CURRICULUM VITAE

Blood Products Advisory Committee


Current Title:

Medical Director, Comprehensive HIV Center
Saint Vincent Catholic Medical Centers, St. Vincent’s Manhattan

Higher Education:

From To Institution & Location
----------------- Cornell University College of Arts and Sciences, AB with honors in chemistry
----------------- Columbia University College of Physicians & Surgeons, MD
1965 1966 Intern in Medicine, Mt. Sinai Hospital, New York, NY
1966 1967 Jr. Asst. Resident in Medicine, Mt. Sinai Hospital, New York, NY
1969 1970 Sr. Asst. Resident in Medicine, Mt. Sinai Hospital, New York, NY
1970 1973 Asst. Resident Physician, Hospital of The Rockefeller University, NYC

Research and Professional Experience:

From To  
1965 1967 and
1969 1970 		PGY 1-3, Internal Medicine, Mt. Sinai Hosp., New York, NY
1967 1969 Asst Preventive Med Officer, Walter Reed Army Medical Ctr., Washington, D.C.
1970 1973 Postdoctoral Research Fellow (H.G. Kunkel), Rockefeller U, NY, NY
1973 1974 Adjunct Asst. Professor, Rockefeller University, New York, NY
1973 1977 Associate, Sloan-Kettering Institute for Cancer Research, NY, NY
1973 1978 Asst. Attending Physician, Clinical Immunology Service, Dept. of Med.
Memorial Hosp. for Cancer & Allied Diseases, NY, NY
1975 1978 Asst. Professor of Medicine, Cornell Univ. Medical College, NY, NY
1975 1978 Head, Laboratory of Human Lymphocyte Differentiation, Sloan -
Kettering Institute for Cancer Research, NY
1976 1978 Head, Lymphocyte Surface Markers Service Laboratory, Sloan-Kettering Institute for Cancer Research, NY, NY
1977 1978 Associate Member, Sloan Kettering Institute for Cancer Research, NY
1978 Consultant, Maternal and Child Health Research Comm., NICHHD.
1978 1982 Associate Scientist, Sloan-Kettering Institute, NY, NY
1978 1984 Associate Professor of Medicine, Mt. Sinai School of Medicine; Head, Div. of Clinical Immunology, Department of Medicine, Mt. Sinai Med. Ctr, New York, NY
1980 Consultant to the Clinical Cancer Program Project Review Comm, NCI
1980 1983 Member, Editorial Board, Journal of Reproductive Immunology
1981 1984 Physician/Consultant in Allergy & Immunology, Veteran's Admin., Bronx, NY
1981 Visiting Professor, Faculty of Med., Univ. of Perugia, Italy
1981 1984 Adjunct Professor, Biology Doctoral Faculty, CUNY
1982 2007 Editorial Advisor, Immunology Abstracts ( Cambridge Scientific)
1983 1986 Member, AIDS Cooperative Group, NCI/NIAID
1983 1999 Member, Scientific Advisory Board, Israel Cancer Research Fund
1983 1995 Member, AIDS Working Group, Div. of Blood Diseases & Resources, NHLBI/NIH
1983 1984 Member, Special Study Section for AIDS, NHLBI/NIH
1984 Special Member, Experimental Immunology Study Section, NIH
1984 Ad Hoc Member, Study Section on AIDS, NIDA
1984 1989 Adjunct Attending Physician, Memorial Sloan-Kettering Cancer Ctr, NYC
1984 ~1987 Member, AIDS Working Group, New York Blood Center, NY
1984 1998 Attending Physician, Long Island Jewish Med. Ctr (LIJMC), New Hyde Park, NY
1984 1998 Section Head, Hematology Research, Div. of Hematology/Oncology, LIJMC, New York
1985 Ad Hoc Member, Immunobiology Study Section, NIH
1986 Ad Hoc Member, NHLBI and Cancer Epidemiology Study Sections, NIH
1986 Consultant, World Health Organization, Safety of Blood and Blood Products
1986 Consultant, Swiss Red Cross AIDS Working Group
1986 1987 Associate Professor of Medicine, CUNY Medical School
1987 1993 and
1997 2000 		Editorial Board, AIDS
1987 1989 Professor of Medicine, Health Sciences Center, SUNY/Stony Brook, NY
1987 1992 Member, Cancer Committee, LIJMC
1987 1998 Member, Infections Committee, LIJMC
1988 present Member, Scientific Advisory Committee, AmFAR
1989 1995 Chairman, Ad Hoc AIDS Working Group, NHLBI/NIH (dissolved 1995)
1989 2000 Professor of Medicine, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY
1989 1995 Member, Technical Advisory Committee, Nassau County Commission on HIV Epidemic
1989 1998 Member, Research Committee, LIJMC
1990 1994 Member, AIDS & Related Research Study Section 1
Division of Research Grants
National Institutes of Health
1992 1994 Member, Bioethics Committee, LIJMC
1994 1996 Chairman, Research Committee, LIJMC (1997, secretary; 1985-98, member)
~1995 1998 Chair, Membership Committee, Clinical Immunology Society
1998 present Medical Director, Comprehensive HIV Center and Section Head, HIV Medicine, Dept of Medicine, Saint Vincents Catholic Medical Center, NY, NY.
1998 present Member, Adjunct Faculty (Laboratory of Ralph Steinman), Rockefeller University, NY, NY
2005 present Member, Ethics Committee, SVCMC, NY, NY
2005 present Member, then Chair (as of 9/06), Blood Products Advisory Committee, CBER, Food and Drug Administration, DHHS, Rockville, MD (full appt as of 2/2006)

Professional Practice & Services:

From To  
1972 1974 Commissioner of Health, Inc. Village of Ocean Beach, NY
1972 1973 Clinical Staff, part time, Phoenix House, NY
1973 1978 Clinical Practice, fulltime staff, Asst. Attending Physician, Memorial Sloan-Kettering Cancer Center, New York
1978 1984 Clinical Practice, fulltime staff, Assoc. Attending Physician, Mt. Sinai Med. Ctr, NY, NY
1984 1998 Clinical Practice, fulltime staff, Attending Physician, Long Island Jewish Med. Ctr, New Hyde Park, NY
1985 1989 Clinical/research practice, adjunct staff, Memorial Sloan-Kettering Cancer Center, New York
1998 present Clinical practice, full time staff, Attending Physician, Saint Vincents Hospital and Medical Center, NY, NY

Certification & Licensure :

1966 New York State Medical Licensure
1972 American Board of Internal Medicine
1979 American Board of Allergy and Immunology, conjoint board ABIM/ABP

Professional & Scientific Societies:

1973 American Federation for Clinical Research
1974 American Assn. for Advancement of Science
1976 American Assn. of Immunologists
1978 American College of Physicians (Fellow)
1978 New York Academy of Sciences
198x (?) Clinical Immunology Society
~1990 Henry Kunkel Society
1991 International AIDS Society

Academic & Professional Honors:

------ Mosby Book Award for Academic excellence ( Columbia)
------ Alpha Omega Alpha
------ The Society of the Sigma Xi
1969 U.S. Army Commendation Medal
1970-73 Helen Hay Whitney Foundation Fellowship (at Rockefeller)
1977 Fellow, American College of Physicians
1979-83 Irma T. Hirschl Charitable Trust Career Scientist Award (at Mt. Sinai Medical Ctr)
Various times Appointed member or chairman of NIH, AmFAR, ICRF, NYBC, CIS, LIJMC advisory boards or committees (v.s.)
1993 Listed among "Best Doctors in New York," New York Magazine
1993 Science Citation Classic (see ref. 40 below)
1995 intermitt Listed in "The Best Doctors in America," Eds. S. Naifeh, G.W. Smith,
Woodward/White Inc, Aiken, SC 1995 (and 2005)
(Town and Country, March 1995)
(American Health, March 1996)
(New York, 1996-2002)
1998 Giraffe Award, Chamber of Commerce, Great Neck, NY
2000 “Hero of Medicine” award, International Assn Physicians for AIDS Care
2005 Listed in "The Best Doctors in America," Aiken, SC 2005

BIBLIOGRAPHY

ORIGINAL ARTICLES:

  1. Rosenkranz HS, Siegal FP. Anomalous sedimentation behavior of dilute protein solutions. Naturwissenschaften. 55:445-6, 1968.
  2. Kunkel HG, Yount WJ, Siegal FP: The varied nature of the immune deficiency states. Trans Amer Clin Climat Assn 83:57-62, 1971.
  3. Siegal FP, Pernis B, Kunkel HG: Lymphocytes in human immunodeficiency states: A study of membrane-associated immunoglobulins. Eur J Immunol 1:482-486, 1971.
  4. Bentwich Z, Douglas SD, Siegal FP, Kunkel HG: Human lymphocyte-sheep erythrocyte rosette formation: Some characteristics of the interaction. Clin Immunol Immunopathol 1:511-522, 1973.
  5. Dickler HB, Siegal FP, Bentwich ZH, Kunkel HG: Lymphocyte binding of aggregated IgG and surface Ig staining in chronic lymphocytic leukemia. Clin Exp Immunol 14:97-106, 1973.
  6. Polliack A, Lampen N, Clarkson BD, DeHarven E, Bentwich Z, Siegal FP, Kunkel HG: Identification of human B and T lymphocytes by scanning electron microscopy. J Exp Med 138:607-624, 1973.
  7. Wernet P, Siegal FP, Dickler H, Fu S, Kunkel HG: Immunoglobulin synthesis in vitro by lymphocytes from patients with immune deficiency: Requirement for a special serum factor. Proc Nat Acad Sci ( USA) 71:531-535, 1974.
  8. Touraine J-L, Incefy GS, Rouraine F, L'Esperance P, Siegal FP, Good RA: T-Lymphocyte differentiation in vitro in primary immunodeficiency diseases. Clin Immunol Immunopathol 3:228-235, 1974.
  9. Incefy GS, Touraine J-L, Touraine F, L'Esperance P, Siegal FP, Good RA: In vitro studies on human T-lymphocyte differentiation in primary immunodeficiency diseases. Trans Assoc Amer Physicians 87:258-262, 1974.
  10. Winchester RJ, Winfield J, Siegal FP, Wernet P, Bentwich Z, Kunkel HG: Analyses of lymphocytes from patients with rheumatoid arthritis and systemic lupus erythematosus. J Clin Invest 54:1082-1092, 1974.
  11. Farnum DG, Mehta G, Moore GGI, Siegal FP. Attempted Reformatskii reaction of benzonitrile,1,4-diketo-3,6-diphenylpyrrolo[3,4-C]pyrrole. A lactam analogue of pentalene. Tetrahedron Lett 29: 2549-2552, 1974.
  12. Grey HM, Kunkel HG, Natvig J, Preud-homme J-L, Rabellino E, Ritts RE, Rowe DS, Seligmann M, Siegal FP, Stjernsward J, Terry WD, Wybran J: Special technical report: Identification, enumeration, and isolation of B and T lymphocytes from human peripheral blood. a. Scand J Immunol, 3:521-532, 1974; b. Clin Immunol Immunopathol 3:584-597, 1974.
  13. Polliack A, Siegal FP, Clarkson BD, Fu SM, Winchester RJ, Lampen N, Siegal M, De Harven R: Surface morphology of leukemic lymphocytes: A scanning electron microscopic and immunological study of 84 cases of lymphocytic leukaemia and related lymphoproliferative disorders. Scan J Haematol 15:359-376, 1975.
  14. Siegal FP, Voss R, Al-Mondhiry H, Polliack A, Hansen JA, Siegal M, Good RA: Association of a chromosomal abnormality with lymphocytes having both T and B markers in a patient with lymphoproliferative disease. Amer J Med 60:157-166, 1976.
  15. Tsakraklides E, Tsakraklides V, Ashikari H, Rosen PP, Siegal FP, Robbins GF, Good Ra: In vitro studies of axillary lymph node cells in patients with breast cancer. J Nat Cancer Inst 54:549, 1975.
  16. Siegal FP, Siegal M, Good RA: Suppression of B-cell differentiation by leukocytes from hypogammaglobulinemic patients. J Clin Invest 58:109-122, 1976.
  17. Gupta S, Pahwa R, O'Reilly R, Good RA, Siegal FP: Ontogeny of lymphocyte subpopulations in human fetal liver. Proc Nat Acad Sci ( USA) 73:919-922, 1976.
  18. Gupta S, Ross G, Good RA, Siegal FP: Surface markers on human eosinophils. Blood 48:755-763, 1976.
  19. Gupta S, Good RA, Siegal FP: Rosette formation with mouse erythrocytes: II. A marker for human B and non-T lymphocytes. Clin Exp Immunol 25:319-327, 1976.
  20. Gupta S, Good RA, Siegal FP: Rosette formation with mouse erythrocytes: III. Studies in patients with primary immunodeficiency and lymphoproliferative disorders. Clin Exp Immunol 26:204-213, 1976.
  21. Siegal FP: IgG on infants' B lymphocytes: Enhanced binding of IgG by IgM-bearing lymphoid cells in early childhood. Scand J Immunol 5:721-729, 1976.
  22. O'Reilly RJ, Everson LK, Emodi G, Hansen J, Smithwock EM, Grimes E, Pahwa S, Pahwa R, Schwartz S, Armstrong D, Siegal FP, Gupta S, Dupont B, Good RA: Effects of exogenous interferon in cytomegalovirus infections complicating bone marrow transplantation. Clin Immunol Immunopathol 6:51-61, 1976.
  23. Jewett MAS, Gupta S, Hansen JA, Cunningham-Rundles S, Siegal FP, Good RA, Dupont B: The use of cryopreserved lymphocytes for longitudinal studies of immune functiuon and enumeration of subpopulations. Clin Exp Immunol 25:449-454, 1976.
  24. Siegal FP, Siegal M: Enhancement by irradiated T cells of human plasma cell production: Dissection of helper and suppressor functions in vitro. J Immunol 118:642-647, 1977.
  25. Gupta S, Pahwa R, Siegal FP, Good RA: Rosette formation with mouse erythrocytes. IV. T, B and third population cells in human tonsils. Clin Exp Immunol 28:347-351, 1977.
  26. Koziner B, McKenzie S, Straus D, Clarkson B, Good RA, Siegal FP: Cell marker analysis in acute moncytic leukemias. Blood 49:895-901, 1977.
  27. Koziner B, Filippa D, Mertelsman R, Gupta S, Clarkson B, Good RA, Siegal FP: Characterization of malignant lymphoma in leukemic phase by multiple differentiation markers of mononuclear cells: Correlation with clinical features and conventional morphology. Amer J Med 63:556-567, 1977.
  28. Filippa DA, Lieberman PH, Erlandson RA, Koziner B, Siegal FP, Turnbull A, Good RA: A study of malignant lymphomas using light and ultramicroscopic, cytochemical and immunological techniques. Correlation with clinical features. Amer J Med 64:259-268, 1978.
  29. Siegal FP, Filippa DA, Koziner B: Surface markers in leukemias and lymphomas. Amer J Path 90:451-459, 1978.
  30. O'Reilly RJ, Dupont B, Pahwa S, Grimes E, Smithwick EM, Pahwa R, Schwartz S, Hansen JA, Siegal FP, Sorell M, Svejgaard A, Jersild C, Thomsen M, Platz R, L'Esperance P, Good RA: Reconstitution in severe combined immunodeficiency by transplantation of marrow from an unrelated donor. New Engl J Med 297:1311-1318, 1977.
  31. Cunningham-Rundles C, Siegal FP, Good RA: Isolation and characterization of a human mononuclear cell Fc receptor. Immunochem 15:365-370, 1978.
  32. Koziner B, Mertelsman R, Siegal FP, Filippa D: Cell marker analysis in hematopoietic neoplasias. Clin Bul ( Memorial Sloan-Kettering Cancer Center) 8:47-53, 1978.
  33. Siegal FP, Siegal M, Good RA: Role of helper, suppressor, and B-cell defects in the pathogenesis of the hypogammaglobulinemias. New Engl J Med 299:172-178, 1978.
  34. DeSousa M, Tan C, Siegal FP, Tan R, Filippa D, Good RA: Immunological parameters in childhood Hodgkin's Disease. II. T and B lymphocytes in the peripheral blood of normal children and in the spleen and peripheral blood of children with Hodgkin's disease. Ped Res 12:143-147, 1978.
  35. Wang AC, Mathur S, Pandey J, Siegal FP, Middaugh CR, Littman GW: Hv(1), a variable-region genetic marker of human immunoglobulin heavy chains. Science 200:327-329, 1978.
  36. Kagan WA, Siegal FP, Gupta S, Goldstein G, Good RA: Early stages of human marrow lymphocyte differentiation: Induction in vitro by thymopoietin and ubiquitin. J. Immunol 122:686-691, 1979.
  37. Evans RL, Wall DW, Platsoukas CD, Siegal FP, Fikrig SM, Testa CM, Good RA: Thymus-dependent membrane antigens in man: Inhibition of cell-mediated lympholysis by monoclonal antibodies to TH-2 antigens. Proc Nat Acad Aci ( USA) 78:544-548, 1981.
  38. Cunningham-Rundles S, Cunningham-Rundles C, Siegal FP, Gupta S, Smithwick FM, Kosloff C, Good RA: Defective cellular immune response in vitro in common variable immunodeficiency. J Clin Immunol 1:65-72, 1981.
  39. Cahill KM, Benach JL, Reich LM, Bilmes E, Zins JS, Siegal FP, Hochweiss S: Red cell exchange: Treatment of babesiosis in a splenectomized patient. Transfusion 2:193-198, 1981.
  40. Cunningham-Rundles S, Cunningham-Rundles C, Ma DI, Siegal FP, Kosloff C, Good RA: Impaired proliferative response to B lymphocyte activators in common variable immunodeficiency. Scand J Immunol 15:279-286, 1982.
  41. Siegal FP, Dikman SH, Arayata RB, Bottone EJ: Fatal disseminated adenovirus 11 pneumonia in an agammaglobulinemic patient. Amer J Med 71:1062-1067, 1981.
  42. Siegal FP, Lopez C, Hammer GS, Brown AE, Kornfeld SJ, Gold J, Hassett J, Hirschman SZ, Cunningham-Rundles C, Adelsberg BR, Parham DJ, Siegal M, Cunningham-Rundles S, Armstrong D: Severe acquired immunodeficiency in male homosexuals manifested by chronic perianal ulcerative herpes simplex lesions. New Engl J Med 305:1439-1444, 1981. (a “Science Citation Classic”)
  43. Borkowsky W, Shenkman L, Suleski P, Sansaricq C, Siegal FP, Hirschhorn R, Smithwick E, Shopsin B and Synderman S: An immunodeficient child with inflammatory bowel disease: involvement of cyclic nucleotides and effects of lithium. Dev Pharm Therap 3:116-128, 1982.
  44. Flamenbaum H, Safai B, Siegal FP, Pahwa S: Lichen planus in two immunodeficient hosts. J Am Acad Derm 5:918-920, 1982.
  45. Siegal FP, Rambotti P, Siegal M, Lopez C, Smith M, Davies TF, Osband M, Estren S: Helper cell function of leukemic Leu-2+, histamine-receptor+, T gamma lymphocytes. J Immunol 129:1775-1781, 1982.
  46. Taff ML, Siegal FP, Geller SA: Outbreak of an acquired immunodeficiency syndrome associated with opportunistic infections and Kaposi's sarcoma in male homosexuals: an epidemic with forensic implications. Amer J Forensic Med & Pathol 3:259-264, 1982.
  47. Masur H, Michelis MA, Wormser G, Lewin S, Gold J, Tapper ML, Giron J, Lerner CW, Armstrong D, Setia U, Sender JA, Siebken RS, Nicholas P, Arlen Z, Maayan S, Ernst JA, Siegal FP, Cunningham-Rundles S: Opportunistic Infection in previously healthy women: Initial manifestations of a community-acquired cellular immunodeficiency. Ann Int Med 97:533-539, 1982.
  48. Oster G, Kilburn KH, Siegal FP: Chemically-induced thymic dysgenesis in the rat: A model of the Digeorge syndrome. Clin Immunol Immunopathol 28:128-134, 1983.
  49. Lopez C, Fitzgerald P, Siegal FP: Severe acquired immunodeficiency syndrome in male homosexuals: Diminished capacity to make interferon-alpha in vitro is associated with susceptibility to opportunistic infections. J Inf Dis 148:962-966, 1983.
  50. Cunningham-Rundles C, Siegal FP, Smithwick EM, Lion A, Cunningham-Rundles S, O'Malley J, Barandun S and Good RA: Efficacy of intravenous immune globulin in primary humoral immunodeficiency disease. Ann Int Med 101:435-439, 1984.
  51. Leiderman IZ, Greenberg ML, Adelsberg BR, Siegal FP: Myelopoiesis in AIDS. In: Gottlieb MS, Groopman JE, eds., Acquired Immune Deficiency Syndrome: UCLA Symposium on Molecular and Cellular Biology, New Series, A.R. Liss, New York, NY, 16:281-289, 1984.
  52. Geller SA, Muller R, Greenberg ML, Siegal FP: Acquired immunodeficiency syndrome: Distinctive features of bone marrow biopsies. Arch Pathol Lab Med 109:138-141, 1985.
  53. Desai A, Taff ML, Kamino H, Siegal FP: The acquired immunodeficiency syndrome. Med Grand Rnds 3:196-205, 1985.
  54. Greenberg ML, Siegal FP: Cell replication in an immunologically stimulated (?) cell population in human bone marrow, in Bone, VT, ed., Hematopoietic Cellular Proliferation, Ann NY Acad Sci 459:67-72, 1985.
  55. Bast RC, Siegal FP, Runowiscz C, Schonholz D, Klug T, Surawski V, Cohen CJ, Knapp RC: Elevation of serum CA 125 prior to diagnosis of an epithelial ovarian carcinoma. Gynec Oncol 22:115-120, 1985.
  56. Glaser JB, Morton-Kute L, Berger SR, Weber J, Siegal FP, Lopez C, Robbins W, Landesman SH: Recurrent Salmonella typhimurium bacteremia associated with the acquired immunodeficiency syndrome. Ann Int Med 102:189-193, 1985.
  57. Benkov KJ, Stawski C, Sirlin SM, Klapholz MB, Siegal FP, LeLeiko NS. Atypical presentation of childhood acquired immune deficiency syndrome mimicking Crohn's disease: nutritional considerations and management. Am J Gastroenterol 80:260-5, 1985.
  58. Siegal FP, Lopez C, Fitzgerald PA, Shah K, Baron P, Leiderman IZ, Imperato D, Landesman SH: Opportunistic infections in acquired immune deficiency syndrome result from synergistic defects of both the natural and adaptive components of cellular immunity. J Clin Invest 78:115-123, 1986.
  59. Messina C, Kirkpatrick D, Fitzgerald PA, O'Reilly RJ, Siegal FP, Cunningham-Rundles C, Blaese M, Oleske J, Pahwa S, Lopez C: Natural Killer cell function and interferon generation in patients with primary immunodeficiencies. Clin Immunol Immunopathol 39:394-404, 1986.
  60. Anand R, Siegal FP, Reed C, Cheung T, Forlenza S, Moore J: Noncytocidal natural variants of human immunodeficiency virus (HIV): Isolation from AIDS patients with neurological disorders. Lancet 2:234-238, 1987.
  61. Cunningham-Rundles C, Siegal FP, Cunningham-Rundles S, Lieberman P: Incidence of cancer in 98 patients with common varied immunodeficiency. J Clin Immunol 7:294-299, 1987.
  62. Leiderman IZ, Greenberg ML, Adelsberg BR, Siegal FP: A glycoprotein inhibitor of in vitro granulopoiesis associated with the acquired immune deficiency syndrome (AIDS). Blood 70:1267-1272, 1987.
  63. Burger H, Paul D, Siegal FP, Wendel I, Neff S, Eilbott D, Gehan K, Grimson R, Weiser B: Comparison of antigen immunoassay and reverse transcriptase assay for monitoring human immunodeficiency virus infection in an antiviral trial. J Clin Micro 26:1890-1892, 1988.
  64. Green J, Katz S, Phillips G, Bank S, Ilardi C, Hadju E, Siegal, FP: Percutaneous sonographic needle aspiration biopsy of endoscopically negative gastric carcinoma. Am J Gastro 83:1150-1153, 1988.
  65. Smith MA, Hirschfield LS, Zahtz G, Siegal FP: Pneumocystis carinii otitis media. Am J Med 85:745-746, 1988.
  66. Moroz C, Misrock SL, Siegal FP: Isoferritins in HIV infections: Relation to clinical stage, CD8 lymphocyte binding and the pathogenesis of AIDS. AIDS 3:11-16, 1989.
  67. Burger H, Paul D, Siegal FP, Wendel I, Neff S, Eilbott D, Gehan K, Grimson R, Weiser B. Comparison of antigen iImmunoassay and reverse transcriptase assay for monitoring human immunodeficiency virus infection in an antiviral trial. J Clin Micro 26:1890-1892, 1988.
  68. Buzy JM, Brenneman DE, Siegal, FP, Ruff, MR, Pert, CB. GP120-like neuronal killing in vitro by the cerebrospinal fluid from a cognitively impaired AIDS patient. Amer J Med 87:361-362, 1989.
  69. Burger H, Weiser B, Eilbott DJ, Gehan K, Flaherty K, Gulla J, Neff S, Davidson B, Anand R, Siegal FP: Efficacy of rifabutin in the treatment of AIDS-Related Complex. AIDS 3:823-827, 1989.
  70. Levine B, Leiderman IZ, Siegal FP, Mayer LF, Cunningham-Rundles C: Genotypes of the group-specific component protein in Black intravenous drug abusers. J Inf Dis 159:147-148, 1989.
  71. Greenberg RE, Mir R, Bank S, Siegal FP: Resolution of intestinal cryptosporidiosis after treatment of AIDS with AZT. Gastroenterology 97:1327-1330, 1989.
  72. Siegal FP, Eilbott D, Burger H, Gehan K, Davidson B, Kaell AT, Weiser B: Dose-limiting toxicity of rifabutin in AIDS-related complex: Syndrome of arthralgia/arthritis. AIDS 4:433-441, 1990.
  73. Maesaka JK, Cusano AJ, Thies HL, Siegal FP, Dreisbach AW: Hypouricemia in acquired immunodeficiency syndrome. Amer J Kidney Dis 15:252-257, 1990.
  74. Cusano AJ, Thies HL, Siegal FP, Dreisbach AW, Maesaka JK: Hyponatremia in patients with acquired immune deficiency syndrome. J AIDS 3:949-953, 1990.
  75. Santiago-Schwarz F, Panagiotopoulos C, Siegal FP, Sawitsky A, Rai KR: Interleukin 4, but not tumor necrosis factor or phorbol myristate acetate, augments the sensitivity of B-CLL cells to lysis by LAK cells. Blood 76:1355-1360, 1990.
  76. Laurence J, Siegal FP, Schattner E, Gelman IH, Morse S: Acquired immunodeficiency without evidence of infection with human immunodeficiency virus types 1 and 2. Lancet 340:273-74, 1992
  77. Blumstein M, Bank S, Greenberg RE, Abrol RP, Kahn L, Siegal F: Immunoproliferative small intestinal disease in an American patient with lymphoma and macroamylasemia. Gastroenterology 103: 1071-4, 1992.
  78. Howell DM, Feldman M, Siegal FP, Pettera L, Fitzgerald-Bocarsly P: Peripheral blood of AIDS patients contains cells capable of providing accessory function for the natural killer cell mediated lysis of Herpes simplex virus infected targets despite low interferon- α production. J AIDS 6:15-23, 1992.
  79. Maytal J, Horowitz S, Lipper S, Poiesz B, Chang YW, Siegal FP: Progressive nemaline rod myopathy in a woman co-infected with HIV-1 and HTLV-2. Mt Sinai J Med 60:242-246, 1993.
  80. Nightingale SD, Cameron WD, Gordin FM, Sullam PM, Cohn DL, Chaisson ER, Eron LJ, Sparti PD, Bihari B, Kaufman DL, Stern JJ, Pearce DD, Weinberg WG, LaMarca A, Siegal FP: Two controlled trials of rifabutin prophylaxis against Mycobacterium avium complex infection in AIDS. N Engl J Med 329:828-833, 1993.
  81. Bonagura VR, Siegal FP, Abramson AL, Santiago-Schwarz F, O'Reilly ME, Shah K, Drake D, Steinberg BM: Enriched HLA-DQw3 phenotype and decreased class I major histocompatibility complex antigen expression in recurrent respiratory papillomatosis. Clin Diagn Lab Immunol, 357-360, 1994.
  82. Bhuiya TA, Shodell M, Fitzgerald-Bocarsly PA, Murasko D, Shah K, Drake D, Siegal FP: Interferon-alpha (IFN- α ) generation in mice responding to challenge with uv-inactivated herpes simplex virus. J Interferon Res 14:17-24, 1994.
  83. Siegal FP, Shodell M, Shah K, Drake D, Hoffman M, Sawitsky A, Janson D, Fitzgerald-Bocarsly P, Rai KR: Impaired interferon alpha response in hairy cell leukemia is corrected by therapy with 2-chloro-2'-deoxyadenosine: Implications for susceptibility to opportunistic infections. Leukemia 9:1474-1479, 1994.
  84. Dube S, Spicer T, Bryz-Gornia V, Jones B, Dean T, Love J, Ferrer F, Esteban N, Harrington W Jr., Glaser J, Dube DK, Williams A, Dosik H, Siegal F, Poiesz BJ: A rapid and sensitive method of identification of HTLV-II subtypes. J Med Virol 45:1-9, 1995.
  85. Laurence J, Mitra D, Steiner M, Lynch DH, Siegal FP, Staino-Coico L: Apoptotic depletion of CD4+ T cells in idiopathic CD4+ lymphocytopenia. J Clin Invest 97:672-80, 1996.
  86. Wallace MR, Moss RB, Beecham HJ, Grace CJ, Hersh EM, Peterson E, Murphy R, Shepp DH, Siegal FP, Turner JL, Safrin S, Carlo DJ, Levine AM. Early clinical markers and CD4 percentage in subjects with human immunodeficiency virus infection. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Aug 1;12(4):358-62 (1996)
  87. Mattana J, Siegal FP, Schwarzwald E, Molho L, Sankaran R, Gooneratne R, Ahuja T, Singhal P: AIDS-associated membranous nephropathy with advanced renal failure: Response to prednisone. Amer J Kidney Dis, 30:116-119, 1997
  88. Fang G, Siegal FP, Weiser B, Grimson R, Anastos K, Back S, Burger H: Measurement of serum HIV-1 RNA load distinguishes progressive from non-progressive HIV-1 infection in men and women. Clin Inf Dis, 25:332-333, 1997
  89. Siegal FP, Kadowaki N, Shodell M, Fitzgerald-Bocarsly, PA, Shah, K, Ho, S, Antonenko S, Liu, Y-J: The nature of the principal type 1 interferon producing cells in human blood. Science 284:1835-37,1999.
  90. Mattana J. Siegal FP, Sankaran R, Singhal P: Absence of AIDS-related increase in systolic blood pressure in ambulatory patients with HIV infection. Amer J Med Sci 317:232-7, 1999
  91. Poiesz BJ, Papsidero LD, Ehrlich G, Sherman M, Dube S, Poiesz M, Dillon K, Ruscetti F, Slamon D, Fang C, Williams A, Duggan S, Glaser J, Gottlieb A, Goldberg J, Ratner L, Phillips P, Han T, Friedman-Kien A, Siegal F, Rai K, Sawitsky A, Sheremata LWA, Dosik H, Cunningham C, Montagna R. Prevalence of HTLV-I-associated T cell lymphoma. Amer J Hematol 66:32-38, 2001
  92. Shodell M, Siegal FP. Corticosteroids depress interferon-alpha producing plasmacytoid dendritic cells in human blood. J All Clin Immunol 108:446-448, 2001
  93. Siegal FP, Fitzgerald-Bocarsly P, Holland BK, Shodell, M: Interferon-α a generation and immune reconstitution during antiretroviral therapy for human immunodeficiency virus infection. AIDS 15:1603-1612, 2001.
  94. Yang, OO, Hauser MA, Ferbas J, Shih R, Hultin LE, Boscardin WJ, Siegal FP, Shodell M, Shearer G, Greni E, Carrington M, O’Brien S, Price CB, Matud J, Detels R, Jamieson B, Giorgi JV. Immunologic profile of highly-exposed yet HIV-1-seronegative men. AIDS Hum Retroviruses 18(14):1051-65, 2002
  95. Shodell M, Siegal FP. Circulating, interferon-producing plasmacytoid dendritic cells decline during human ageing. Scand J Immunol 56:518-521, 2002.
  96. Shodell M, Shah K, Siegal FP. Circulating human plasmacytoid dendritic cells are highly sensitive to corticosteroid administration. Lupus. 12:222-30 (2003)
  97. Ambrose JA, Gould RB, Kurian DC, DeVoe MC, Pearlstein NB, Coppola JT, Siegal FP. Frequency of and outcome of acute coronary syndromes in patients with human immunodeficiency virus infection. Am J Cardiol 92: 301-3 (2003)
  98. Granelli-Piperno A, Golebiowska A, Trumpfheller C, Siegal FP, Steinman RM. HIV-1 infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation. Proc Natl Acad Sci U S A 101:7669-74 (2004). (Epub 2004 May 05).
  99. Finke JS, Shodell M, Shah K, Siegal FP, Steinman RM. D endritic cell numbers in the blood of HIV-1 infected patients before and after changes in antiretroviral therapy. J Clin Immunol 24:647-52 (2004).   100. Arrode G, Finke JS, Zebroski H, Siegal FP, Steinman RM. CD8(+) T cells from most HIV-1-infected patients, even when challenged with mature dendritic cells, lack functional recall memory to HIV gag but not other viruses. Eur J Immunol. 35:159-70 (2005).
  100. Bozzacco L, Trumpfheller C, Siegal FP, Mehandru S, Markowitz M, Carrington
    M, Nussenzweig MC, Piperno AG, Steinman RM.  DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes.  Proc Natl Acad Sci U S A. 104:1289-94 (2007. (Epub 2007 Jan 17).

EDITORIALS:

Siegal FP. Inhibition of T-rosette formation by Hodgkin-disease serum. N Engl J Med 1976; 295:1314-1315

Siegal FP. Suppressors in the network of immunity. N Engl J Med 1978; 298:102-103

LETTERS: 

  1. Siegal FP, Ouellette JJ. Protecting pigeon-handlers. Lancet. 1969;1(7597):733-4.
  2. Gupta S, Siegal FP. In vitro inhibition of E rosettes by human amniotic fluid. N Engl J Med 1975; 293:302-303
  3. Siegal FP. Lithium for steroid-induced psychosis. N Engl J Med. 1978; 299:155-6.
  4. Siegal FP. Normal delayed-type skin reactions in early stages of acquired cellular immunodeficiency.
    N Engl J Med. 1982;307:184
  5. Hassett JM, Zaroulis CG, Greenberg ML, Siegal FP. Bone marrow transplantation in AIDS. N Engl J Med. 1983;309:665
  6. Lopez C, Fitzgerald PA, Siegal FP. The generation of interferon-alpha by mononuclear cells from patients with AIDS and the role of serum interferon. J Inf Dis 1984;150: 158-9
    7.  

BOOKS, CHAPTERS IN BOOKS, AND REVIEW ARTICLES:

  1. Wernet P, Siegal FP, Dickler H, Bentwich Z, Fu S, Kunkel HG: B and T cells in various disease states: Immature B cells in the blood of certain patients with immune deficiency. 7th International Symposium on Immunopathology, Pergamon Press, 169-184, 1973.
  2. Siegal FP, Wernet P, Fu SM, Kunkel HG: B lymphocytes lacking surface Ig in patients with immune deficiency: Initiation of Ig synthesis in culture in cells of a patient with thymoma. In: Immunodeficiency in Man and Animals, Birth Defects, Original Article Series, Vol XI, No 1, pp 40-41, 1975.
  3. Kagan WA, Incefy GS, Gupta S, Siegal FP, Goldstein G, Good RA: Induction of surface receptors on granulocyte, T and B cell precursors in human bone marrow by thymic and non-thymic agents. Proc Tenth Leukocyte Cult Conf, Academic Press, 719-725, 1976.
  4. Cunningham-Rundles C, Siegal FP, Good RA: Isolation of the active site of a mononuclear cell Fc receptor. In: Cell Biology and Immunology of Leukocyte Function, Quastel M Ed, Academic Press (NY), pp 253-257, 1979.
  5. Siegal FP, Siegal M: Suppressor cell populations in normal and immunodeficiency humans. In: Regulatory T Lymphocytes, Proc. Third P & S Biomedical Sciences Symposium, Pernis B, and Vogel HG, eds, Academic Press, pp 363-379, 1980.
  6. Cunningham-Rundles S, Cunningham-Rundles C, Ma DI, Siegal FP, Gupta S, Smithwick EM, Kosloff C, Good RA: Use of microbial B lymphocyte activators in primary immunodeficiency. Proc 14th Leukocyte Culture Conf 653-656, 1981.
  7. Cunningham-Rundles C, Smithwick EM, Siegal FP, Day NK, Cunningham-Rundles S, Koziner B, Lion A, Barandun S. O'Malley J, Good RA: Treatment of primary humoral immunodeficiency disease with intravenous (pH 4.0-treated) gammaglobulin. In: Immunohemotherapy, Ed. Nydegger, UE, Acad Press, New York, 1981, pp. 283-290.
  8. Cunningham-Rundles C, Day NK, Wahn V, Smithwick EM, Siegal FP, Gupta S, Good RA: Reactions to intravenous gammaglobulin infusions and immune complex formation. In: Immunohemotherapy, Ed. Nydegger, UE, Academic Press, New York, 1981, pp. 447-449.
  9. Fitzgerald PA, Siegal FP, Lopez C: Role of interferon in natural kill of herpesvirus infected fibroblasts. In: NK Cells and Other Natural Effector Cells, Ed. RB Herberman, Academic Press, NY, 1982, pp 1445-1450.
  10. Siegal FP: Herpes simplex infections in homosexual men, In: Ma P, Armstrong D, eds., The acquired immune deficiency syndrome and infections of homosexual men. Yorke Medical, New York 1983, 107-116.
  11. Siegal FP: Perspective on therapy for acquired immune deficiency syndrome (AIDS), ibid, 397-406.
  12. Lopez C, Fitzgerald P, Siegal FP: Immunologic alterations in acquired immune deficiency syndrome (AIDS), Ibid, 342-349.
  13. Siegal FP, Siegal M: AIDS: The Medical Mystery, Grove Press, NY 1983.
  14. Lopez C, Fitzgerald PA, Siegal FP, Landesman S, Gold J, Krown SE. Deficiency of interferon-alpha generating capacity is associated with susceptibility to opportunistic infections in patients with AIDS. Ann N Y Acad Sci. 1984;437:39-48.
  15. Siegal FP: Immune function and dysfunction in AIDS. Semin Oncol 11:29-39, 1984.
  16. Siegal FP, Oleske JM: Management of the acquired immune deficiency syndrome: Is there a role for immune globulins? In: Clinical Use of Intravenous Immunoglobulins, Morell A, Nydegger UE, eds, Academic Press, London, 1986, pp 373-384.
  17. Siegal FP: Clinical expression of LAV/HTLV-III infections in the USA, Western Europe and Australia, In: AIDS: The Safety of Blood and Blood Products, Petricciani JC, Gust ID, Hoppe PA, Krijnen HW eds, John Wiley & Sons Ltd, 1987 (for the World Health Organization, Geneva), pp 11-28.
  18. Siegal FP: The Immune Deficiency of AIDS. In: AIDS and other Manifestations of Human Immunodeficiency Virus Infection. Wormser GP, Stahl R and Bottone BJ eds., Noyes Publications, pp 304-330, 1987.
  19. Siegal FP, Shah K, Imperato D, Walczak M, Gehan K: Negative immunologic surveillance for HIV transmission by intravenous immune globulins (IG). In: Clinical Immunology. Pruzanski W, Seligmann M, eds., Elsevier Science Publishers, 1987, pp 221-224.
  20. Siegal FP: Similarities between chronic lymphocytic leukemia and immunodeficiency disorders. In: CLL: Recent Progress and Future Directions (UCLA Symposia, New Series, Vol 59). Gale RP, Rai KR, eds. AR Liss, Inc, New York, 1987, pp 39-53.
  21. Fitzgerald-Bocarsly P, Lopez C, Siegal FP: Immunologic responses in AIDS. In: AIDS and Infections of Homosexual Men; Second edition, Ma P & Armstrong D, eds., 1989, pp 383-390.
  22. Siegal FP: Immunodeficiency diseases and thymoma. In: Surgery of the Thymus; J-C Givel, ed; Chapter 14, pp 189-198, 1989.
  23. Siegal FP and Cheung T: Neoplastic diseases related to human immunodeficiency virus (HIV). In: Textbook of Clinical Oncology, New Edition; Arthur I. Holleb, Diane Fink, eds. for American Cancer Society, 1990, Chapter 36, Textbook of Oncology.
  24. Siegal FP: Management of HIV infections: Method of Frederick P. Siegal, M.D., FACP. In: Conn's Current Therapy, 1990 Edition; Robert E. Rakel, ed., 1990.
  25. Siegal, FP: Antiretroviral therapy in HIV infection. Lesson 16. In: Pulm Crit Care Update, 1993 8:2-7.
  26. Siegal FP: Conference Notes: Rapporteur Session, Mycobacterium avium complex, Eighth International Conference on AIDS, Amsterdam, The Netherlands, 1992. PAACnotes 4: 242-243, 1993.
  27. Siegal FP. The recognition of AIDS (This Week's Citation Classic), Curr Contents Clin Med 21: (50) 9, 1993
  28. Siegal FP, Weiser B, Burger H, Gehan K, Gold JWM, Wynne BA, Nightingale SD. The development of rifabutin for prophylaxis against Mycobacterium avium complex infection. Eur Respir Rev, 5, 1994.
  29. Siegal, FP. Rifabutin for prophylaxis of Mycobacterium avium complex (MAC) infection in AIDS. Clin Inf Dis 22 (Suppl 1):S23-31 (1996)
  30. Siegal, FP, AIDS mimics: more than congenital disorders, (editorial), Infections in Medicine 14:870-871 (1997)
  31. Spear G, Siegal FP. Innate immunity and HIV. (Review article). AIDS 15 (suppl 5): S127-S137 (2001)
  32. Siegal FP, Shodell M. Clinical studies of AIDS and the recognition of plasmacytoid dendritic cells (pDC). Clin Appl Immunol Rev 3:213-221 (2003)
  33. Siegal F. Interferon-producing plasmacytoid dendritic cells and the pathogenesis of AIDS. Res Initiat Treat Action. 8:10-13 (2003)
 
Updated: June 5, 2008