Bibliographic Citation
| US 5990479 | |
| Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes | |
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| 01/01/1999 | |
| Weiss, Shimon (Pinole, CA); Bruchez, Jr., Marcel (Albany, CA); Alivisatos, Paul (Oakland, CA) | |
| Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA | |
| AC03-76SF00098 | |
| organo; luminescent; semiconductor; nanocrystal; probes; biological; applications; process; probes; luminescent; semiconductor; nanocrystal; compound; described; capable; linking; affinity; molecule; compound; comprises; semiconductor; nanocrystal; capable; emitting; electromagnetic; radiation; luminescing; narrow; wavelength; band; absorbing; energy; scattering; diffracting; electromagnetic; radiation--when; excited; electromagnetic; radiation; source; narrow; broad; bandwidth; particle; beam; linking; agent; portion; linked; semiconductor; nanocrystal; portion; capable; linking; affinity; molecule; luminescent; semiconductor; nanocrystal; compound; linked; affinity; molecule; form; organo; luminescent; semiconductor; nanocrystal; probe; capable; bonding; detectable; substance; material; analyzed; capable; emitting; electromagnetic; radiation; narrow; wavelength; band; absorbing; scattering; diffracting; energy; excited; electromagnetic; radiation; source; narrow; broad; bandwidth; particle; beam; probe; stable; repeated; exposure; light; presence; oxygen; radicals; described; process; luminescent; semiconductor; nanocrystal; compound; organo; luminescent; semiconductor; nanocrystal; probe; comprising; luminescent; semiconductor; nanocrystal; compound; linked; affinity; molecule; capable; bonding; detectable; substance; process; described; probe; determine; presence; detectable; substance; material; luminescent semiconductor; luminescent semiconductor; luminescent semiconductor; luminescent semiconductor; luminescent semiconductor; luminescent semiconductor; luminescent semiconductor; particle beam; particle beam; electromagnetic radiation; electromagnetic radiation; electromagnetic radiation; electromagnetic radiation; electromagnetic radiation; radiation source; radiation source; broad band; broad band; broad bandwidth; broad bandwidth; wavelength band; wavelength band; semiconductor nanocrystal; semiconductor nanocrystal; semiconductor nanocrystal; semiconductor nanocrystal; semiconductor nanocrystal; semiconductor nanocrystal; semiconductor nanocrystal; semiconductor nanocrystal; semiconductor nanocrystal; narrow wavelength; narrow wavelength; portion capable; probe capable; linking agent /250/252/356/378/422/436/ | |
| Regents of University of California (Oakland, CA) | |
| A luminescent semiconductor nanocrystal compound is described which is capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation (luminescing) in a narrow wavelength band and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation--when excited by an electromagnetic radiation source (of narrow or broad bandwidth) or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The luminescent semiconductor nanocrystal compound is linked to an affinity molecule to form an organo luminescent semiconductor nanocrystal probe capable of bonding with a detectable substance in a material being analyzed, and capable of emitting electromagnetic radiation in a narrow wavelength band and/or absorbing, scattering, or diffracting energy when excited by an electromagnetic radiation source (of narrow or broad bandwidth) or a particle beam. The probe is stable to repeated exposure to light in the presence of oxygen and/or other radicals. Further described is a process for making the luminescent semiconductor nanocrystal compound and for making the organo luminescent semiconductor nanocrystal probe comprising the luminescent semiconductor nanocrystal compound linked to an affinity molecule capable of bonding to a detectable substance. A process is also described for using the probe to determine the presence of a detectable substance in a material. | |
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