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Patent Number:	US 6423551
Patent Title:	Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
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Issue Date:	01/01/2002
Inventor(s):	Weiss, Shimon (Pinole, CA); Bruchez, Jr., Marcel (Albany, CA); Alivisatos, Paul (Oakland, CA)
Lab/Technology Center:	University of California
Contract Number:	AC03-76SF00098
Subject Categories:	organo; luminescent; semiconductor; nanocrystal; probes; biological; applications; process; probes; semiconductor; nanocrystal; compound; described; capable; linking; affinity; molecule; compound; semiconductor; nanocrystal; capable; emitting; electromagnetic; radiation; andor; absorbing; energy; andor; scattering; diffracting; electromagnetic; radiation--when; excited; electromagnetic; radiation; source; particle; beam; linking; agent; portion; linked; semiconductor; nanocrystal; portion; capable; linking; affity; molecule; compound; linked; affinity; molecule; form; semiconductor; nanocrystal; probe; capable; bonding; detectable; substance; subsequent; exposure; excitation; energy; excite; semiconductor; nanocrystal; probe; causing; emission; electromagnetic; radiation; described; processes; semiconductor; nanocrystal; compound; semiconductor; nanocrystal; probe; probe; determine; presence; detectable; substance; material; electromagnetic radiation; electromagnetic radiation; electromagnetic radiation; electromagnetic radiation; particle beam; radiation source; semiconductor nanocrystal; semiconductor nanocrystal; semiconductor nanocrystal; semiconductor nanocrystal; semiconductor nanocrystal; semiconductor nanocrystal; semiconductor nanocrystal; semiconductor nanocrystal /436/424/428/
Assignee:	The Regents of the University of California (Oakland, CA)
Abstract:	A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation--when excited by an electromagnetic radiation source or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affity molecule. The compound is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. Subsequent exposure to excitation energy will excite the semiconductor nanocrystal in he probe, causing the emission of electromagnetic radiation. Further described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.
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