Curriculum Vitae

Blood Products Advisory Committee

Simone A. Glynn, M.D., M.P.H.

Education

M.P.H., Epidemiology-Biostatistics, George Washington University, Washington DC, ----
[MPH Thesis: Evaluation of the relationship between spontaneous adverse drug reaction reports and time postmarketing. Food and Drug Administration, Washington, DC]

M.D.C.M, McGill University, Canada, ----
M.Sc., Physiology (Hematology), McGill University, Canada, ----
B.A., Biology, Barnard College, New York, ----

Cancer Prevention Fellowship, National Cancer Institute, Maryland, ----
Family Practice Residency, Fairfax Family Practice Center, Virginia, ----
Internship, Fairfax Hospital, Virginia, ----

Professional experience

September 2006 to present, National Heart, Lung, and Blood Institute (Bethesda, MD):

Branch Chief, Transfusion Medicine and Cellular Therapeutics Branch (TMCTB), Division of Blood Diseases and Resources (DBDR), National Heart, Lung, and Blood Institute (NHLBI), NIH. The TMCTB supports and directs a program of basic, applied, and clinical research in the areas of transfusion medicine, hematopoietic stem cell transplantation, stem cell biology and cellular therapies.

August 1995 to September 2006, Westat (Rockville, MD):

Co-principal investigator of the coordinating center for the Retrovirus Epidemiology Donor Studies I and II (REDS-I and -II), a large NHLBI multicenter program whose primary mission is to initiate and facilitate epidemiologic and laboratory investigations of HIV and other transfusion-transmissible agents in blood donors and to study any major issue pertaining to blood products’ safety and availability.

Co-principal investigator of the coordinating center for the REDS-II International program, whose ob jectives are to conduct epidemiologic, laboratory, and survey research on blood donors in selected resource-limited countries (China and Brazil) seriously impacted by the AIDS epidemic to help increase blood supply safety and availability.

Director of the Analysis Unit for the Retrovirus Epidemiology Donor Studies I and II (REDS-I and -II) and REDS-II International

Senior Medical Epidemiologist (1999-2006) for the Plasma Protein Therapeutics Association (PPTA) TTVI-risk assessment project

Co-principal investigator for an R01 grant received to design and conduct a large telephone population survey aimed at evaluating motivations and deterrents to blood donation behavior (2003-present).

Institutional Review Board (IRB) member (1998-2006):

Medical reviewer (1995-1999):

Served on a medical diagnosis review panel for a large cohort study of HTLV infected and HTLV non-infected participants.

Scientific Reviewer:

Grants (NIH)

American Association of Blood Banks Annual Conference Abstracts Review

Manuscripts submitted to scientific journals (JAMA, Transfusion, Vox Sanguinis)

1992 to 1995, Cancer Prevention Studies Branch, National Cancer Institute, Bethesda, MD

Cancer Prevention fellow:

Training in public health prevention programs.

Worked with data from the alpha-tocopherol, beta-carotene randomized clinical trial conducted in Finland (development of lung cancer was the primary endpoint)

Conducted a cohort study to evaluate the relationship between alcohol intake and colorectal cancer.

Conducted a case-control study to evaluate the association between folic acid intake and colorectal cancer.

1989 to 1992, Family Practice - Burke Family Practice, Burke, VA

Family physician in a clinical practice (pediatric and adult) with in-hospital coverage.

------------, Family Practice - Fairfax Family Practice, Fairfax, VA

Internship ( Fairfax Hospital, VA) and fellowship in Family Practice- In and out patient coverage.

------------, McGill Cancer Center, McGill University, Canada

Laboratory Scientist (hematology):
Derivation of an in vitro line of myeloblastic cells from an in vivo Brown Norway rat promyelocytic leukemic cell model and development of monoclonal antibodies against this new cell line to identify tumor-specific antigens.

Teaching Experience

1995 to 2006 , Westat ( Rockville, MD):
Preceptor for graduate students.

------------, McGill University, Canada:
Teacher assistant in physiology

Awards received

Delta Omega, ----
Hewlett Packard Prize for Academic Excellence, McGill University, ----
Prix d’Excellence, L’Association des Medecins Award, McGill University, ----
University Scholar, McGill University, ----
McConnel Award, McGill University, -------
Phi Beta Kappa, Delta of New York, ----

Professional Societies

American Association of Blood Banks (AABB)

American Association of Family Practice (AAFP)

Publications:

Germain M, Glynn SA, Schreiber GB, Gelinas S, King M, Jones M, Bethel J, Tu Y. Determinants of return behavior: A comparison of current and lapsed donors. Transfusion. In press.

Kleinman SH, Glynn SA, Lee TH, Tobler L, Montalvo L, Todd D, Kiss JE, Shyamala S, Busch MP for the National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor. Study (REDS-II). Prevalence and quantitation of parvovirus B19 DNA levels in blood donors using a sensitive PCR screening assay. Transfusion. In press.

Mathew SM, King MR, Glynn SA, Dietz SK, Caswell SL, Schreiber GB. (in press). Opinions about donating blood among those who never gave and those who stopped: A focus group assessment. Transfusion.2007: 47:729-735

Glynn SA, Schreiber GB, Murphy EL, Kessler D, Campbell JG, Smith JW, King M, Mathew S, Wright D. Factors Influencing the Decision to Donate: A Racial/Ethnic Comparison. Transfusion. 2006; 46:980-990.

Busch MP, Glynn SA, Stramer SL, Orland J, Murphy E, Wright DJ, Kleinman S. (in press) Correlates of Hepatitis C Virus (HCV) RNA Negativity among HCV Seropositive Blood Donors. Transfusion 2006; 46:469-475.

Busch MP, Wright DJ, Tobler LH, Stramer SL, Custer B, Kleinman SH, Prince HE, Bianco C, Foster G, Petersen LR, Nemo G, Glynn SA. West Nile Virus infections projected from blood Donor Screening Data, United States, 2003. Emerging Infectious Disease;, 2006: www.cdc.gov/eid, Vol 12 (3)

Schreiber GB, Schlumpf KS, Glynn SA, Wright DJ, Tu Y, King MR, Higgins MJ, Kessler D, Gilcher R, Guiltinan AM. (in press) Convenience: the Bane of our Existence and Other Barriers to Donating. Transfusion.

Busch MP, Glynn SA, Wright DJ, Hirschkorn D, Laycock ME, McAuley J, Tu Y, Giachetti C, Gallarda J, Heitman J, Kleinman SH. (2005) Relative sensitivities of licensed nucleic acid amplification tests for detection of viremia in early human immunodeficiency virus and hepatitis C virus infection. Transfusion; 45: 1853-1863.

Kleinman SH, Glynn SA, Higgins M, Triulzi D, Smith J, Nass CC, Garratty G, Murphy EL, LeParc GF, Schreiber G, King M, Chamberland M, Nemo G. (2005). The RADAR Repository: A Resource for Studies of Infectious Agents and their Transmissibility by Transfusion. Transfusion; 45:1073-1083

Glynn SA, Wright DJ, Kleinman SH, Hirschkorn D, Tu Y, Heldebrant C, Smith R, Giachetti C, Gallarda J, Busch MP. (2005). D ynamics of Viremia in Early Hepatitis C Virus Infection. Transfusion; 45:994-1002.

Busch MP, Glynn SA, Stramer SL, Strong DM, Caglioti S, Wright DJ, Pappalardo B, Kleinman SH. (2005). A new strategy for estimating risk of transfusion-transmitted viral infections based on rates of detection of recently infected donors. Transfusion; 45:254-264.

Kleinman S, Glynn SA, Busch M, Todd D, Powell L, Pietrelli L, Nemo G, Schreiber G, Bianco C, Katz L. (2005). The 2003 West Nile Virus US Epidemic: The America’s Blood Centers Experience. Transfusion; 45: 469-479.

Sanchez AM, Schreiber GB, Nass CC, Glynn S, Kessler D, Hirschler N, Fridey J, Bethel J, Murphy E, Busch MP. (2005). The Impact of Male-to-Male Sexual Experience on Risk Profiles of Blood Donors. Transfusion; 45:1-10.

Schreiber GB, Sharma UK, Wright DJ, Glynn S, Ownby HE, Tu Youngling, Garratty G, Piliavin J, Zuck T, Gilcher R. (2005). First year donation patterns predict long term commitment for first-time donors. Vox Sanguinis; 88: 114-121.

Tobler LH, Bianco C, Glynn SA, Schreiber GB, Dille BJ, Prince HE, Lanciotti RS, Linnen JM, Gallarda J, Shyamala V, Smith D, Kleinman SH, Busch MP. (2005). Detection of West Nile virus RNA and antibody in frozen plasma components from a voluntary market withdrawal during the 2002 peak epidemic. Transfusion ; 45:480-486.

Wang B, Schreiber GB, Glynn SA, Kleinman S, Wright DJ, Busch MP. (2005). Does prevalence of transfusion-transmissible viral infections reflect corresponding incidence in the United States blood donors? Transfusion; 45:1089-1096.

Stramer SL, Glynn SA, Kleinman SH, Strong DM, Caglioti S, Wright DJ, Dodd RY, Busch MP. (2004). Detection of HIV-1 and HCV Infections among Antibody-Negative Blood Donors by Nucleic Acid-Amplification Testing. The New England Journal of Medicine; 351:760-8

Satten, G.A., Kong, F., Wright, D.J., Glynn, S., and Schreiber, G. (2004). How special is a “special” interval: Modeling departure from length-based sampling in renewal processes. Biostatistics, 5, 145-151.

Kuhns MC, Kleinman SH, NcNamara AL, Rawal B, Glynn S, Busch MP. (2004). Lack of correlation between HBsAg and HBV DNA levels in blood donors who test positive for HBsAg and Anti-HBc: implications for future HBV screening policy. Transfusion ; 44:1332-1339.

Kleinman, S., Wang, B., Wu, Y., Glynn, S.A., Williams, A., Nass, C., Ownby, H., and Busch, M.P. (2004). The donor notification process from the donor’s perspective. Transfusion, 44, 658-666.

Garratty, G., Glynn, S.A., and McEntire, R. (2004). ABO and Rh(D) phenotype frequencies of different racial/ethnic groups in the United States. Transfusion, 44, 703-706.

Wang, B., Higgins, M.J., Kleinman, S., Schreiber, G.B., Murphy, E.L., Glynn, S.A., Wright, D.J., Nass, C.C., Chang, D., and Busch, M.P. (2004). Comparison of demographic and donation profiles and transfusion-transmissible disease markers and risk rates for previously transfused and non-transfused blood donors. Transfusion, 44, 1243-1251.

Damesyn, M.A., Glynn, S.A., Schreiber, G.B., Ownby, H.E., Bethel, J., Fridey, J., McMullen, Q., Garratty, G., and Busch, M.P., for the NHLBI Retrovirus Epidemiology Donor Study. (2003). Behavioral and infectious disease risks in young blood donors: Implications for recruitment. Transfusion, 43, 1596-1603.

Pellett, P.E., Wright, D.J., Engels, E.A., Ablashi, D.V., Dollard, S.C., Forghani, B., Glynn, S.A., Goedert, J.J., Jenkins, F.J., Lee, T.H., Neipel, F., Todd, D., Whitby, D., Nemo, G., and Busch, M.P. (2003). Multicenter comparison of serologic assays and estimation of human herpesvirus 8 seroprevalence in U.S. blood donors. Transfusion, 43, 1260-1268.

Rugege Hakiza, S., Glynn, S.A., Hutching, S., Bethel, J., Nass, C.C., McEntire, R.L., Hirschler, N., Campbell, J., Ladavac, A., and Schreiber, G.B. (2003). Do blood donors read and understand prescreening educational materials? Transfusion, 43, 1075-1083.

Glynn, S.A., Busch, M.P., Schreiber, G.B., Murphy, E.L., Wright, D.J., Tu, Y., and Kleinman, S.H. (2003). The effect of a national disaster on blood supply and safety: The 9-11 experience. Journal of the American Medical Association, 289, 2246-2253.

Kleinman, S., Kuhns, M., Todd, D., Glynn, S., McNamara, A., Demarco, A., and Busch, M.P. (2003). Frequency of HBV DNA detection in U.S. blood donors positive for anti-HBc: Implications for transfusion transmission and donor screening. Transfusion, 43, 696-704.

Schreiber, G.B., Sanchez, A.M., Glynn, S.A., and Wright, D.J. (2003). Increasing blood availability by changing donation patterns. Transfusion, 43, 591-597.

Wang, B., Schreiber, G.B., Glynn, S.A., Nass, C.C., Smith, J.W., Higgins, M.J., Hutching, S.T., Wright, D.J., McEntire, R., and Murphy, E.L. (2003). Prevalence of transfusion-transmissible viral infections in first-time U.S. blood donors by donation site. Transfusion, 43, 705-712.

Sanchez, A.M., Schreiber, G.B., Glynn, S.A., Bethel, J., Kessler, D., Chang, D., and Zuck, T.F. (2003). Blood donor perceptions of health history screening with a computer-assisted self-administered instrument. Transfusion, 43, 165-172.

Sharma, U.K., Stramer, S.L., Wright, D.J., Glynn, S.A., Hermansen, S., Schreiber, G.B., Kleinman, S.H., and Busch, M.P. (2003). Impact of changes in viral marker screening assays. Transfusion, 43, 202-214.

Glynn, S.A., Williams, A.E., Nass, C.C., Bethel, J., Kessler, D., Scott, E.P., Fridey, J., Kleinman, S.H., and Schreiber, G.B. (2003). Attitudes towards blood donation incentives in the United States: Implications for donor recruitment. Transfusion, 43, 7-16.

Schreiber, G.B., Glynn, S.A., Damesyn, M.A., Wright, D.J., Tu, Y., Dodd, R.Y., and Murphy, E.L. (2003). Lapsed donors: An untapped resource. Transfusion, 43, 17-24.

Glynn, S.A., Kleinman, Wright, D.J., and Busch, M.P. (2002 Editorial). International application of the incidence/window period model. Transfusion, 42, 966-972.

Schreiber, G.B., Glynn, S.A., Satten, G.S., Kong, F., Wright, D.J., Busch, M.P., Tu, Y., and Kleinman, S.H. (2002). HIV seroconverting donors delay their return: Screening test implications. Transfusion, 42, 414-421.

Glynn, S.A., Kleinman, S.H., Schreiber, G.B., and Zuck, T. (2002). Motivations to donate blood: Demographic comparisons. Transfusion, 42, 216-225.

Glynn, S.A., Smith, J.W., Schreiber, G.B., Kleinman, S.H., Nass, C.C., Bethel, J., Biswas, B., Thomson, R.A., and Williams, A.E., for the NHLBI REDS Study Group. (2001). Repeat whole blood and apheresis donors: Safety profile and response to incentive programs. Transfusion, 41, 736-743.

Liu, H., Leung, P., Glynn, S., and Murphy, E.L. (2001). Human T-lymphotropic virus type II (HTLV-II) RFLP subtypes A0 and B4/B5 are associated with different demographic and geographic characteristics in the United States. Virology, 279, 90-96.

Sanchez, A.M., Schreiber, G.B., Bethel, J., McCurdy, P.R., Glynn, S.A., Williams, A.E., and Gilcher, R., for the NHLBI REDS Study Group. (2001). Prevalence, donation practices and risk assessment of blood donors with hemochromatosis. Journal of the American Medical Association, 286,1475-1481.

Sharma, U.K., Schreiber, G.B., Glynn, S.A., Nass, C.C., Higgins, M.J., Tu, Y., Bethel, J., and Williams, A.E. (2001). Knowledge of HIV/AIDS transmission and screening in US blood donors. Transfusion, 41, 1341-1350.

Schreiber, G.B., Glynn, S.A., Busch, M.P., Sharma, U.K., Wright, D.J., and Kleinman, S.H., for the NHLBI REDS Study Group. (2001). Incidence rates of viral infections among repeat donors: Are frequent donors safer? Transfusion, 41,730-735.

Wu, Y., Glynn, S.A., Schreiber, G.B., Wright, D.J., Lo, A., Murphy, E.L., Kleinman, S.H., and Garraty, G. (2001). Time trends in demographics of U.S. first time blood donors. Transfusion, 41, 360-364.

Glynn, S.A., Kleinman, S.H., Schreiber, G.B., Busch, M., Wright, D., Smith, J., Nass, C.C., and Williams, A. (2000). Trends in incidence and prevalence of major transfusion-transmissible viral infections in United States blood donors, 1991 to 1996. Journal of the American Medical Association, 284, 229-235.

Glynn, S.A., Murphy, E.L., Wright, D., Sacher, R., Fridey, J., and Schreiber, G. (2000). Laboratory abnormalities in former blood donors seropositive for human T-lymphotropic virus types 1 and 2: A prospective analysis. Archives of Pathology and Laboratory Medicine, 124, 550-555.

Murphy, E.L., Bryzman, S., Glynn, S., Ameti, D., Thomson, R., Williams, A., Nass, C., Ownby, H., Schreiber, G., Kong, F., and Neal, K. (2000). Risk factors for hepatitis C virus (HCV) infection in U.S. blood donors. Hepatology, 31, 756-762.

Murphy, E., Glynn, S., Fridey, J., Smith, J., Sacher, R., Nass, C., Ownby, H., Wright, D., and Nemo, G. (1999). Increased incidence of infectious diseases and neurologic abnormalities during prospective followup of HTLV-II and -I infected donors. Archives of Internal Medicine, 159, 1485-1491.

Murphy, E., Glynn, S., Watanabe, K., Fridey, J., Smith, J., Sacher, R., Wright, D., Schreiber, G., and Luban, N. (1998). Laboratory test differences associated with HTLV-I and HTLV-II infection. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 17, 332-338.

Glynn, S., Schreiber, G., Busch, M., Kleinman, S., Williams, A., Nass, C., Ownby, H., and Smith, J. (1998). Demographic characteristics, unreported risk behaviors, and the prevalence and incidence of viral infections: A comparison of apheresis and whole-blood donors. Transfusion, 38, 350-358.

Kleinman, S., Busch, M., Hall, L., Thomson, R., Glynn, S., Gallahan, D., Ownby, H., and Williams, A. (1998). False-positive HIV-1 test results in a low-risk screening setting of voluntary blood donation. Journal of the American Medical Association, 280, 1080-1085.

Busch, M., Glynn, S., and Schreiber, G. (1997). Potential increased risk of virus transmission due to exclusion of older donors because of concern over Creutzfeldt-Jakob disease. Transfusion, 37, 996-1002.

Murphy, E., Glynn, S., Fridey, J., Sacher, R., Smith, J., Wright, D., Newman, B., Gibble, J., Hansma, D., Nass, C., Schreiber, G., and Nemo, G. (1997). Increased prevalence of infectious diseases and other adverse outcomes in human T lymphotropic virus types I- and II-infected blood donors. Journal of Infectious Diseases, 176, 1468-1475.

Glynn, S., Albanes, D., Pietinen, P., Brown, C., Rautalahti, M., Tangrea, J., Gunter, E., Barrett, M., Virtamo, J., and Taylor, P. (1996). Colorectal cancer and folate status: A nested case-control study among male smokers. Cancer Epidemiology, Biomarkers and Prevention, 5, 487-494.

Glynn, S,. Albanes, D., Pietinen, P., Brown, C., Rautalahti, M., Tangrea, J., Taylor, P., and Virtamo, J. (1996). Alcohol consumption and risk of colorectal cancer in a cohort of Finnish men. Cancer Causes and Control, 7(2), 214-223.

Glynn, S., and Albanes, D. (1994). Folate and cancer: A review of the literature. Nutrition and Cancer, 22(2), 101-119.

Brox, A., Glynn, S., and Sullivan, A.K. (1984). Blastic variants of rat promyelocytic leukemia produce neurologic disease. Leukemia Research, 8(1), 81.

Glynn, S., and Sullivan, A.K. (1983). In vitro lines of the BN rat promyelocytic leukemia that differ from the parent. Leukemia Research, 7, 557.