla-Martinez, Z.L., Albrecht, J., Troxel, A.B., Taylor L., Okawa, J., Dulay, S. and Werth, V.P. The cutaneous lupus erythematosus disease area and severity index: a responsive instrument to measure activity and damage in patients with cutaneous lupus erythematosus. Archives of Dermatology 144: 173-80, 2008.
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  73. Mirza, N., Machtay, M., Devine, P.A., Troxel, A., Abboud, S.K. and Doty, R.L. Gustatory impairment in patients undergoing head and neck irradiation. Laryngoscope, 118: 24-31, 2008.
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  75. Yoon, J.S., Newton, S.M., Wysocka, M., Troxel, A.B., Hess, S.D., Richardson, S.K., Lin, J.H., Benoit, B.M., Kasprzycka, M., Wasik, N.A. and Rook, A.H. IL-21 enhances antitumor responses without stimulating proliferation of malignant T cells of patients with Sezary syndrome. Journal of Investigative Dermatology, 128: 473-80, 2008.

Research Publications: peer-reviewed reviews: None

Contributions to peer-reviewed clinical research publications, participation cited but not by authorship: None

Research publications, non peer reviewed:

  1. Troxel, A.B. and Blumenstein, B. Time to event (TTE) methods as a way of analyzing quality of life (QOL) and/or symptom data. American Statistical Association, Proceedings of the Biopharmaceutical Section 73-7, 1997.

Abstracts: (past three years only)

  1. Stettler, N., Stallings, V.A., Troxel, A.B., Zhao, J., Schinnar, R., Nelson S.E., Ziegler, E.E. and Strom, B.L. Rapid infancy weight gain is not associated with adulthood obesity in a cohort of European-Americans. The 3rd Conference of Epidemiological Longitudinal Studies in Europe, 2004.
  2. DeMichele, A., Troxel, A.B., Berlin, J., Weber, A., Bunin, G., Turzo, E., Schinnar, R., Burgh, D., Berlin, M., Grisso, J.A., Rubin, S., Rebbeck, T. and Strom, B.L. Effect of raloxifene on endometrial cancer risk in a population-based case-control study. American Society of Clinical Oncology, 2005.
  3. Troxel, A.B. and Esserman, D.A. Parametric frailty models for quality of life in oncology. Eastern North American Region, International Biometrics Society, 2005.
  4. Esserman, D.A. and Troxel, A.B. Extensions of multivariate survival analysis to include grouped failure time data with application to quality of life. Eastern North American Region, International Biometrics Society, 2005.
  5. Clark, L.N., Shin, D.B., Troxel, A., Khan, S., Sober, A.J. and Ming, M.E. Differences between the sexes in the anatomic distribution of melanoma. Society for Investigative Dermatology, 2005.
  6. Brown, T.T., Troxel, A.B. and Gelfand, J.M. The epidemiology of and risk factors for sunburn in the U.S. population in 2003. Society for Investigative Dermatology, 2005.
  7. Troxel, A.B. Frailty models for quality of life in oncology. Joint Statistical Meetings, American Statistical Association, 2005.
  8. Brauer, J.A., Troxel, A.B, Shin, D.B. and Ming, M.E. Characteristics associated with earlier and later melanoma metastases. Society for Investigative Dermatology, 2006.
  9. Gelfand, J.M., Neimann, A.L., Shin, D.B., Wang, X., Margolis, D.J. and Troxel, A.B. The increased risk of myocardial infarction in patients with psoriasis. J Investigative Dermatol. 2006;126: 47
  10. Ming, M.E., Shin, D.B., Brauer, J.A. and Troxel, A.B. Statins, non-steroidal anti-inflammatory drugs (NSAIDs) and calcium channel blockers are prescribed less frequently for patients who later develop melanoma. Society for Investigative Dermatology, 2006.
  11. Shin, D.B., Brauer, J.A., Khan, S., Troxel, A.B. and Ming, M.E. A prognostic model for development of second primary melanoma. Society for Investigative Dermatology, 2006.
  12. Adamson, P.C., Zhao, H., Sievert, A., Troxel, A.B. and Aplenc, R. A simulation study to define the number of patients necessary to meet primary pharmacokinetic (PK) aims of phase I oncology trials. American Society for Clinical Oncology, 2007.
  13. Amaravadi, R.K., Schuchter, L.M., McDermott, D., Kramer, A., Villaneuva, J., Troxel, A.B., Medina, A., Nathanson, K.L., O’Dwyer, P.J. and Flaherty, K.T. Updated results of a randomized phase II study comparing two schedules of temozolomide in combination with sorafenib in patients with advanced melanoma. American Society for Clinical Oncology, 2007.
  14. Goldfeder, K.L., Troxel, A.B., Rook, A.H. and Kim, E.J. Validity assessment of the CTCL-SI in advanced Mycosis Fungoides/Sezary Syndrome. Society for Investigative Dermatology, 2007.
  15. Kurd, S.K., Lewis, J.L., Troxel, A.B., Margolis, D.J., Strom B.L., Shin, D., Wang, X. and Gelfand, J.M. Patients with severe psoriasis have an increased risk of mortality. Society for Investigative Dermatology, 2007.
  16. Shin, D.B, Brauer, J.A., Wriston, C.C., Troxel, A.B., Ming, M.E. An examination of the relationship between melanoma and other malignancies using the SEER (Surveillance, Epidemiology, and End Results) Registry. Society for Investigative Dermatology, 2007.
  17. Wriston, C.C., Brauer, J.A., Shin, D.B., Schaffer, A., Rubin, A.I., Troxel, A.B., Hudacek, K.D. and Ming, M.E. Solar elastosis is not associated with melanoma metastasis. Society for Investigative Dermatology, 2007.

Editorials, Reviews, Book Chapters, Including Participation in Committee Reports (print or other media:

  1. Troxel, A.B. and Moinpour, C.M. Statistical analysis of quality of life data. In Handbook of Statistics in Clinical Oncology, J. Crowley, ed. New York: Marcel Dekker, Inc., 2001.
  2. Troxel, A.B. and Moinpour, C.M. Design and analysis of quality of life data. In Handbook of Statistics in Clinical Oncology, 2nd ed., J. Crowley, ed. Boca Raton: CRC Press, Inc. 2005.

Books: None

Alternative Media: None

Patents: None

 
Updated: June 5, 2008