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NCTR Centers of Excellence
The Center for Hepatotoxicology develops and applies a systems toxicology
approach to the analysis of questions in liver toxicity based on an integrated cell,
molecular, transcriptomic, proteomic, and metabolomic platform. Biomarker profiles are
generated for more effective assessment of risk for acute toxicity and liver cancer
development. Biomarkers of liver injury and disease in mouse, rat, and human samples are
developed through an integrated omics analysis of biofluids and tissues from liver injury
and disease. The integration of signaling pathway for cell proliferation, apoptosis, and
differentiation provides the framework to assess these biomarkers. Development of new
methods for identification and limiting the effect of agents to cause liver toxicity is of
great importance in support of the FDA's Critical Path Initiative and the long-term impact
on public health.Contact Information
For more information please contact Dr. Donna L. Mendrick, at 870-543-7718 or donna.mendrick@fda.hhs.gov. |
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